the extracellular matrix
The Extracellular Matrix and Ca
... The extracellular matrix (ECM) consists of proteins, glycosaminoglycans and glycoproteins, that support the dynamic interactions between cells, including intercellular communication, cell attachment, cell ...
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Expression of Matrix Metalloproteinases in Naegleria fowleri and Their Role in Degradation of the Extracellular Matrix
... Matrix metalloproteinases have been found in pathogenic protozoa and implicated in degrading a wide range of connective tissue proteins primarily for the purpose of invasion through the extracellular ...
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An investigation into the role of mutant p53-dependent extracellular vesicles and their impact on the extracellular matrix
... Consistent with the trafficking of RTK influencing their signalling, mutp53 stimulation of EGFR and cMET recycling was shown to activate the Akt/PI3K and MAP kinase (MAPK) pathways respectively (Muller et al., 2013, ...
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Collagen of the extracellular matrix. Functional and structural studies.
... The cancer microenvironment has been attracting increasing attention as the realization of its importance for both disease treatment and malignant progression. Here the aim was to elucidate some of the effects and ...
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The Role of the Extracellular Matrix in Skeletal Development 1
... the extracellular matrix in skeletal development has been overlooked until the recent devel- opment of improved extraction procedures and recombi- nant DNA ...the extracellular matrix was ...
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Incorporating the extracellular matrix: new opportunities in cancer research
... the extracellular matrix (ECM), already established in normal epithelial biology, has come to the fore in the study of carcinomas ...The extracellular matrix is composed of several protein ...
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C ELLULAR adhesion to the extracellular matrix is
... To examine the ef- fect of deletion of the vinculin-binding domain on paxillin targeting, CHO.K1 fibroblasts were transfected with full- length wild-type chicken paxil[r] ...
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The extracellular matrix collagen in the coronary in-stent restenosis
... 1. Extracellular matrix reorganization is a hallmark of the in-stent restenosis basically being exhibited by excessive collagen I degradation and preserved collagen III, splitting in conditions of ...
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The Extracellular Matrix in Bronchopulmonary Dysplasia: Target and Source
... EC-SOD, extracellular superoxide dismutase 3; LOX, lysyl oxidase; LoxL1, lysyl oxidase-like 1; LoxL2, lysyl oxidase-like 2; LTBP2, latent TGF- β-binding protein 2; MMP, matrix metalloproteinase; MT1, ...
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The extracellular matrix in myocardial injury, repair, and remodeling
... structural matrix proteins increases myocardial stiffness and promotes diastolic dysfunction; in con- trast, overactive matrix-degrading pathways may promote dila- tive remodeling, causing systolic ...of ...
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The congenital clubfoot – immunohistological analysis of the extracellular matrix
... and extracellular matrix The study was approved by the ethics committee of the Free University of Berlin; after completely describing the study to the subjects, written informed consent was obtained from ...
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Degradation of the extracellular matrix is part of the pathology of ulcerative colitis
... neutrophil extracellular traps (NETs), we report novel findings, including that Extracellular Matrix (ECM) degradation and neutrophil maturation are involved in the pathology of ...
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Extracellular matrix as target for antitumor therapy
... the extracellular matrix (ECM) of tumors referring to its putative utility as therapeutic ...proteoglycans, matrix proteins, and integrins, it is rather difficult to identify a comprehensive ...
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Polycystins, focal adhesions and extracellular matrix interactions
... [10,11] . It is also perhaps surprising that polycystin-1-de ficient embryonic kidneys do not form cysts when explanted and grown in culture despite the lack of tubule flow and lack of the postulated flow sensor ...
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Imbalance in extracellular matrix degradation in urethral stricture
... MMPs are very important enzymes, due to their function in the development of healthy tissue, especially in remodeling the extracellular matrix. The main physiological function in the remodeling phase is to ...
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THE ROLE OF EXTRACELLULAR MATRIX IN CORNEAL WOUND HEALING
... Ultrasound pachymetric results revealed that LASIK performed on healthy corneas leads to the accumulation of water in the extracellular matrix. Edema appeares already intraoperatively: at photoablation and ...
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Integrated biomechanical model of cells embedded in extracellular matrix
... 2. Cell Migration Controlled migration of cells or cell processes forms the basis for the formation of various tissues and organs. For example, connections in the brain are achieved by protruding neurites guided by ...
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Bioactive extracellular matrix fragments in lung health and disease
... The extracellular matrix (ECM) is the noncellular component critical in the maintenance of organ structure and the regulation of tissue development, organ structure, and cellular ...
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Disruption of the myocardial extracellular matrix leads to cardiac dysfunction
... Received for publication August 2, 1999, and accepted in revised form August 28, 2000. MMP activity with disruption of structural collagen has been implicated in the pathophysiology of dilated cardiomyopathy. To examine ...
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Conditional Switches for Extracellular Matrix Patterning in Drosophila melanogaster
... O NE of the most basic and astonishing features of human development is the transformation of flat sheets of epithelial cells into tubes of various sizes, cell number, and branch structure, often in the absence of cell ...
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