Targeting apoptotic cell death
The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes
... BH3-only death activator family and a key determinant of cell fate upon cytokine ...BCR-ABL1-expressing cell apoptosis in response to imatinib (IM) ...large cell lymphoma (ALCL) cell ...
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Neonatal Hypoxic-Ischemic Brain Injury: Apoptotic and Non-Apoptotic Cell Death
... proteins are required for initiation, vesicle elongation, autophagosome maturation, lysosome fusion, and degradation. Targeting the autophagic machinery could have significant impact in protecting the neonatal ...
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Mitochondria targeting and its consequences for cell death in neuroblastoma
... 498-506 Targeting energy-producing pathways is a promising approach for cell death stimulation and cancer cell ...specific targeting of cancer cells’ glutaminase or withdrawal of ...
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The potential utility of acetyltanshinone IIA in the treatment of HER2-overexpressed breast cancer: Induction of cancer cell death by targeting apoptotic and metabolic signaling pathways
... cancer cell growth by inducing cell cycle arrest and apoptosis To determine the cause and the nature of cell death by which ATA mediated its cytotoxic effects on HER2- positive breast cancer ...
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Pharmacological Targeting of Cell Cycle, Apoptotic and Cell Adhesion Signaling Pathways Implicated in Chemoresistance of Cancer Cells
... factors. Death receptors DR4 and DR5 in cancer cells have high-affinity binding of TRAIL and their receptor/ligand interactions induce extrinsic apoptotic cell-signaling pathway [ 118 ...
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Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis
... prevents apoptotic cell death, restores host immunity and decreases mortality in clinically-relevant models of bacterial and fungal sepsis ...T cell exhaustion is postulated to occur after ...
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Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death
... small cell lung cancer and lung adenocar- cinoma ...proliferation, cell cycle and cell death gene sets as well as with subcellular organelles in gene ontology ...cell death. Our ...
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The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line
... not cell-cycle specific, appeared to be through induction of early apoptosis via blockade of Eag channels while ergtoxin showed no effect on apop- tosis but exhibited its antiproliferative actions by blocking ...
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Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1
... while targeting MTH1 in normal cells had no impact on survival, 32,33 and MTH1 knockout mice were largely ...suppressed cell proliferation specifically in cancer but not in noncancer ...therapies ...
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A Novel Poly Herbal Formulation Induces Apoptotic Cell Death in Prostate and Colorectal Carcinoma Cells
... therapies targeting multiple cellular pathways, properly formulated herbal cocktails have the advantages of synergism and improved therapeutic efficacy compared with individual herbs with no or less side effects ...
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Cytoskeletal Changes in Non-Apoptotic Cell Death
... of apoptotic cell death where formation of dynamic membrane protrusions is mediated by the specific cleavage and contraction of actomyosin complex in the presence of caspase-activated Rho kinases ...
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Flipping the dogma – phosphatidylserine in non-apoptotic cell death
... between a dying cell and the immune system. How dying cells affect signaling in phagocytes will be fascinating to examine in light of this new understanding. In this regard, studying the contents, uptake, and ...
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Targeting immunogenic cell death in cancer
... domain death agonist; c-FLIP, cellular FLICE-like inhibitory protein; cGAMP, cyclic guanosine monophosphate –adenosine monophosphate; cGAS, cyclic GMP-AMP synthase; CRT, calreticulin; CXCL10, chemokine C-X-C motif ...
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Evaluating the discriminating capacity of cell death (apoptotic) biomarkers in sepsis
... these apoptotic biomarkers with both PCT and the APACHE II, and the known biology of apoptosis, we conjecture that apop- totic biomarkers reflect an important septic pathway non-collinear or not otherwise ...
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Involvement of Pro-Apoptotic and Pro-Autophagic Proteins in Granulosa Cell Death
... the apoptotic bodies observed at ultrastructural ...granulosa cell death ...of cell death during the follicular atresia in the rat ...
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Interleukin 10 inhibits apoptotic cell death in infectious mononucleosis T cells
... T lymphocytes from patients with acute EBV-induced infectious mononucleosis rapidly die by apoptosis in vitro. Because human and viral IL-10 are likely to be induced during acute EBV infection and display a variety of ...
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TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death
... www.impactjournals.com/oncotarget using a modified ATOMS approach, we overexpressed HSP90 peptides and found that these “neo-proteins” do not display pro-apoptotic capacity. Point mutations of the most probable ...
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The calcimimetic R-568 induces apoptotic cell death in prostate cancer cells
... induce apoptotic cell death in parathyroid cells in addition to reducing PTH secretion ...cancer cell lines, androgen receptor- positive LNCaP cells and androgen receptor-negative PC- 3 ...
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Selective apoptotic cell death effects of oral cancer cells treated with destruxin B
... cancer cell lines, GNM (Neck metastasis of gingival carcinoma) and TSCCa (Tongue squamous cell carcinoma) cells, and normal gingival fibroblasts (GF) were also included as ...
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Mycobacterium tuberculosis infection induces non apoptotic cell death of human dendritic cells
... reported constraint of Mtb replication within DCs with- out the addition of IFN-g. The proposed difference in findings was suggested to be due to removal of the cyto- kines GM-CSF and IL-4 from DCs upon infection with ...
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