Targets and mechanisms
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6
... probable targets of a small ...Interaction Targets, that integrates more than 20,000,000 data points from drug efficacies, post-treatment transcriptional responses, drug structures, reported adverse ...
24
Probing Cancer Targets and Therapeutic Mechanisms using Small Molecules
... new mechanisms of action and more disease- relevant ...the targets could be any protein or biologic and the small molecules could use different actions such as agonist/antagonist, protein-protein ...
175
Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain
... the mechanisms underlying chronic pain has emerged over the last three ...emerging targets in the central glial cell which show promise for the development of novel pain ...
15
Unlocking new molecular mechanisms and potential therapeutic targets for chronic lymphocytic leukemia
... molecular mechanisms resulting in disease development are still not clearly understood; therefore, the identification of factors that could predict the clinical course of CLL represents a crucial objective to ...
70
Identifying Mechanisms Of Resistance And Potential Therapeutic Targets For Pediatric Acute Myeloid Leukemia
... especially useful in this patient group are of interest. Since the completion of the work presented in Chapter 2, novel HDAC inhibitors have been developed clinically, such as panobinostat and vorinostat (reviewed ...
168
Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue specific outputs of Hedgehog signaling
... of targets in the on and off states, ...Possible mechanisms include differential affinity, input from linked cis-regulatory elements or participation of co-factors (Müller and Basler, ...the ...
12
Integrated miRNA and mRNA expression profiling identifies novel targets and pathological mechanisms in autoimmune thyroid diseases
... novel targets and pathological mechanisms in autoimmune thyroid diseases Rebeca Martínez-Hernandez a , Ana Serrano-Somavilla a , Ana Ramos-Leví a , Miguel Sampedro-Nu~nez a , Alberto Lens-Pardo a , Jose ...
14
The Kaposi's Sarcoma-Associated Herpesvirus K5 E3 Ubiquitin Ligase Modulates Targets by Multiple Molecular Mechanisms
... the mechanisms used by K3, alternative molecular pathways are utilized by this E3 ligase in the down regulation of intercellular adhesion molecule 1 (ICAM-1) and ...its targets occurs through multiple ...
11
Review Article Crosstalk between Oxidative Stress and Ferroptosis/Oxytosis in Ischemic Stroke: Possible Targets and Molecular Mechanisms
... Academic Editor: Wei Zhao Copyright © 2021 Jia-Xin Ren et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in ...
13
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7
... A classical drug development workflow usually starts by screening the activity of multiple ligands against the selected target. Once a hit is identified, its chemical structure is used as a starting point for chemical ...
22
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-3
... A hydrogen peroxide sensitive prodrug strategy for the targeted delivery of methotrexate is a novel, promising, approach for the treatment of patients with rheumatoid arthritis.. A Novel[r] ...
10
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–4
... 19. Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study Highlighted by M. Helena Vasconcelos Targeting cancer stem ...
13
Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments
... Recently, investigators have developed hybrid cells, called “cybrid”, to check the role of mitochondria in de- velopment of PD [148]. They have placed mitochondrial DNA from PD patients into neuroblastoma cells and found ...
35
Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature
... version mechanisms predominate in the lung vasculature but not in liver, where intravascular macrophages, known as Kupffer cells, are capable of eradicating many of the ...
14
Mindfulness Training Targets Neurocognitive Mechanisms of Addiction at the Attention-Appraisal-Emotion Interface
... psychophysiological mechanisms, including dysregulated interactions between bottom-up and top-down neural processes, that compel the user to seek out and use ...pathogenic mechanisms of the risk chain ...
25
Human metapneumovirus: Mechanisms and molecular targets used by the virus to avoid the immune system
... virus, mechanisms used by hMPV to avoid the host immune system are still ...these mechanisms, is the promotion of an anergic state in T cells, instead of an effective polarization or activation, which could ...
11
The Cytokine Balance During Canine Sepsis: Defining the Mechanisms of Amplification and Potential Targets for Intervention.
... α, it is not surprising that these anti-TNF-α molecules failed to provide protection for septic patients in clinical trials. Similar results were obtained in clinical trials designed to neutralize IL-1β. These early ...
167
Knowledge Management approaches to model pathophysiological mechanisms and discover drug targets in Multiple Sclerosis
... 138 6 Conclusion and Outlook: ******** ****** ****** ****** ****** ****** ****** ****** ****** ****** ***** Drug discovery with the help of Systems biology is a modern approach, as the conventional means of drug ...
160
Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy
... In addition, our integrative analyses led to the identifica- tion of two novel targets for therapy: BCMA and CCR8. BCMA was identified using a network reconstruction approach and validated in 11 independent ...
17
HIV-1 selectively targets gut-homing CCR6+CD4+ T cells via mTOR-dependent mechanisms
... HIV targets upon recruitment into the intestine and pro- vide a detailed molecular explanation for preferential HIV/SIV replication and persistence in gut-homing CCR6 + CD4 + T cells (24, 25, 37, ...
22