telomere length
Telomere length and bipolar disorder
... Telomere length was shorter in first-degree relatives compared with unrelated healthy comparison individuals, potentially reflecting the cumulative lifetime burdens of genetic and environmental ...shorter ...
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Obesity and Telomere Length: Does the Obesity Paradox Exist?
... The telomere length was measured using the monochrome multiplex quantitative PCR ...the telomere length was measured. The length of the telomere was calculated by dividing the ...
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The association of telomere length with substance use disorders: systematic review and meta-analysis protocol
... reporting telomere length in adult patients with substance use disorder compared with a control ...be telomere length in adults with substance use disorder (primary) and, specifically, in ...
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Telomere length and survival in primary cutaneous melanoma patients
... the telomere length and age interaction on patient survival, a Cox regression model was imple- mented using telomere length and age as main effects and telomere length * age as ...
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Distribution of Telomere Length in the Cord Blood of Chinese Newborns
... placental telomere length and telomerase activity ...in telomere length for the FGR cord blood samples, leading them to conclude that the pathology is placental in ...and telomere ...
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Heregulin, a new regulator of telomere length in human cells
... in telomere homeostasis, we undertook a multi-step ...both telomere length dynamics and telomere-binding protein expression, we introduced additional copies of HRGβ2 into HRGβ2- negative MCF-7 ...
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A quantitative PCR method for measuring absolute telomere length
... absolute telomere length (aTL) using quantitative real- time polymerase chain reaction ...of telomere length (TL) but modified by introducing an oligomer standard to measure ...
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Correlation of cord blood telomere length with birth weight
... qPCR telomere length which measures the true length of the telomere hexam- ...As telomere length is a reflection of replicative his- tory, the shorter telomeres could be a ...
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Association of peripheral leukocyte telomere length and its variation with pancreatic cancer and colorectal cancer risk in Chinese population
... In this study, we conducted a nested case–control study in a Chinese population and evaluated the relationships between relative LTL, TLV and risk of pancreatic cancer and CRC. Our results showed that either short or ...
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Frailty is associated with the epigenetic clock but not with telomere length in a German cohort
... Description of study population and main variables Major characteristics of the study populations are shown in Table 1. The two ESTHER subsets analyzed in the present work—dataset 1 consisting of 1000 consecutively ...
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Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools
... in telomere length ...the telomere lengths of strains in the yeast gene deletion library (Gatbonton et ...between telomere length homeostasis and regulation of dNTP ...
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Genetic Architecture of Natural Variation of Telomere Length in Arabidopsis thaliana
... protection. Telomere length is known to be highly heritable and is derived from a homeostatic balance between telomeric lengthening and shortening ...underlying telomere length homeostasis, ...
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The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length
... Notably, telomere-length estimates are averaged across all chromosomes, as no specific data about any one particular telomere is ...underestimate telomere length. We used the weighted ...
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Telomere length shows no association with BRCA1 and BRCA2 mutation status
... This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation carriers and controls. The first group was a ...
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Telomere length and common disease: study design and analytical challenges
... Iles MM, Bishop DT, Taylor JC, Hayward NK, Brossard M, Cust AE, Dunning AM, Lee JE, Moses EK, Akslen LA; AMFS Investiga- tors, Andresen PA, Avril MF, Azizi E, Scarrà GB, Brown KM, De˛bniak T, Elder DE, Friedman E, ...
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The polygenic nature of telomere length and the anti-ageing properties of lithium
... in telomere length regulation, ...top telomere SNP rs10936599 on the expression of the most signi fi cantly enriched gene LRRC34, in transformed fi broblasts, adipose tissue, tibial nerve, heart, ...
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Normal Telomere Length Maintenance in Saccharomyces cerevisiae Requires Nuclear Import of the Ever Shorter Telomeres 1 (Est1) Protein via the Importin Alpha Pathway
... Telomere length analysis by ligation-mediated PCR. After ACY1563 was transformed with pRS413- or pRS423-derived constructs, transfor- mants were restreaked for ⬃ 150 generations at 25°C or 35°C on solid ...
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Telomere length, pre eclampsia, and gestational diabetes
... that telomere length will also differ in patients with these ...addition, telomere length has been associated with oxidative stress, [16,27] and markers of oxidative stress are raised in pre- ...
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Father Loss and Child Telomere Length
... salivary telomere length (sTL) data and who have had some contact with their biological fathers since birth (n = 2437) and (2) a subsample of children whose parents were living together (married or ...
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Role of TERRA in the Regulation of Telomere Length
... maturation. Telomere shortening occurs when Thp2, a subunit of the THO complex, is ...the telomere end-trimming enzyme Exo1 that induces telomere shortening ...and telomere loss in the absence ...
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