Targeting the interaction between B cell and T cell
Pre clinical assessment of chimeric antigen receptor t cell therapy targeting CD19+ B cell malignancy
... human cell lines, Raji and Hela, used as positive references resulted in significant tumor growth and consequent death of ...autologous T cells expressing an enhanced affinity T-cell receptor ...
11
The impact of malaria parasites on dendritic cell–T cell interaction
... dendritic cell (DCs) function affecting the generation of helper T cell ...These T cells fail to help B cell responses, reducing the production of antibodies that are necessary ...
16
Cell cell interactions in synovitis: Interactions between T cells and B cells in rheumatoid arthritis
... Differences between patients in forming follicles with germinal centers, T-cell–B-cell aggregates without germinal center reactions, or loosely organized ...
7
Novel Insights into Membrane Targeting of B Cell Lymphoma
... strategies targeting the BCR co-receptor CD19 are encouraging for patients with relapsed/refractory ...by T cells (CD19-CAR T cells) consist of an extracellular domain specific for CD19 on ...
31
Targeting IRAK1 in T-Cell acute lymphoblastic leukemia
... large B cell lymphoma (DLBCL) [17, ...in T-ALL by Taqman low density array (TLDA) ...of T-ALL so we sought to further explore the potential role of IRAK1 as a therapeutic target in ...
10
Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity
... the B- and T-cells arms of the adoptive immune ...circulating B-cells and followed with RIT treatment [19]. They found that B-cell depletion with Rituximab was not sufficient to prevent ...
11
Surface receptor Toso controls B cell–mediated regulation of T cell immunity
... the targeting vector was designed to have exons 4–7 flanked by loxP ...stem cell clones were identified by Southern blotting and were injected into ...
18
Cross reactive human B cell and T cell epitopes between influenza A and B viruses
... and B viruses form different genera, which were originally distinguished by antigenic differences in their nucleoproteins and matrix 1 ...Cross-protection between these two genera has not been observed in ...
10
Targeting Hepatitis B Virus-Infected Cells with a T-Cell Receptor-Like Antibody
... CD8 T cells are activated when their T-cell receptors (TCRs) recognize the specific viral peptide/major histocompatibility complex (MHC) class I (pMHC) complexes present on the surface of infected ...
8
Cell to Cell Interaction
... about cell–cell recognition and adhesion were carried out by removing a developing organ from a chick or amphibian embryo, dissociating the organ’s tissues to form a suspension of single cells, and ...
6
Cell cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis
... of T cells, and much of the resulting tissue destruction is a consequence of the resulting pro-inflammatory cytokine ...reduce T cell activation by the blocking of upstream events, particularly the ...
5
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
... enhance T-cell immunogenicity have been used to improve peptide-based vaccination for a range of ...prime T-cell responses of greater magnitude, the efficacy of constituent ...
21
Targeting the Bcl-2 Family in B Cell Lymphoma.
... of B cell lymphoma, as well as other hematologic malignancies and solid-organ cancers, there remains a significant lack of knowledge of these proteins and their requirements in non- Hodgkin ...other ...
22
Relationship between systemic lupus erythematosus T cell subsets, anti T cell antibodies, and T cell functions
... differing T cell T4+/T8+ ratios and that the ratio correlated with clinical features of the ...blood T cell subsets in these patients were related to the specificity of anti-T ...
13
Unbiased identification of T cell receptors targeting immunodominant peptide-MHC complexes for T cell receptor immunotherapy
... specific T cells, PBMC samples frozen after one stimulation cycle were thawed and re-stimulated for 14 days to be used in a co-culture assay only with E5-specific T cells (K562-B*15:01) or ...
11
On the steps of cell to cell HIV transmission between CD4 T cells
... or cell lines as target cells which behave differently in their ability to capture HIV particles and to become productively infected after engaging the ...of cell-to-cell HIV transmission in the ...
6
T cell and B cell responses in a rat model of rheumatic heart disease
... Studies have implicated mimicry between the GAS M protein, an alpha helical coiled-coil extending from the surface of the bacterium and host tissue proteins such as cardiac myosin. However, despite decades of ...
20
T cell and B cell responses in a rat model of rheumatic heart disease
... in all rats, including vehicle control rats immunised with PBS/FCA. Swelling gradually decreased in the foot over 7-14 days but returned between days 14 and 21 p.i. (Figure 7.2). On several occasions, animals ...
243
Targeting CD19 in B-cell lymphoma: emerging role of SAR3419
... Abstract: Non-Hodgkin lymphoma symbolizes a heterogeneous group of diseases resulting from malignant transformation of lymphocytes with differing patterns of behavior and responses to treatment. The potential curability ...
9
Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma
... The BCR signal is initially transmitted by LYN kinase leading to activation of various signaling pathways including JNK. We therefore evaluated the activation status of LYN in MCL cells and its involvement in cell ...
14