The arachidonic acid pathway
Effects of ethanol and arachidonic acid pathway inhibitors on the effectiveness of gastric mucosa cytoprotection
... uric acid due to xanthine oxidase in ischaemia and the super- oxide anion radical synthesis resulting from reperfu- sion, oxygen release of phagocytes, oesinophils and marcophages accumulated in the gastric mucosa ...
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Aqueous Ethanol Fruit Extract of Xylopia aethiopica and Xylopic Acid Exhibit Anti-inflammatory Activity Through Inhibition of the Arachidonic Acid Pathway
... In the form of a decoction, X. aethiopica is traditionally employed in the treatment of bronchitis, asthma, arthritis and rheumatism in Ghana, Nigeria and Cameroon. This study establishes the inhibitory effect of X. ...
7
Flavonolignans inhibit the arachidonic acid pathway in blood platelets
... (ASA) acid was the first cyclooxygenase inhibitor to be recognized and introduced to clinical use, and has been shown to be effective in reducing cardio- vascular disease conditions associated with thrombosis, and ...
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Relationship between arachidonic acid pathway and human renal cell carcinoma
... Cyclooxygenase (COX) is the principal target of NSAIDs. COX is the fi rst oxidase in the process of prostaglandin production from arachidonic acid. COX enzyme may be involved in the initiation and/or the ...
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Effect of DanQi Pill on PPARα, lipid disorders and arachidonic acid pathway in rat model of coronary heart disease
... Traditional Chinese medicine has been applied in the treatment of CHD for thousands of years. DQP is one of the most widely prescribed formulas and has been shown to have remarkable protective effect on ischemia heart ...
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Sex differences in the role of phospholipase A2 dependent arachidonic acid pathway in the perivascular adipose tissue function in pigs
... response to coronary artery PVAT from male arteries was inhibited by a FP receptor 24. antagonist[r] ...
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Renal Arachidonic Acid Metabolism. The Third Pathway
... The specific activity of alkaline phosphatase, a marker for proximal tubular cells, decreased threefold after separation of mTALH cells from outer medullary cells, associated with a four[r] ...
The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance
... metabolizes arachidonic acid to several unique and biologically active compounds in rabbit liver and ...metabolized arachidonic acid through cytochrome P450 pathways, yielding ...
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Arachidonic acid in Alzheimer's disease
... Therefore, other approaches are needed to explain the discrepancy between the data of the observational studies or the works on AD animal models on one hand and those of the clinical trials on the other hand. Parallel ...
6
Arachidonic acid induces macrophage cell cycle arrest through the JNK signaling pathway
... Arachidonic acid, a n-6 polyunsaturated fatty acid, has a number of biological functions, is located on the cell mem- brane and plays a key role in maintaining membrane func- tion and structure [21, ...
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A regiospecific monooxygenase with novel stereopreference is the major pathway for arachidonic acid oxygenation in isolated epidermal cells
... subjects. Cell incubation with AA (0.3-150 microM) invariably resulted in the predominant generation of a compound identified as 12-hydroxyeicosatetraenoic acid (12-HETE) by HPLC and by both negative-ion chemical ...
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Lipoxygenase Pathway in Islet Endocrine Cells OXIDATIVE METABOLISM OF ARACHIDONIC ACID PROMOTES INSULIN RELEASE
... FIGURE 7 Prevention by lipoxygenase inhibitors (ETYA or BW755c) of AA-induced insulin release at a stimulatory glucose concentration (300 mg/dl). The cells were preincubated in ETYA or B[r] ...
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A Biosynthetic Pathway Generating 12-Hydroxy-5,8,14-eicosatrienoic Acid. from Arachidonic Acid is Active in Mouse Skin Microsomes*
... 15-hydroxyeicosatrienoic acid isomers, unlike rat epidermal microsomes, which generate 15-hydroxy-5,8,11-eicosatrienoic acid from arachidonate (Van Wauwe et ...
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Arachidonic Acid Metabolism in the Neonatal Platelet
... Evaluation of the products of the lipoxygenase and cyclooxygenase pathway in the platelet of the neonate revealed an increase in the production of the lipoxygenase product HETE, whereas [r] ...
7
The role of arachidonic acid mobilisation in myeloid cells
... that arachidonic acid does not regulate NADPH oxidase activity in unprimed neutrophils but PLA] is involved in mediating the priming of NADPH oxidase activity by GM-CSF (Roberts et a i , ...
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Chemotherapy induces ovarian cancer cell repopulation through the caspase 3-mediated arachidonic acid metabolic pathway
... Several studies have recently focused on the adverse effects of chemotherapy. 5–7 These findings have demonstrated that induction chemotherapy results in an accelerated repopu- lation and measurable regrowth of ...
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Regulation of Apoptosis by Arachidonic Acid and the Adenovirus 14.7K Protein
... Research on the cytotoxic activity of TNF then became focused on understanding the differences between sensitive and resistant cells with the goal ultimately of converting tumor cells, but not normal cells, to the ...
107
Individual variation and intraclass correlation in arachidonic acid and eicosapentaenoic acid in chicken muscle
... elongase-desaturase pathway also in humans, as suggested by the much lower ALA/LA concentration ratio in human blood samples from the population in Crete, compared to olive oil ...palmitic acid, 31.0 +/- ...
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DanQi Pill protects against heart failure through the arachidonic acid metabolism pathway by attenuating different cyclooxygenases and leukotrienes B4
... calcium-signaling pathway, and aminoacyl – tRNA biosynthesis were ...significant pathway, arachidonic acid (AA) metabolism, was also identified in this ...predicted pathway alteration ...
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Successful reduction of inflammatory responses and arachidonic acid–cyclooxygenase 2 pathway in human pulmonary artery endothelial cells by silencing adipocyte fatty acid-binding protein
... AA–COX2 pathway participates in PTE-associated in- flammatory ...fatty acid that can be metabolized to diverse products depending on the expression and activity of various en- ...
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