Thalassemia intermedia
Comparison of Cardiac Function in Young Patients with Thalassemia Intermedia and Healthy Individuals Using Echocardiography Method
... Islands. Thalassemia is of two major types namely Alpha and Beta in which the alpha and beta globin chains are ...Beta thalassemia intermedia ...
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Haematological and Genetic Characterization of Thalassemia Intermedia in Tank and South Waziristan Agency of Khyber Pakhtun Khwa
... β thalassemia intermedia do not require blood transfusion except when they develop infections, which augment .... Thalassemia intermedia is a rare condition and very little work has been done ...
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Evaluation of Cardiac Function in Patients with Thalassemia Intermedia
... It can be concluded that systolic and diastolic performance of thalassemia intermedia patients is affected in comparison with control group due to parameters including MPI, LVMI, IRT, EF, FS, IVSD and ...
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Thalassemia Intermedia; Folic Acid and Vitamin B12 Supplementation. What We Know and What is Needed?
... Beta thalassemia is a common genetic disorder which results from beta globin chain synthesis ...beta thalassemia is divided into three main subgroups; thalassemia minor, thalassemia ...
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Dysregulation of the RANKL/RANK/OPG axis in thalassemia intermedia patients
... Thalassemia intermedia (TI) is a term that describes β thalassemia patients in which the manifestations range in severity between β thalassemia major (TM) and β thalassemia trait [1, ...
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In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia
... lethal thalassemia major are complicated by the fact that human γ-globin is strongly prone to form possibly deleterious γ4 homo- tetramers in transgenic mice due to a relative inefficiency of hybrid mouse ...
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Hb Knossos (HBB: c.82G > T), β-globin CD 5 (−CT) (HBB: c.17_18delCT) and δ-globin CD 59 (−a) (HBD: c.179delA) mutations in a Syrian patient with β-thalassemia intermedia
... Hemoglobin A2 (Hb A2), is a minor adult hemoglobin, its levels ranged between (2–3.2%) of the total circulating haemoglobin in healthy adults [10]. The increase in Hb A2 level more than borderline levels is the most ...
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Molecular characterization of β-thalassemia intermedia in the West Bank, Palestine
... eight thalassemia centers in the major hospi- tals administered by the Palestinian Ministry of Health (MOH) in the West Bank were ...all thalassemia patients and identified 70 potential TI pa- tients from ...
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Thalassemia: A Review
... The thalassemia is a group of inherited hematologic disorders caused by defects in the synthesis of one or more of the hemoglobin ...Alpha thalassemia is caused by reduced or absent synthesis of alpha ...
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Beta-thalassemia
... of thalassemia minor subjects is ...with thalassemia intermedia who do not usually have severe hemosiderosis are less prone to cardiac prob- lems ...
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Bone Mineral Density in β Thalassemia Major and Intermedia, Correlation with Biochemical and Hormonal Profiles
... In thalassemia major, mean age was 14 ± ...with thalassemia intermedia was ...of thalassemia major and 35% of thalassemia intermedia; but hypothyroidism, diabetes mellitus, and ...
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Salivary ferritin and iron as a marker and new discriminating indices between iron deficiency anemia and thalassemia: a meta-analysis
... Case-control studies were included in the evaluation since this study design allows a comparison to be made between the affected individuals and healthy or disease-free ones, which is essential for the meta-analysis ...
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... Extramedullary hematopoiesis (EMH) is a compensatory mechanism that occurs in patients with hematological dysfunction such as Thalassemia Major or Thalassemia Intermedia and Sickle Cell Anemia [6], ...
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Increased mitochondrial DNA deletions and copy number in transfusion-dependent thalassemia
... While this study is limited by its cross-sectional design, we describe a new marker of mitochondrial damage in thalassemia that can be easily followed over time in clinical samples and can predict the risk of ...
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THALASSEMIA IN NEGROES
... old mother, an American Negro, showed numerous target cells, hypochromia and abnormal fragility.. She exhibited no hematologic response to a 2 wk, trial on iron therapy.[r] ...
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... This prospective family study is based on nine index cases of sickle cell-beta-thalassemia and seven index cases of hemoglobin-E-beta- thalassemia. They were selected out of 1500 routinely referred cases, ...
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MOLECULAR STUDIES ON THE DIST RIBUTION OF β - THALASSEMIA IN IRAN: THE BASIS FOR PRENATAL DIAGNOSIS
... Regarding the spectrum of mutations whicll differs considerably between different ethnic groups, many exmnples could be mentioned. For exmnple, in Smdinia. Ole codon 39{Crr) nonsense mutation can be found in about 95% of ...
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Phosphaturia in Thalassemia
... in four thalassemic children aged 6 to 10 years. No correla- tioi was found between phosphorus intake and serum level or betwceii 1)liosPliortts intake and net absorption. There was a po[r] ...
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Relationship of Thyroid Hormone Status with Iron Overload in the Βeta-Thalassemic Tribal Children Receiving Multiple Blood Transfusions- A Cross-Sectional Descriptive Study
... Thalassemia, a major public health problem in India, especially in tribal populations, is an autosomal recessive inherited blood disorder in which blood transfusion is the mainstay of treatment which in turn may ...
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Heterozygous Beta Thalassemia in Parents of Children with Beta Thalassemia Major
... A total of 100 families of known thalassemia major children were selected whose parents and grand parents (both maternal and paternal) were alive. They belonged to district Peshawar. All were thoroughly ...
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