tetrachlorodibenzo-p-dioxin
Consequences of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on Hepatic Stellate Cell Activation and Extracellular Matrix Remodeling During Chronic Liver Injury
... 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental pollutant and high-affinity ligand for the aryl hydrocarbon receptor (AhR). Exposure to TCDD elicits a spectrum of toxic ...
117
Consecutive changes of heat shock protein 70 during tcdd(2,3,7,8 tetrachlorodibenzo p dioxin) toxicity in rat testis
... Materials and Methods: Four week old 30 male Sprague-Dawley rats were divided into 10 groups. Group I, II, III received TCDD(2,3,7,8-tetrachlorodibenzo-p-dioxin) 40μg intraperitoneally and were ...
5
In Utero Exposure to 2,3,7,8 Tetrachlorodibenzo p Dioxin Affects the Development of Reproductive System in Mouse
... Fig. 2. Effects of in utero TCDD exposure on expression of androgen receptor. Pre- gnant mice were injected with 1 g/kg μ TCDD concentration on GD 15. Testes on PND 30 and PND 60 were used to examine the expression of ...
8
Identification and characterization of long non-coding RNAs in porcine granulosa cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
... 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD), a chlori- nated xenobiotic and a member of the polycyclic aromatic hydrocarbon (PAH) family, is a by-product of human activity including herbicide ...
13
Co-expression of the aryl hydrocarbon receptor and estrogen receptor in the developing teeth of rat offspring after rat mothers’ exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and the protective action of α-tocopherol and acetylsalicylic acid
... Background. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can cause adverse effects in many or- gans. Toxic effects are caused due to the formation of a TCDD complex with the cytoplasmatic ...
8
A Parameter Analysis of a Physiologically Based Pharmacokinetic (PBPK) Model Describing the Movements of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Mouse
... toxic dioxin molecule, 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD), in humans has been estimated to be between seven and eleven years ...
69
Schulz, Melanie (2011): Quantitative proteomic analysis of early phosphorylation changes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in 5L rat hepatoma cells. Dissertation, LMU München: Fakultät für Biologie
... the dioxin the molecular mechanism is still ...of dioxin action, a global quantitative mass spectrometric analysis of the alterations of protein phosphorylation pre- ceding the alterations in gene ...
184
Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible genes in human amniotic epithelial cells
... Sequence Detection System (Applied Biosystems; Foster City, CA), according to the manufacture's instructions. PCR reaction involved template cDNA samples, Advan- tage Taq Plus DNA polymerase (Clontech Laboratories, Inc.; ...
9
Dioxin-like activities in serum across European and Inuit populations
... and dioxin-like compounds (DLCs) such as non-ortho and mono-ortho PCBs may cause a series of negative effects both in animal experiments and in human epidemiologic studies including carcinogenicity [11], ...
13
Polychlorinated dioxins, furans, and biphenyls in blood of children and adults living in a dioxin-contaminated area in Tokyo
... blood dioxin concentrations and the health examination of inhabitants in this contaminated ...blood dioxin concentrations were associated with contaminated soil in terms of congener/isomer pat- ...blood ...
10
Chlorinated Dioxin and Furan Congener Profiles from Pentachlorophenol Sources
... Technical-grade pentachlorophenol contains a considerable amount of im- purities, such that the product typically sold as “pentachlorophenol” was only about 90% - 92% PCP [1]. The most abundant impurities are lower ...
15
Neurodevelopmental toxicity of prenatal polychlorinated biphenyls (PCBs) by chemical structure and activity: a birth cohort study
... Then multiple linear regression models were devel- oped with a broad inclusion of all covariates showing an association with the PDI or MDI of p < 0.3. We used a backward elimination approach and a ...
13
Change in decay rates of dioxin-like compounds in Yusho patients
... of dioxin and dioxin- like ...and dioxin-like compounds in the environment subsequently ...and dioxin-like compounds in the envir- onment have decreased [10, 19, ...
7
A GIS study of dioxin contamination in a Vietnamese region sprayed with herbicide
... Orange dioxin into humans in Vietnam whereby the dioxin present in soil and sediment is taken up by farm animals after initial incorporation into duck and fish ...the dioxin upon consumption of ...
8
Spatial variations in the incidence of breast cancer and potential risks associated with soil dioxin contamination in Midland, Saginaw, and Bay Counties, Michigan, USA
... of dioxin is ...The dioxin data had significant number of out- liers with extremely high TEQ values even after log trans- formation of the data, thus remaining outliers and nonhomogeneous variations between ...
19
Polychlorinated Dibenzofurans and Dibenzo p Dioxin in Tree Bark from an Industrialized Area: What the 2,3,7,8 Cl Substituted Congeners Tell Us, and What Is Missing
... We analyzed polychlorinated dibenzofurans (PCDF) and dibenzo-p-dioxins (PCDD) in 27 tree bark samples from the industrialized area near Sauget, Illinois, USA. The trees were located within 4 km of the W. G. ...
7
Association between dioxin concentrations in breast milk and food group intake in Vietnam
... of dioxin contamination in food eaten by the Vietnamese people carried out by Schecter et ...reported dioxin in samples of soil, food, human blood, and breast milk in southern Vietnam, even though the Agent ...
9
Ethics issues experienced in HBM within Portuguese health surveillance and research projects
... Communicating or not the dioxin or heavy metal load in human milk (ProVEpA and human milk survey) is a sen- sitive issue which must be approached particularly care- fully. The benefits of breast-feeding are so ...
7
COMPARATIVE CHARACTERISTICS OF HEALTH STATUS OF PARENTS
... of dioxin in the pediatric group is 55 pg per gram of blood lipid that is 2 times greater than the background index of the Russian Federation population (6) ...
5