The glucocorticoid receptor
Modelling the glucocorticoid receptor dimerisation cycle
... Chapter 1 Project motivation and outline Steroids and their cognate receptors mediate a plethora of biological processes in the human body. Glucocorticoids (GCs) regulate the immune, cardiovascular and metabolic ...
123
Unraveling the glucocorticoid receptor pathway in zebrafish
... the glucocorticoid receptor (GR) which acts as a transcription factor, regulating a wide plethora of ...synthetic glucocorticoid beclomethasone, using cell imaging as well as whole transriptome ...
121
Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis
... the glucocorticoid recpetor gene and their associations with metabolic parameters and body ...the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass ...
8
The glucocorticoid receptor and cortisol levels in pediatric septic shock
... Abstract Background: There is controversy around the prescription of adjunct corticosteroids in patients with fluid-refractory septic shock, and studies provide mixed results, showing benefit, no benefit, and harm. ...
7
Disruption of eyelid and cornea development by targeted overexpression of the glucocorticoid receptor
... 1 Department of Animal Pathology. Faculty of Veterinary Science, University of Santiago de Compostela, Lugo, Spain, 2 Project on Cell and Molecular Biology and Gene Therapy, CIEMAT. Madrid Spain, 3 AMC Cancer Research ...
6
Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance
... type receptor, but had no effect in cells expressing Val 641-mutant receptors, despite similar receptor concentrations, as indicated by Western ...641-mutant receptor was threefold lower than that of ...
8
The Glucocorticoid Receptor in Retroviral Infection
... Therefore vectors with full length LTR or truncated LTR that retain these GR responsive sequences, will behave like wild type viruses in response to GR activation whereas vectors in which they have been removed will ...
18
Antiretroviral drugs differentially modulate glucocorticoid activity via the glucocorticoid receptor in vitro
... Immortalized cells, like the U2OS cell line used in this study, unlike primary cells, avert senescence through bypassing cell cycle checkpoints, often through the expression of oncogenes (Maqsood et al., 2013). As a ...
127
A mutation of the glucocorticoid receptor in primary cortisol resistance
... 8 summarizes the sequencing of the index subject's hGR cDNA and indicates the relative cDNA and amino acid loca- tion of the mutation at hGR cDNA nucleotide 2,317. This A for G substitut[r] ...
9
Homologous down-regulation of the glucocorticoid receptor is influenced by the dimerization state of the receptor
... reduced receptor protein turnover, following treatment with ...the receptor, which is severely compromised in its ability to form receptor dimers and mediate the transactivation of GC responsive ...
276
Membrane-initiated nuclear trafficking of the glucocorticoid receptor in hypothalamic neurons
... membrane receptor, which could then relay a signal to the GR to trigger ...membrane receptor (the Dex-to-BSA ratio in the Dex-BSA conjugate was 37-to-1) was fewer than in the 1- µM Dex solution, which may ...
42
Increased Expression of the Glucocorticoid Receptor β in Infants With RSV Bronchiolitis
... human bronchial epithelial cells infec- ted with RSV and parain fl uenza virus induces production of macrophage in- fl ammatory protein-1a (MIP-1a) and IL-8. The addition of hydrocortisone at- tenuated cytokine production ...
10
Effects of prenatal and postnatal depression, and maternal stroking, at the glucocorticoid receptor gene
... income, employment, health, education and training, barriers to housing and services, living environment and crime. All mothers were given IMD ranks according to the postcode of the area where they lived and assigned to ...
5
Cell Cycle Phase Regulates Glucocorticoid Receptor Function
... The glucocorticoid receptor (GR) is a member of the nuclear hormone receptor superfamily of ligand-activated transcription ...of glucocorticoid actions was ...of glucocorticoid- induced ...
16
Potential Dissociative Glucocorticoid Receptor Activity for Protopanaxadiol and Protopanaxatriol
... Abstract: Glucocorticoids are steroid hormones that regulate inflammation, growth, metabolism, and apoptosis via their cognate receptor, the glucocorticoid receptor (GR). GR, ...
20
Glucocorticoid receptor gene polymorphism and juvenile idiopathic arthritis
... 27. van Schoor NM, Dennisont E, Lips P, Uitterlinden AG, Coopert C: Serum fasting cortisol in relation to bone, and the role of genetic variations in the glucocorticoid receptor. Clin Endocrinol (Oxf) 2007, ...
7
Glucocorticoid receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor
... the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of ...other receptor parts are also needed to create additional contacts with ...
15
Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling
... endothelial glucocorticoid receptor, act as negative regulators of ...the glucocorticoid receptor, followed by next-generation sequencing in mouse endothelial cells to investigate how the ...
16
Insight into glucocorticoid receptor signalling through interactome model analysis
... Abstract Glucocorticoid hormones (GCs) are used to treat a variety of diseases because of their potent anti-inflammatory effect and their ability to induce apoptosis in lymphoid malignan- cies through the ...
27
Insight into glucocorticoid receptor signalling through interactome model analysis
... simulate glucocorticoid receptor control of both directly-regulated and indirectly-regulated genes ...the glucocorticoid receptor has not been ...
110