The DNA Damage Checkpoint
DdcA antagonizes a bacterial DNA damage checkpoint
... The DNA damage checkpoint in bacteria was discovered through seminal work using ...to DNA dam- ...and DNA replication may be more complex (Goranov et ...to DNA damage by ...
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Regulation of DNA replication by the S-phase DNA damage checkpoint
... to DNA damage. This slowing was the first DNA damage checkpoint response discovered and its study led to the discovery of the central checkpoint kinase, Ataxia Telangiectasia ...
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Mutator Phenotype of Caenorhabditis elegans DNA Damage Checkpoint Mutants
... ABSTRACT DNA damage response proteins identify sites of DNA damage and signal to downstream effectors that orchestrate either apoptosis or arrest of the cell cycle and DNA ...elegans ...
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Working hard for recovery: mitotic kinases in the DNA damage checkpoint
... during checkpoint recovery Current understanding of the role of mitotic kinases in checkpoint recovery can be summarized as: 1) these ki- nases are inhibited by the DNA damage ...
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Reconstitution of a human ATR-mediated DNA damage checkpoint prespone [sic]
... the checkpoint components are incorporated into the complex, mulistep ...mediated DNA damage checkpoint response have used cell-free systems derived from Xenopus eggs, which has made ...
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Regulation of Septum Formation in Aspergillus nidulans by a DNA Damage Checkpoint Pathway
... chromosomal DNA metabolism also delay septum formation, suggesting that this is a general cellular response to the presence of sublethal DNA ...chromosomal DNA metabolism depends upon Tyr- 15 ...
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Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death
... the DNA-damaging modalities of certain chemo- and radiotherapeutic regimens, such patients face the collateral outcome of premature loss of fertility and ovarian endocrine ...oocyte DNA damage ...
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Spontaneous Chromosome Loss in Saccharomyces cerevisiae Is Suppressed by DNA Damage Checkpoint Functions
... Defective DNA replication, repair, and recombination can significantly increase the frequency of spontane- ous genomic ...Recently, DNA damage checkpoint functions that operate during the ...
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Augmented antitumor activity by olaparib plus AZD1775 in gastric cancer through disrupting DNA damage repair pathways and DNA damage checkpoint
... AZD1775-induced DNA damage and apoptosis still presented in WEE1 CRISPR-Cas9 knockout cancer cells [20], in line with reliance of AZD1775’s cytotoxicity on targeting PLK1 and WEE1 in our GC cells ...ated ...
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Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability.
... of checkpoint activation-proficient adapted cells with persistent DNA ...the DNA damage checkpoint is ac- tivated in response to telomere replication defects or telomere shortening (red ...
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The Fission Yeast Rad32(Mre11)–Rad50–Nbs1 Complex Acts Both Upstream and Downstream of Checkpoint Signaling in the S-Phase DNA Damage Checkpoint
... S-phase DNA damage checkpoint pathway: Group I contains Cds1, Mus81 and its binding partner Eme1, Group II contains Rhp51 and other recombinational regulators; and Group III contains Rqh1 and Sfr1 (W ...
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Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53
... from DNA damage during retinal ...of DNA replication errors, which might be detrimental to retinal ...the DNA damage checkpoint pathway might repair such replication errors or ...
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Regulation of Histone Deposition Proteins Asf1/Hir1 by Multiple DNA Damage Checkpoint Kinases in Saccharomyces cerevisiae
... phase/DNA damage checkpoint kinases in the budding yeast Saccharomyces ...lacking checkpoint kinase Mec1 do not display defects in telomeric gene silencing, silencing was dramatically reduced ...
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BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands
... to DNA damage checkpoint signalling, which physically couples the 9-1-1 (RAD9-HUS1-RAD1) checkpoint clamp to TOPBP1 (Cotta-Ramusino et ...
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Original Article Expression of DNA damage checkpoint 53BP1 is correlated with prognosis, cell proliferation and apoptosis in colorectal cancer
... of DNA damage checkpoint, plays an essential role in maintaining the cell genome stability, and the aberrant expression of 53BP1 was found to contribute to tumor occurrence and ...
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Spontaneous abrogation of the G2 DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients
... DNA damage checkpoints in the cell cycle may be important barriers against cancer progression in human ...inherited DNA instability disorder that is associated with bone marrow fail- ure and a strong ...
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Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint
... the DNA damage checkpoint response, has also been previously shown to form nuclear foci follow- ing irradiation (Peddibhotla et ...of DNA damage in G1 and its activating interaction ...
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Spontaneous abrogation of the G 2 DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients
... DNA damage checkpoints in the cell cycle may be important barriers against cancer progression in human ...inherited DNA instability disorder that is associated with bone marrow failure and a strong ...
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The Mitotic DNA Damage Checkpoint Proteins Rad17 and Rad24 Are Required for Repair of Double-Strand Breaks During Meiosis in Yeast
... DNA damage checkpoint genes, suggesting that the ...SPO11- checkpoint genes might also act in meiosis as in ...mitotic DNA damage checkpoint proteins in wild- and the cell ...
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The Rad9.M50 Variant of the DNA Damage Checkpoint Protein Rad9 Regulates the MAP Kinase pathway in the Response to Heat Stress
... the DNA damage checkpoint and the MAP kinase system are ...the DNA checkpoint kinase Chk2/Cds1 has been reported in large cell lymphomas (Dai, ...
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