Targeting the nuclear genome
Genome-Wide Screen for Inner Nuclear Membrane Protein Targeting in Saccharomyces cerevisiae
... Appropriate nuclear membrane structure is important for all eukaryotic organisms as evidenced by the numerous human diseases and alterations in gene expression caused by inappropriate targeting of proteins ...
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A nuclear targeting system in Plasmodium falciparum
... 2. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, ...
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Expression of a transferred nuclear gene in a mitochondrial genome
... mitochondrial targeting sequences and cis-regulatory ...a nuclear gene that has undergone intracellular transfer to the mitochondrial genome and become ...mitochondrial genome of several ...
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Dynamic nuclear reorganization during genome remodeling of Tetrahymena
... Tetrahymena nuclear differentiation is a highly regulated ...this genome remodeling occur before the developing macronuclei are even formed ...the targeting small RNAs occurs in meiosis — see ...
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Microtubule Network Facilitates Nuclear Targeting of Human Cytomegalovirus Capsid
... Human cytomegalovirus (HCMV) is a prevalent pathogen responsible for significant morbidity and mortality in immuno- suppressed individuals. It is a member of the betaherpesvirus family containing a double-stranded ...
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Targeting mitotic chromosomes : a conserved mechanism to ensure viral genome persistence
... virus; genome; mitosis 1. INTRODUCTION While the specific mechanism of genome segregation during mitotic cellular division employed by each DNA virus studied has subtle or sometimes major distinctions, the ...
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Microtubule-Independent Motility and Nuclear Targeting of Adenoviruses with Fluorescently Labeled Genomes
... The goal of our experiments was to examine the mechanisms of adenovirus nuclear targeting using a different experimental approach. We sought to follow the ultimate adenovirus ge- nome deposition into the ...
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Differential Targeting of Nuclear Pore Complex Proteins in Poliovirus-Infected Cells
... viral genome amplification and high levels of viral protein synthesis were not required for this process to ...viral genome, and consequently only input genomes are translated, and low levels of viral ...
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Targeting Promyelocytic Leukemia Protein: A Means to Regulating PML Nuclear Bodies
... Since various cell stimuli can induce interferon sig- naling or control p53 activity, it is likely that PML levels are controlled transcriptionally in a wide range of cellular conditions. Together, these data indicate ...
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Carboxy Terminus of Human Herpesvirus 8 Latency-Associated Nuclear Antigen Mediates Dimerization, Transcriptional Repression, and Targeting to Nuclear Bodies
... By analogy to EBNA-1, we suspect that LANA performs multiple functions required for latent infection. The list may include regulation of viral gene expression, replication of the viral genome, tethering to the ...
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Role of nuclear pore complex in simian virus 40 nuclear targeting.
... The nuclear accumulation of virion protein components and large T antigen in nonpermissive NIH 3T3 cells was similar to that in the permissive host, indicating that the ability to use NP[r] ...
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γ-Secretase Dependent Nuclear Targeting of Dystroglycan
... Dystroglycan is frequently lost in adenocarcinoma. a-dystroglycan is known to become hypoglycosylated due to transcriptional silencing of LARGE, whereas b-dystroglycan is proteolytically cleaved and degraded. The ...
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In vitro model for the nuclear transport of the hepadnavirus genome.
... DNA genome, but they replicate via an RNA intermediate, synthesized by the cellular RNA polymerase II in the nucleus of the infected ...Thus, nuclear transport of the viral DNA is required in the viral life ...
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Mitochondrial DNA segments in Catlle nuclear genome
... CATTLE NUCLEAR GENOME In many animal species (and humans), hundreds of sequences, which originated from the insertion of mtDNA into the nuclear genome, have been ...
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Molecular Map of the Chlamydomonas reinhardtii Nuclear Genome
... the nuclear genome is completed and annotated, it should be possible to accelerate positional clon- ing and transformation using a candidate gene ...
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Characterization of nuclear targeting signal of hepatitis delta antigen: nuclear transport as a protein complex.
... Function of two discrete region is required for nuclear localization of polymerase basic protein 1 of AIWSN/33 influenza virus (Hi N1). Transport of hepatitis B virus precore protein int[r] ...
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Nuclear Targeting of the Cauliflower Mosaic Virus Coat Protein
... National Research Council of Canada, Ottawa, Ontario, Canada K1A 0R6 2 Received 7 May 1998/Accepted 25 September 1998 The entry of the viral genomic DNA of cauliflower mosaic virus into the nucleus is a critical step of ...
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An Analysis of U.S. Policies Targeting the Iranian Nuclear Program
... 83 Iran to “provide all the details of her nuclear program” which was widely believed to have stemmed from pressure from the Bush administration. 225 While the Bush administration was leaving the task of ...
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Patterns of Intraspecific DNA Variation in the Daphnia Nuclear Genome
... complete genome sequence and a wide variety of new genomic resources, the Daphnia system is quickly becoming a promising new avenue for expanding our knowledge of nucleotide variation in natural ...
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Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma
... reference genome sequence. Alterna- tively, de novo genome assembly is computationally in- tensive, and any low-stringency mapping algorithm that would accurately identify insertion sites would also re- ...
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