The classical type I IFN signalling pathway
The type I IFN induction pathway constrains Th17 mediated autoimmune inflammation in mice
... though type I IFN–mediated IL-27 production plays a criti- cal role in limiting Th17 development and autoimmune response, this finding does not exclude the possibility that other cytokines, such as ...
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Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1
... produce type I interferon (IFN) to block viral ...powerful, IFN-mediated antiviral response, it is not well-defined if IAV manip- ulates the IFN receptor-mediated signaling ...of ...
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Double-Stranded RNA Induces Biphasic STAT1 Phosphorylation by both Type I Interferon (IFN)-Dependent and Type I IFN-Independent Pathways
... MAVS-dependent pathway for initial STAT1 phosphorylation following the recognition of ...transactivating type I IFN, the RIG-I-MAVS pathway might be able to directly activate ...
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Influenza C virus NS1 protein counteracts RIG I mediated IFN signalling
... of type I IFNs is essential for controlling influenza virus replica- tion and ...the IFN signalling [1,2]. RIG-I, which belongs to the DExD/H box family of RNA helicases, consists of ...
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Ross River Virus Interaction with the Type I IFN Pathways
... of type I IFN in both L929 cells and IFNAR -/- primary mouse embryonic fibroblast (MEFS) (Cruz et ...of type I ...the type I IFN ...modulate IFN. We examined ...
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Type III Interferon (IFN) Induces a Type I IFN-Like Response in a Restricted Subset of Cells through Signaling Pathways Involving both the Jak-STAT Pathway and the Mitogen-Activated Protein Kinases
... the type I or type III IFN receptor complex leads to induction of approximately the same subset of genes, one might ask why nature maintains two apparently redundant ...of type I ...
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Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction
... lates type I IFN induction by DNA viruses, such as HSV-1, through controlling the noncanonical NF-κB inducing kinase NIK ...of type I IFNs ...STING pathway appears to be ...
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Rubicon Modulates Antiviral Type I Interferon (IFN) Signaling by Targeting IFN Regulatory Factor 3 Dimerization
... virus-mediated type I IFN signaling ...virus-induced IFN-  and proinflammatory cytokine secre- tion and inhibited viral ...the IFN signaling and cellular antiviral ...
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TRAM is required for TLR2 endosomal signaling to type I IFN induction
... of type I IFN, indicating a role for TRAM in this TLR2-dependent pathway, while Staphylococcus aureus stimulated IFN-β was also ...causing type I IFN induction in ...
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NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway
... and IFN-γ production in response to ...or IFN-β production in response to ...MAPK pathway and instead is heavily dependent on the ISGF3–IFN-β ...
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Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling
... for type I IFN signalling in psoriasis pathogenesis, consistent with clinical observations that type I IFN therapy can induce or exacerbate psoriasis symptoms ...
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Adaptation at the output of the chemotaxis signalling pathway
... Here, we report that the motor itself adapts, shifting its response function according to the steady-state concentration of CheY-P. It does this by increasing the complement of FliM when the concentration of CheY-P is ...
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A role of Sirt1 in the Notch signalling pathway
... Notch signalling with basal metabolism Cells continuously change their profiles of gene expression and metabolism to adapt to the environment or developmental ...the type and quantity of metabolic pathways ...
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The WNT signalling pathway in colorectal cancer
... 35 Interestingly, the type and location of the second hit is influenced by the location of the germline mutation – a feature termed ‘interdependence’. Lamlum et al. showed that FAP patients with germline APC ...
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β-catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I/NF-κB signaling
... of IFN-β expression, we show here that β-catenin and LEF1 also activate genes of the IFN induced wave of cellular innate immune response to influenza virus infection, namely the transcription of ...
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Type I interferon pathway in adult and juvenile dermatomyositis
... of type I IFN itself in autoimmune disease are hampered by technical diffi culties of measuring type I IFN protein in the blood using standard immunoassays, which may include the ...
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Antibody independent Classical Pathway mediated Opsonophagocytosis of Type Ia, Group B Streptococcus
... clinical type Ia isolates were ...alternative pathway-mediated ...clinical type Ia isolates was mediated by the classical pathway in a nonantibody-dependent fashion was shown when ...
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Proteolysis of MDA5 and IPS 1 is not required for inhibition of the type I IFN response by poliovirus
... The type I IFN response was assessed by measuring IFN- β mRNA levels using qRT-PCR and normalizing to levels of β -actin ...the type I IFN response was examined by ...
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Type I IFN blockade uncouples immunotherapy induced antitumor immunity and autoimmune toxicity
... blocking IFN-α and IFN-β signaling completely abrogated the autoimmune side effect, without compromising antitumor efficacy, revealing the IFN-α/-β pathway as a druggable target for the ...
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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
... Apoptosis Pathway in HSC Homeostasis Deletion of Bak and Bax had no impact on the number of im- munophenotypic HSCs in the fetal liver, suggesting that the intrinsic apoptosis pathway is dispensable for HSC ...
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