TGF-β1/Smad
Original Article Clearing heat and promoting diuresis method on TGF-β1/Smad signal pathway in airway remodeling of asthmatic rats
... of TGF-β1 signal pathway, can directly transmit the signal from cell membrane to nucleus and mediate the conduction of TGF-β1 intracellular ...in TGF-β1/ Smad signal ...
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Original Article TGF-β1/Smad signaling, MMP-14, and MSC markers in arterial injury: discovery of the molecular basis of restenosis
... while TGF-β1/Smad signaling ...as TGF-β, which is associated with cell migration in skin and cornea wound healing ...through TGF-β1/ Smad2 signaling [23]. Moreover, the ...
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Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling
... affect TGF-β1 prometastatic ...the TGF-β1-responsive PDAC cell lines Panc-1 and ...increased TGF-β1/Smad-dependent migratory activities in H6c7, Colo357, and Panc- 1 ...
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Herbal compound 861 prevents hepatic fibrosis by inhibiting the TGF β1/Smad/SnoN pathway in bile duct ligated rats
... that TGF-β1 is the most po- tent cytokine fostering hepatic fibrosis; through Smad2 and Smad3 phosphorylation, it activates HSCs to pro- duce collagen III and ...ceptor, TGF-β1 activates ...
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TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5
... of TGF-β1, type I and type II TGF-β1 receptors activate SMAD2/3 ...[15]. TGF-β1 sig- naling has been shown to play a pivotal role in down-reg- ulating chemokines and chemokine ...
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Original Article Effects of swertiamarin on TGF-β1/Smad signaling pathway in rats with carbon tetrachloride-induced liver fibrosis
... and TGF-β1 in the liver, and the mRNA expressions of these genes were determined in the liver by real time ...and TGF-β1 expression were decreased with SM ...and TGF-β1 in the ...
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Investigating the effects of Pirfenidone on TGF β1 stimulated non SMAD signaling pathways in Dupuytren’s disease derived fibroblasts
... proliferation in both carpal tunnel (CT) - and DD-derived fibroblasts, but that the effect was more pronounced in DD-derived fibroblasts [21]. Several stud- ies have reported the effects of PFD on fibroblasts de- rived ...
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Original Article The protective effects of melatonin on peritoneal fibrosis induced by high glucose peritoneal dialysis in rats
... of TGF-β1, Col-I and α-SMA were significantly more increased in the model group than they were in the control ...peritoneal TGF-β1 and p-Smad 2/3 were significantly increased and that ...
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The effect of transforming growth factor-β1 on nasopharyngeal carcinoma cells: insensitive to cell growth but functional to TGF-β/Smad pathway
... the TGF-β/Smad signaling function including defects in TGF-β receptors and/or downstream signal molecular Smad proteins is associated with tumor progression, and specific defects in this ...
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Original Article Triptolide inhibits lipopolysaccharide-induced proliferation, induces apoptosis and causes cell cycle arrest of human mesangial cells in vitro
... that TGF-β1 has an important role in renal fibrosis, predominantly through a Smad signal transduction pathway-dependent mech- anism, but the relationship between the TGF- β1/Smad ...
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Original Article Knockdown of elF3a inhibits collagen synthesis in renal fibroblasts via Inhibition of transforming growth factor-β1/Smad signaling pathway
... them, Smad signaling is recognized as a major pathway of TGF-β1 signaling in progressive renal ...blocking TGF-β1 with neutralizing antibody, antisense oligonucle- otides, inhibitors, ...
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Label-free quantitative proteomics identifies transforming growth factor β1 (TGF-β1) as an inhibitor of adipogenic transformation in OP9-DL1 cells and primary thymic stromal cells
... and Smad proteins binding to the promoter region of target genes are required for the TGF-β-mediated tran- scriptional activity ...5 TGF-β1 promoted nuclear translocation of β-catenin in ...
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Distinct mechanisms of TGF β1–mediated epithelial to mesenchymal transition and metastasis during skin carcinogenesis
... the ability to move out of the primary lesion, local proteinases and angiogenesis play crucial roles in distant metastasis formation. To this end, both the RhoA/Rac and the MAPK pathways have been doc- umented to induce ...
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Rapamycin Inhibits Transforming Growth Factor β1 Induced Fibrogenesis in Primary Human Lung Fibroblasts
... in TGF-β1- induced ...of TGF-β1-induced collagen secretion is suggested as ...First, TGF-β1 increases collagen gene and protein expression through the mTOR/p70S6K ...antagonizes ...
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T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer
... of TGF-β1 are also associated with T cell dysfunction in cancer patients where it is a negative prognostic ...indicator[26]. TGF-β is a family of three isoforms comprising TGF-β1, 2 and ...
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Blocking Smad7 restores TGF β1 signaling in chronic inflammatory bowel disease
... the Smad family of proteins. We show here that Smad7, an inhibitor of TGF- β 1 signaling, is overex- pressed in inflammatory bowel disease (IBD) mucosa and purified mucosal T ...exogenous TGF- β 1. ...
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Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5
... of TGF-β ...and Smad binding- competent mutant of ALK5, but not a Smad-binding- defective derivative, was capable of rescuing PAR2 deficient cells from becoming refractory to TGF-β1- ...
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Original Article Cross-talk between TGF-β/Smad pathway and Wnt/β-catenin pathway in pathological scar formation
... Abstract: TGF-β1 is a key factor in the process of wound healing, which is regulated by TGF-β/Smad ...that TGF-β1 contributed to pathological scar ...evaluating ...
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Original Article TGF-β promotes invasion and angiogenesis of oral squamous cell carcinoma SCC9 cells by upregulation of slug signal
... Abstract: TGF-β1 is involved in the metastasis, angiogenesis and progression of various carcinomas, including oral squamous cell carcinoma (OSCC), and its mechanism remains largely ...that ...
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Naringenin prevents TGF β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation
... of TGF-β1 is due to blocking the transport of TGF-β1 from the TGN to the plasma mem- ...and TGF-β1 by ...of TGF-β1, indicating that more TGF-β1 was ...
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