Targeting T cells for therapy
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis
... of T reg cell proliferation. Lymph node cells and erythrocyte-depleted spleen cells of five normal Lewis rats were pooled and passed over nylon wool ... T cells were purified from the ...
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Oncolytic viral therapy: targeting cancer stem cells
... bispecific targeting of two separate tumor-associated antigens can be achieved with one infectious viral unit and ...therefore, targeting additional markers, especially receptors involved in CSC niche ...
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Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV 1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells
... infected cells by cytotoxic T lymphocytes ...ⴙ T cells from chronic HIV-1-infected par- ticipants on long-term cART can be primed by dendritic cells ...ⴙ T cell responders ...
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Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy
... TKI therapy are underway ...biguanide therapy. For example, LKB1 deficient cells show increased sensitivity to metabolic stress and were predictive of susceptibility to phenformin therapy, ...
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Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8+ T cells in the tumor microenvironment
... conventional therapy [38–40]. The combination of trastuzumab, an antibody targeting human epidermal growth factor re- ceptor type 2 (HER2), and chemotherapy has reportedly increased survival in patients ...
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Targeting Histone Deacetylases in Melanoma and T-cells to Improve Cancer Immunotherapy
... only cells that yield from the tumor ...of cells are insufficient for ACT ...feeder cells and activation via CD3 complex of the TCR by antibody use ...
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Targeting Toll like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus
... Taken together these data suggest that circulating DNA in lupus sera is either enriched in immunostimulatory CpG sequences, or is epigenetically modified to ensure more avid interaction between the DNA and TLR9. Indeed, ...
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Targeting VEGFR1- and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy
... tumor cells and tumor microenvironment. Bone marrow derived cells (BMDCs) constitute important components of the tumor ...non-tumor cells, including BMDCs, in esophageal cancer (EC) progression and ...
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Overcoming Innate and Acquired Therapy Resistance by Targeting DNA Repair in Human Cancer Cells
... of cells harboring inactivating BRCA2 ...in cells treated with BRCA2 ASO and ...affected cells to generate additional energy necessary to deal with the results of this ...
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Tracing and targeting cancer stem cells: New venture for personalized molecular cancer therapy.
... tumor therapy should be relatively ...targeted therapy can be demonstrated is in the area of combination therapy (Figure ...cytotoxic therapy and reduce recurrence risk [76,77] ...stem ...
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Targeting Mnks for Cancer Therapy
... cancer therapy represents the remarkable progress of the decades’ research into mechanisms of cancer ...cancer cells to survive or adapt to the selective pressure imposed by the therapy and ...
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Targeting mTOR for cancer therapy
... Principle mechanisms of mTOR inhibitor resistance in cancer Drug resistance is a serious problem in treating cancer. Although there may be an initial response, long-lasting treatment with chemotherapeutic or ...
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Endogenous T cells prevent tumor immune escape following adoptive T cell therapy
... that targeting tumors with a T cell population specific for a restricted set of antigens may lead to the selective outgrowth of antigen-negative tumor vari- ...endogenous T cells during ACT, ...
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CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia
... CAR-T therapy has achieved great success in a variety of malignant diseases, particularly for hematological cancer in which lineage markers of restricted expression are used as target ...CAR-T ...
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Chimeric antigen receptor T cells: a novel therapy for solid tumors
... CAR-T cells recognized and killed HER2+ breast and ovarian cancer cells in ...CAR-T cells also significantly restricted tumor growth ...potent targeting ability of oligoclonal ...
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Targeting cytokine and therapy induced PIM1 activation in T-cell acute lymphoblastic leukemia and lymphoma
... of T-ALL and T-LBL 2-7 . PIM1 activation in primary T-ALL/T- LBLs can occur through T-cell receptor driven translocations 5,6 or activating mutations targeting IL7RA, JAK1, JAK3 ...
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Targeting hypoxic cancer stem cells (CSCs) with Doxycycline : implications for optimizing anti angiogenic therapy
... cancer cells, with metabolic links to fatty acid oxidation ...anti-angiogenic therapy often induces tumor hypoxia, allowing CSCs to survive and propagate, ultimately driving tumor ...
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Targeting hypoxic cancer stem cells (CSCs) with Doxycycline : implications for optimizing anti-angiogenic therapy
... cancer cells, with metabolic links to fatty acid oxidation ...anti-angiogenic therapy often induces tumor hypoxia, allowing CSCs to survive and propagate, ultimately driving tumor ...
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Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model
... gene-engineered T cells has been challenging ...TCR T cell ...human cells or HPV-induced cancers, which makes its expression by healthy tissues highly ...TCR T cells is ...
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Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy
... þ T-cell response following Mtb infection, and improve bacterial ...as therapy for use in Mtb-infected individuals in TB- endemic areas; however, is logistically difficult to translate for human use as ...
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