targeting signal
Secretory protein traffic Chromogranin A contains a dominant targeting signal for the regulated pathway
... secretagogue-stimulated release. These data demonstrate that human CgA expressed in PC-12 cells is targeted to regulated secretory vesicles. In addition, human CgA can divert an ordinarily non-secreted protein into the ...
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Hepatitis B Virus Polymerase Localizes to the Mitochondria, and Its Terminal Protein Domain Contains the Mitochondrial Targeting Signal
... To understand subcellular sites of hepatitis B virus (HBV) replication, we visualized core (Cp), polymerase (Pol), and pre- genomic RNA (pgRNA) in infected cells. Interestingly, we found that the majority of Pol ...
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Trypanosome Alternative Oxidase Possesses both an N-Terminal and Internal Mitochondrial Targeting Signal
... mitochondrial targeting signals (MTS) by receptor translocases of outer and inner membranes of mitochondria is one of the prerequisites for import of nucleus-encoded proteins into this ...the targeting ...
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Virion Incorporation of Human Immunodeficiency Virus Type 1 Nef Is Mediated by a Bipartite Membrane-Targeting Signal: Analysis of Its Role in Enhancement of Viral Infectivity
... membrane targeting of Nef and reduced its stability in infected ...membrane-targeting signal of the Src protein was fused to the N terminus of truncated Nef proteins, indicating that heterologous ...
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Identification of a Type 1 Peroxisomal Targeting Signal in a Viral Protein and Demonstration of Its Targeting to the Organelle
... peroxisomal targeting signal (PTS1) which essentially constitutes a tripeptide from the consensus sequence ...PTS1 signal, GFP-VP4 ⌬ CRL, resulted in diffuse cytoplasmic staining, suggesting a ...
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Characterization of nuclear targeting signal of hepatitis delta antigen: nuclear transport as a protein complex.
... We have previously noted that HDAg contains two leucine zipper motifs, one of which resides in the N-terminal portion amino acid residues 30 to 51, LERDLRKLKKKIKKLEEDNPWL, although the l[r] ...
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Advances in Targeting Signal Transduction Pathways.
... mTOR is present in two complexes, mTORC1 and mTORC2. Both of these complexes play critical roles in signal transduction pathways and regulate cell growth and many other physiological processes. Rapamycin and ...
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Targeting signal transduction pathways of cancer stem cells for therapeutic opportunities of metastasis
... and targeting gene(s) responsible for intravasation to extravasation, dissemination and ultimate colonization of CSC & tumor cells at distant sites remains to be experimentally exploited and ...
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Distinct Roles for Peroxisomal Targeting Signal Receptors Pex5 and Pex7 in Drosophila
... P EROXISOMES are involved in a variety of important bio- chemical functions, notably lipid metabolism and the de- toxification of reactive species (De Duve and Baudhuin 1966; Bowers 1998; Wanders and Waterham 2006; Nguyen ...
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Habib, Shukry James (2006): Biogenesis and function of mitochondrial outer membrane proteins. Dissertation, LMU München: Fakultät für Biologie
... N-terminal targeting signal which has characteristics very similar to those of the cleaved signals (Hammen et ...presequence-like targeting signal at its carboxyl ...
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The golgin coiled-coil proteins capture different types of transport carriers via distinct N-terminal motifs
... mitochondrial targeting signal, the mitochondrial GMAP-210 captures vesicles containing Golgi resident membrane proteins, and also shows tran- sient capture of ER to Golgi carriers ...
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The intracytoplasmic domain of gp41 mediates polarized budding of human immunodeficiency virus type 1 in MDCK cells.
... Together, these data are consistent with a model of polarized virus budding in which capsid proteins, lacking a targeting signal, are targeted for specific basolateral release via an int[r] ...
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Nuclear targeting of the tegument protein pp65 (UL83) of human cytomegalovirus: an unusual bipartite nuclear localization signal functions with other portions of the protein to mediate its efficient nuclear transport.
... additional targeting sequences. The major NLS of pp65 is an unusual signal sequence composed of two weak NLS which function together as one strong bipartite nuclear targeting ...
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Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer
... antibody targeting CD90, β3 integrin, and ...of signal axis of CD90 and CD133 and therapeutic opportunities is illustrated in Figure ...therapy targeting signal axis of CD90 and CD133 may be ...
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Plasma membrane targeting of chimeric intracisternal A-type particle polyproteins leads to particle release and specific activation of the viral proteinase.
... poly(A) signal (kindly provided by ...membrane-targeting signal of the Src protein, a fragment containing the entire gag-PR region of the IAP genome was amplified by PCR (forward primer, ...
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Identification of a Cytoplasmic Targeting/Retention Signal in a Retroviral Gag Polyprotein
... membrane- targeting signal (14, 28, 38, 41, ...this signal appears to still be functional even with an amino acid insertion after the basic patch of mutant ...specific signal-directed ...
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Stan, Tincuta (2003): The Translocase of the Outer Membrane of Mitochondria (TOM complex): Recognition of Mitochondrial Targeting Signals. Dissertation, LMU München: Fakultät für Biologie
... Fig. 9. Interaction of the targeting signal of BCS1 with the TOM complex (A) BCS1(1-126)-DHFR and pSu9(1-69)-DHFR were incubated with N. crassa OMV for 20 min at 0°C in the presence of MTX/NADPH. OMV were ...
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Protein Import into Hydrogenosomes of Trichomonas vaginalis Involves both N-Terminal and Internal Targeting Signals: a Case Study of Thioredoxin Reductases
... examine targeting and the role of presequences in greater ...for targeting and that internal targeting se- quences are present in the case of SCS ␣ and in ...internal targeting signals are ...
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Tyrosine Residues in the Cytoplasmic Domains Affect Sorting and Fusion Activity of the Nipah Virus Glycoproteins in Polarized Epithelial Cells
... a signal shown to act as a targeting signal in other proteins with basolateral expression (1, 20, 22, ...dileucine signal, a dityrosine motif is responsible for basolateral G ...basolateral ...
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vicK Gene as Potential Identification Marker for Staphylococcus aureus
... DOI: 10.4236/jbm.2018.611010 105 Journal of Biosciences and Medicines rapid identification of the bacteria. vicK is a unique gene that encodes the two-component signal transduction system, responsible for ...
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