targeted treatments
Targeted treatments for fragile X syndrome
... of treatments aimed at these targets has been tested in cell culture and in animal models of FMRP deficiency, including both the dfmr mutant fly and Fmr1 knockout mouse ...2003). Targeted treatments ...
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Fragile X and autism: Intertwined at the molecular level leading to targeted treatments
... Fragile X syndrome (FXS) is caused by an expanded CGG repeat (> 200 repeats) in the 5’ untranslated portion of the fragile mental retardation 1 gene (FMR1), leading to deficiency or absence of the FMR1 protein (FMRP). ...
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A simplified interventional mapping system (SIMS) for the selection of combinations of targeted treatments in non-small cell lung cancer
... novel targeted therapies for subsets of patients with NSCLC and EGFR mutations, as well as ALK or ROS translocations, and now a variety of other small subsets (BRAF mutations, HER2 mutations, ...(iii) ...
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A study of PD-L1 expression in KRAS mutant non-small cell lung cancer cell lines exposed to relevant targeted treatments.
... to targeted treatments such as EGFR and ALK inhibitors in defined subsets of patients [2] [3] [4] [5] and, most recently, immune checkpoint modulating drugs [6] ...
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Targeted treatments for cervical cancer: a review
... Research advances in the understanding of the molecular biology of HPV-related tumors have identified molecular targets for therapy such as antigen tumors, growth factor receptors, signaling transduction pathways, and ...
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Two breakthrough gene targeted treatments for spinal muscular atrophy: challenges remain
... Issues related to cell types targeted. The principal clinical man- ifestations of SMA likely result from diminished SMN protein within motor neurons themselves. Notably, however, experimen- tal evidence indicates ...
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New targeted treatments for non-small-cell lung cancer – role of nivolumab
... with nivolumab (NIVO; anti-programmed death-1 [PD-1]) in advanced non-small cell lung cancer (NSCLC): safety, efficacy and correlation of outcomes with PD-1 ligand (PD-L1) expression. [r] ...
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Clinical utility of targeted treatments in the management of epithelial ovarian cancer
... involved two different dosing schedules for olaparib (cohort 1, 400 mg twice daily; cohort 2, 100 mg twice daily), with objec- tive tumor response by RECIST criteria being the primary endpoint of the study. A 33% and 13% ...
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Targeted treatments in advanced renal cell carcinoma: focus on axitinib
... of targeted therapies for the treatment of advanced metastatic RCC has changed the progression- free survival and overall survival of these ...seven targeted therapies (sorafenib, sunitinib, bevacizumab/ ...
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Phosphodiesterase 4-targeted treatments for autoimmune diseases
... Indeed, selective PDE4 inhibitors have generated substantial interest as a treatment for several autoimmune conditions including ankylosing spondylitis, Alzheimer’s disease, psoriasis, p[r] ...
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Targeted treatments for multiple myeloma: specific role of carfilzomib
... A Phase II study by Bringhen et al evaluated the efficacy and safety of the combination of carfilzomib, cyclophosphamide, and dexamethasone in elderly patients ( $ 65 years of age) or[r] ...
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Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma
... retinoblastoma gene (RB1). RB1 was the first identified tumor suppressor gene and has defined roles in the regulation of cell cycle progression, DNA replication, and terminal differentiation. However, despite the ...
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Looking forward to new targeted treatments for chronic spontaneous urticaria
... The introduction of omalizumab to the management of chronic spontaneous urticaria (CSU) has markedly improved the therapeutic possibilities for both, patients and physicians dealing with this disabling disease. But there ...
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Suffocating cancer: hypoxia-associated epimutations as targets for cancer therapy
... Combination of HDAC inhibitors with other targeted treatments can have an additive effect Verheul et al ., demonstrated in prostate and renal cancer cell lines that combination treatment[r] ...
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Targeted Therapy in the Management of Elderly Patients with Pancreatic Metastases from Renal Cell Carcinoma
... Conclusion Our results in this rare group of patients demonstrate that targeted treatments can be used safely in elderly patients who are usually unfit for surgery or their disease is un[r] ...
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Socio economic impacts of alternative GIN control practices Project deliverable 11 (WP4)
... Changes in the pasture system 2 Genetic selection for 0.33 parasites control 3 Targeted treatments 0 Considered as the current “standard”, TT and targeted however two farmers ranked it i[r] ...
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Human Papillomavirus Genotype Specificity of Hybrid Capture 2 Low Risk Probe Cocktail
... Finally, in 23 (8.0%) of 285 samples recognized as HPV positive using the hc2 low-risk probe cocktail, no HPV DNA was detected using all seven genotyping methods (Table 1). Focusing on five hc2-targeted HPV ...
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Development of In-Vitro and In-Vivo Devices to Study the Mechanobiology of Ligament Healing
... In order to test the repeatability of the device in a research setting, a pilot study was conducted utilizing three Sprague-Dawley rats (age = 6 months). The device was used to perform IASTM to medial collateral ...
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The Impact of Infertility on Daily Occupations and Roles
... While some engaged in leisure and hobbies as a form of emotional self-care, many participants felt that their hobby and leisure activities were nega- tively impacted. Participant 7 reported that, "it pretty much ...
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