The Aldose reductase pathway:
Benzopyrazines: Synthesis, Characterization and Evaluation as Aldose Reductase Inhibitors
... of aldose reductase (ALR2) in diabetic complications such as retinopathy, nephropathy, neuropathy, and cataract ...polyol pathway reduces glucose to sorbitol whose elevated level leads to diabetic ...
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Inhibitory activities of selected Kampo formulations on human aldose reductase
... polyol pathway, previous studies have reported that the inhibition of AR is involved in the action of Kampo medicines that are used for treat- ment of DN including Goshajinkigan, Hachimijiogan, Sokeikakketuto and ...
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Aldose Reductase Inhibitors as Potential Therapeutic Drugs of Diabetic Complications
... Consistent findings can be also traced in the animals with a deficient AR gene expression. In db/db mice with an AR null mutation, diabetes-induced reduction of platelet/endothelial cell adhesion molecule-1 expression ...
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Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice
... Our data suggest that hyperglycemia by itself promotes athero- sclerosis in a setting of increased hAR expression. The development of accelerated vascular disease in diabetes may be explained by glu- cose flux through ...
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Polyol pathway and diabetic nephropathy revisited: Early tubular cell changes and glomerulopathy in diabetic mice overexpressing human aldose reductase
... polyol pathway might exert the release of free radicals, perhaps by downregulating glutathi- one synthesis through the consumption of niconinamide ade- nine diphosphate (NADPH), resulting in cellular injury 16,17 ...
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Constituents of the Stem of Angelica gigas with Rat Lens Aldose Reductase Inhibitory Activity
... lens aldose reductase, stem Acceleration of the polyol pathway [Yabe-Nishimura, 1998], nonenzymatic glycation [Friedman, 1999], activation of protein kinase C [Koya and King, 1998] and oxidative ...
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Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats
... sorbitol pathway fructose levels rise in various tissues in ...an aldose reductase inhibitor known to lower tissue fructose concentration, to experimental diabetic rats led to a decrease in the ...
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Crystal structures of Aldose Reductase, C2A domain of Rabphilin3A and tests of new restraints
... of Aldose Reductase (an enzyme implicated in the polyol pathway) is ...various Aldose Reductase high resolution structures reveals a domain movement that has been called "tongs ...
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Inhibitory activity of leaf extract of Tinospora cordifolia and magnoflorine on aldose reductase for control of diabetes
... Aldose reductase catalyzes the reduction of glucose to sorbitol in the presence of cofactor NADPH, which results in oxidation of NADPH to NADP + in the polyol ...This pathway is an alternative route ...
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Aldose reductase mediates endothelial cell dysfunction induced by high uric acid concentrations
... Our previous study proved high concentration of uric acid caused abnormal sodium-calcium exchanger of mitochondria then induced the ROS production [14], which will further increase AR expression and these may be locked ...
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Aldose Reductase Deficiency Significantly Ameliorates Development of Diabetic Nephropathy in C57BL/6 mice
... Background Aldose reductase (AR) is the first enzyme in the polyol pathway that has been shown to play important roles in the pathogenesis of diabetic complications such as diabetic neuropathy and ...
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Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane
... platelets, aldose reductase synergistically modulated platelet response to both hyperglyce- mia and collagen exposure through a pathway involving ROS/PLCγ2/PKC/p38α ...
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Estimation of Aldose Reductase Activity and Malondialdehyde Levels in Patients with Type 2 Diabetes Mellitus
... polyol pathway is the major cause of hyperglycemic oxidative stress in the tissue 37 ...polyol pathway that converts sorbitol to fructose, also contributes to oxidative stress, most likely because depletion ...
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Synthesis and Biological Evaluation of Some New Rhodanine Analogues as Aldose Reductase Inhibitors (ARIs)
... complication. Aldose reductase, the rate-limiting enzyme of the polyol pathway, plays a key role in the treatment of diabetic ...as aldose reductase ...
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Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury
... Taken together, these findings provide evidence for the role of ERK1/2 pathway in the development and progression of DN. Findings from this study indicate that exposing tubular cells to high glucose concentrations ...
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In silico identification of inhibitors targeting aldose reductase found in Vitis vinifera A probable mechanistic approach
... main pathway via which Vitis vinifera may manifests its antidiabetic ...on aldose reductase, according to docking ...of aldose reductase inhibitors in diabetes [35], ...
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In silico binding and interaction studies of aldose reductase with the active components of triphala, a traditional herbal formulation
... ABSTRACT Aldose reductase is the key regulatory enzyme of the aldose reductase (AR)/polyol pathway which plays a major role in the development of diabetic ...
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Glucose specific regulation of aldose reductase in capan 1 human pancreatic duct cells In vitro
... There has been no information available on the pathogenic mechanisms through which glucose may cause inhibition of Na,K-ATPase activity in pancreatic duct cells, although studies on other tissues have demonstrated that ...
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Molecular Docking Evaluation of Some Natural Phenolic Compounds as Aldose Reductase Inhibitors for Diabetic Complications
... polyol pathway, larger production of advanced glycation end products, augmented production of diacylglycerol due to hyperglycemia, altered catabolism of extra glucose through hexosamine pathway and defect ...
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Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma
... signaling. Aldose reductase (AR), an enzyme that reduces glucose to sorbitol in the polyol pathway, has been shown to efficiently reduce lipid aldehydes and their GSH conjugates (Km lipid aldehydes ...
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