The Core Promoter
Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen.
... c G-to-A point mutation at nt 1896 to abort the synthesis and secretion of HBeAg; it was detected in all four clones without mutations in the core promoter.. rarely occurs in HBV DNA clo[r] ...
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Biological Chemistry The Core Promoter and Redox-sensitive Cis -elements as Key Targets for Inactivation of the Lysyl Oxidase Gene by Cadmium
... the core promoter of the LOX gene in CdR cells Acetylation of histone N-terminal lysines is intimately linked to chromatin remodeling for transcription ...LOX core promoter in response to Cd, ...
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Core Promoter Structure in the Oomycete Phytophthora infestans
... the core promoter structure of the oomycete Phytophthora ...(nt) core sequence that overlaps the TSS in most oomycete genes. The core promoter regions of Piexo1 and Piendo1 were ...
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Core promoter acetylation is not required for high transcription from the phosphoenolpyruvate carboxylase promoter in maize
... suppress promoter activity. How- ever, histone modifications on the core promoter region, which is proximal to the transcription initiation site and which contains all binding sites for the basal ...
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Characterization of the minute virus of mice P38 core promoter elements.
... isolated promoter elements of P4 and P38 demonstrate that the Sp1 and TATA elements of P38 are not intrinsically deficient and in fact mediate mod- estly higher levels of expression than the analogous elements ...
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Transactivation of the Hepatitis B Virus Core Promoter by the Nuclear Receptor FXRα
... The functional significance of these two FXREs was inves- tigated by transient transfection in the hepatoma cell line Huh-7, demonstrating that bile acids, through FXR ␣, activate the HBV core promoter. ...
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ZEB2 inhibits HBV transcription and replication by targeting its core promoter
... to core promoter via the CACCT ...HBV core promoter was mutated, binding of ZEB2 to the core promoter was significantly reduced, although not completely ...
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Naturally Occurring Mutations Define a Novel Function of the Hepatitis B Virus Core Promoter in Core Protein Expression
... two core promoter mutations (C to T at nucleotide [nt] 1768 and T to A at nt 1770) result in enhanced viral encapsidation and ...enhanced core protein synthesis (15-fold) by the mutant ...in ...
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Core Promoter Sequences Contribute to ovo-B Regulation in the Drosophila melanogaster Germline
... the core promoter raises some but not OVO-A, on ovo-B promoter ...ovo-B promoter encodes the OVO-B isoforms re- ber of X chromosomes in the germline and the sex of quired and sufficient for ...
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Mutations in the Basal Core Promoter and Precore/Core Regions of Hepatitis B Virus in Patients Co-Infected With Human Immunodeficiency Virus
... The core promoter (CP, nt1575-1849) of the viral genome plays a significant role in HBV replication as it directs initiation of transcription for the synthesis of both the PC and pre-genomic (pg) ...basal ...
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Overlapping initiator and TATA box functions in the basal core promoter of hepatitis B virus.
... RNA core and ...basal core promoter, which contains four TA-rich sequences (TA1 through TA4) but no canonical TATA element, that can direct transcription of both ...
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Genetic variability in the precore and core promoter regions of hepatitis B virus strains in Karachi
... In some of our patients though the line probe assay could not detect a specific mutation at 1762, 1764, and 1896 position but the wild PC or BCP band was absent. The samples were retested and the control bands worked in ...
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Hypermotifs: Novel Discriminatory Patterns for Nucleotide Sequences and their Application to Core Promoter Prediction in Eukaryotes
... the core promoter region from each sequence (and the corresponding region in the non-promoter sequences), by extracting the 40 bases upstream of the transcription start site and 12 bases ...
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Conserved Curvature of RNA Polymerase I Core Promoter Beyond rRNA Genes: The Case of the Tritryps
... the core promoters of Tritryp rRNA gene share the conformational characteristics conserved in ...these core promoters showed that changes in curvature produced by base substitutions is sufficient to explain ...
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Genome-Wide Computational Prediction and Analysis of Core Promoter Elements across Plant Monocots and Dicots
... the core promoter elements ...the core promoter in relation to the TATA-box as well as with respect to other ...of promoter regions are distinctly different from that of the ...
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Regulation of Hepatitis B Virus Core Promoter by Transcription Factors HNF1 and HNF4 and the Viral X Protein
... the core promoter activities and to understand how it may interact with HNF1 and HNF4, we have studied the expression of precore and core RNAs from WT, M1, M4, and M5 genomic constructs, with and ...
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Requirements for Brome Mosaic Virus Subgenomic RNA Synthesis In Vivo and Replicase-Core Promoter Interactions In Vitro
... subgenomic core promoter by the BMV ...the core promoter were correlated with wild-type RNA4 levels in ...the core promoter of ...the core promoter reduced ...
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Retinoid-Induced Repression of Human Immunodeficiency Virus Type 1 Core Promoter Activity Inhibits Virus Replication
... Retinol, as well as all-trans retinoic acid and 9-cis retinoic acid, also repressed HIV-1 long terminal repeat (LTR)-directed expression up to 200-fold in transfected THP-1 monocytes. Analysis of HIV-1 LTR deletion ...
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Functional characterization of human Kindlin-2 core promoter identifies a key role of SP1 in Kindlin-2 transcriptional regulation
... the promoter of the human Kindlin-2 gene. We show that the core promoter of Kindlin-2 is a 39 base pair long GC rich fragment located -122/-83 upstream of the Kindlin-2 transcription start ...this ...
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Recognition of the Core RNA Promoter for Minus-Strand RNA Synthesis by the Replicases of Brome Mosaic Virus andCucumber Mosaic Virus
... Also, for both the BMV and CMV replicases, the presence of the entire tRNA-like structure decreased the effects of the mutations observed in the minimal SLC element. There are several precedents for upstream elements ...
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