Th1, T helper 1
Interleukin-22 Promotes T Helper 1 (Th1)/Th17 Immunity in Chlamydial Lung Infection
... The role of interleukin-22 (IL-22) in intracellular bacterial infections is a controversial issue, although the contribution of this cy- tokine to host defense against extracellular bacterial pathogens has been well ...
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Determinant in Human Immunodeficiency Virus Type 1 for Efficient Replication under Cytokine-Induced CD4+ T-Helper 1 (Th1)- and Th2-Type Conditions
... IL-12-induced Th1-type culture, in contrast to NCN-SM, which could not efficiently ...duced Th1-type culture indicated that the V3 loop sequence of M-tropic HIV-1 may be necessary for efficient ...
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Imbalanced shift of cytokine expression between T helper 1 and T helper 2 (Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel syndrome
... The results of RT-PCR assays showed that IFN-γ levels were significantly higher in the intestinal mucosa of PI- IBS patients (0.47 ± 0.02) than that in non-PI-IBS patients (0.32 ± 0.02) or healthy people (0.31 ± 0.02) ...
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Cellular Immune Responses to Recombinant Mycobacterium bovis BCG Constructs Expressing Major Antigens of Region of Difference 1 of Mycobacterium tuberculosis
... difference 1 (RD1), such as pe35, cfp10, and ...selected T helper 1 [Th1], Th2, and anti-inflammatory cytokines, ...in Th1 cell assays that correlate with protective cellular ...
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Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN gamma secreting TH1 cells in humans
... ducing T helper 2 (TH2)-type cells in the anti-CD4 treated group was observed, numbers of IFN- g –producing T helper 1 (TH1)-type cells remained stable, resulting in a ...
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<em>Chlamydia trachomatis</em> recombinant MOMP encapsulated in PLGA nanoparticles triggers primarily T helper 1 cellular and antibody immune responses in mice: a desirable candidate nanovaccine
... potentiates T helper 1 (Th1) immune responses induced by a peptide derived from the recombinant major outer membrane protein (rMOMP) of Chlamydia trachomatis, and may be a promising vaccine ...
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T-helper 1 versus T-helper 2 lymphocyte immunodysregulation is the central factor in genesis of Burkitt lymphoma: hypothesis
... the TH1 immune response resulting in inefficient tumour cellular surveillance, is the cause of Burkitt lym- ...and TH1 immune profile, may be "protective" against development of Burkitt lym- ...
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Local Expression of T Cell Subsets in Sensitized and Unsensitized Experimental Cystic Echinococcosis.
... promoting Th1 cell differentiation (Uemura et ...regulatory T cells (Babu et al. 2005). In addition to cytotoxic T cell which is known as cytotoxic T lymphocyte, cytolytic T cell, CD8+ ...
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Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in Helicobacter-infected BALB/c mice
... a T helper 1 (Th1) cytokine, is required for the development of severe pathology induced by chronic Helicobacter ...polarised Th1 responses ...
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Autophagy enhances mesenchymal stem cell-mediated CD4+ T cell migration and differentiation through CXCL8 and TGF-β1
... + T cells ...recruit T leukomonocytes, monocytes, ...+ T cells, as they are critical effectors of the immune adaptive response ...+ T cells can prolifer- ate and differentiate into various ...
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Frequencies of Circulating Th1-Biased T Follicular Helper Cells in Acute HIV-1 Infection Correlate with the Development of HIV-Specific Antibody Responses and Lower Set Point Viral Load
... Perturbation of circulating Tfh cells during acute HIV-1 infection. Having es- tablished the normal frequencies and phenotypes of circulating Tfh cells, we next investigated how acute HIV infection alters the ...
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A multidrug resistance protein (MRP) like transmembrane pump is highly expressed by resting murine T helper (Th) 2, but not Th1 cells, and is induced to equal expression levels in Th1 and Th2 cells after antigenic stimulation in vivo
... CD4 1 cells proved to be a potent method to select for parasite-specific Th1 or Th2 cells, respectively ...antigen-triggered Th1 or Th2 cells ex vivo ac- cording to a functional parameter, ...
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Plasma levels of monokine induced by interferon-gamma/chemokine (C-X-X motif) ligand 9, thymus and activation-regulated chemokine/chemokine (C-C motif) ligand 17 in children with Kawasaki disease
... AST: Aspartate aminotransferase; C: Cys; CAA: Coronary artery aneurysm; CAL: Coronary artery lesions; CC: Cys-Cys; CK-MB: Creatine kinase-MB; CRP: C-reactive protein; CXC: Cys-X-Cys; CX3C: Cys-X-3Cys; EDTA: Ethylene ...
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Follicular helper T cell signature in type 1 diabetes
... of T cell differentiation as a Th1/Th2 dichotomy, with Th1 cells responsible for tissue-specific autoimmunity, has led numerous researchers to hunt for a Th1 signature in T1D, with widely ...
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Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer
... differentiation; Th1: type 1 T helper; PD‑L1: programmed cell death ligand‑1; PD‑1: programmed cell death protein‑1; TIL: tumor infiltrating lymphocyte; TIM: ...
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Mesenchymal stem cells: a promising way in therapies of graft-versus-host disease
... vesicles; Th1: T helper cells 1; aGVHD: Acute graft-versus-host disease; Th2: T helper cells 2; APC: Antigen presenting cells; CsA: Cyclosporine A; IL-2: Interleukin 2; Treg: ...
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A melanoma helper peptide vaccine increases Th1 cytokine production by leukocytes in peripheral blood and immunized lymph nodes
... Intracellular cytokine (ICC) production by proliferating cells was determined on peptide-stimulated CFSE-labeled PBMC after phorbol 12-myristate 13-acetate (PMA; 40 ng/ml; Sigma-Aldrich) plus ionomycin (1 μM; ...
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Multiple myeloma presenting as cutaneous leukocytoclastic vasculitis and eosinophilia disclosing a T helper type 1/T helper type 2 imbalance: a case report
... CD8 T cells, and repair T-helper sub- sets with the Th1/Th2 response ...of Th1 cytokines (IFN-γ) were sig- nificantly reduced, while the levels of Th2 cytokines (IL-4, IL-5, and IL-6) ...
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The role of follicular helper CD4 T cells in the development of HIV 1 specific broadly neutralizing antibody responses
... (Fig. 1) [20, ...CD4 T-cell lineages [26, ...as Th1, Th2, Th17 and regulatory T cells [28, ...the T cell zones sur- rounding the lymphoid follicles [30] and continues at the follicular ...
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Novel Role of CD8+ T Cells and Major Histocompatibility Complex Class I Genes in the Generation of Protective CD4+ Th1 Responses during Retrovirus Infection in Mice
... Treatment of mice with antibodies. The anti-IFN-␥ (XMG1.2)-producing hy- bridoma (American Type Culture Collection [ATCC]), the anti-IL-10 receptor (anti-IL-10R; 1B1.3a)-producing hybridoma (generous gift from Robert ...
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