Th, helper T cell
Biochemical basis of synergy between antigen and T helper (Th) cell mediated activation of resting human B cells
... B cell activation in order to investigate the biochemical basis for synergy between antigen and T helper (Th) cells in the activation of resting human B ...specific Th-B cell ...
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Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E knockout mice
... and T lymphocytes. We have studied immune cell activa- tion and the autoimmune response to oxidized LDL in ath- erosclerotic apo E–knockout ...of T cell help, and the increase in antibody ...
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Transcriptional Regulation of T Helper 17 Cell Differentiation
... induces Th cell activation and ...RORγ t (also RORa) ...RORγ t activity and Th17 cell ...While T-bet and Ets-1 antagonize RORγ t activity and thus function as suppressors ...
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Disrupted balance of CD4+ T-cell subsets in bone marrow of patients with primary immune thrombocytopenia
... of T helper 22 (Th22), Th17, Th1, Th2, follicular T helper (Tfh) cells and regulatory T cells (Tregs) as well as their effector cytokines in BM and PB from active ITP patients and ...
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Regulatory T cells can migrate to follicles upon T cell activation and suppress GC Th cells and GC Th cell–driven B cell responses
... the helper activity of the T cells in GCs (GC-Th cells) remains poorly ...a T cell subset in human tonsils that displays potent suppressive activities toward GC-Th ...
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Major peptide autoepitopes for nucleosome specific T cells of human lupus
... pathogenic Th cells may become diverse with “epitope spreading” as the disease progresses (34), primary immunodominant autoepitopes could be identified, probably owing to the considerable cross-reactivity that ...
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Local Expression of T Cell Subsets in Sensitized and Unsensitized Experimental Cystic Echinococcosis.
... in Th cell differentiation (Levy and Darnell, 2002; Zhu et ...Th1 cell differentiation (Uemura et ...regulatory T cells (Babu et al. 2005). In addition to cytotoxic T cell which ...
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Vaccine efficacy and T helper cell differentiation change with aging
... these Th subsets within the spleens of influenza infected mice show that on both 7 and 14 dpi within the total CD4 population and the NP-specific CD4 population, skewing towards Th1 is more prevalent in the young ...
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Identification of a T-helper cell epitope on the rotavirus VP6 protein.
... the Th cells against VP6, we generated two Th-cell hybridomas directed against conserved epitopes on the VP6 molecule of two viral strains, YM and ...
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Mercuric chloride, a chemical responsible for T helper cell (Th)2 mediated autoimmunity in brown Norway rats, directly triggers T cells to produce interleukin 4
... II T cells present in both ...purified T cells exposed to HgCl2 expressed high levels of IL-4 ...other T helper cell 2 cytokines were produced, there was also a concomitant decrease in ...
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Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment
... The Th differentiation pathway (Ingenuity® Systems [34]), where GWAS genes (grey), growth factors (squares), transcription factors (broad ovals), complexes (standing ovals), and receptors (double standing ovals) ...
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Decoy receptors in the regulation of T Helper cell type 2 response
... the Fc domain has been shown to slow in vivo clearance of TNFR-Fc fusion proteins. Now that this novel regulatory role for IL-13R 2 has been identified, it will be important to address the mechanism by which this ...
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T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses.
... Depletion of T4+ cells caused a pronounced suppression of antiviral antibody response 20-fold decrease but had minimal effect on virus-specific CTL response 90% of T helper cells, anti-L[r] ...
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Alterations in cytotoxic and helper T cell function after infection of T cell clones with human T cell leukemia virus, type I
... this helper function became independent of DPw2-stimulation and persisted even when the cytotoxic activity was ...OKT4+ T cell clone thus could simultaneously manifest both cytotoxic and ...
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HIV integrase and the swan song of the CD4 T cells?
... pre-B cell lines This death was proposed to be due to a defect in DNA-PK in these cell lines, resulting in a lack of DNA repair needed to complete the retroviral ...retrovirus-induced cell death ...
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Induction of rabies virus-specific T-helper cells by synthetic peptides that carry dominant T-helper cell epitopes of the viral ribonucleoprotein.
... To determine whether RNP-specific T-helper cells cross-reacted with the RNP or N protein from different rabies or rabies-related viruses, BALB/c mice were immunized with ERA BPL s.c., an[r] ...
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T cell receptor independent immunosuppression induced by dexamethasone in murine T helper cells
... The immune and inflammatory responses are largely inhibited by glucocorticosteroids. In thymocytes, for example, glucocorticosteroids cause apoptosis, whereas they suppress the activity of phospholipase A2 and the ...
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Immunoregulatory T Cell Function in Multiple Myeloma
... B cell differentiation and immunoglobulin ...B cell differentiation assays, proliferation and polyclonal immunoglobulin secretion optimally requires T cell help and can be inhibited both by ...
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Ogrinc, Ana (2017): Genetic background profoundly influences colitis susceptibility. Dissertation, LMU München: Medizinische Fakultät
... Germany), cell counter (CASY cell counter and analyzer, OMNI life science, Bremen, Germany), centrifuge (Rotixa RP, Hettich, Tuttlingen, Germany), chemical scale (Kern, Alb- stadt, Germany), ELISA-reader ( ...
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CD4 T follicular helper cell dynamics during SIV infection
... CD4 T cells or portions of CD4 T cell plasma membranes, and watershed segmentation algorithms in Imaris were applied to the CD4 ...B cell follicle of each surface was ...
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