The HLA
Varicella-Zoster Virus-Derived Major Histocompatibility Complex Class I-Restricted Peptide Affinity Is a Determining Factor in the HLA Risk Profile for the Development of Postherpetic Neuralgia
... specific HLA alleles and PHN stems from the affinity at which the VZV- derived peptides are being presented by the MHC I molecules to CD8 ⫹ T ...ferent HLA groups is their specificity and affinity for ...
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HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing
... [32,33]. HLA class I heterodimers are constituted by an alpha-heavy chain, encoded by HLA-A, B or C loci, and by a small beta2- microglobulin molecule whose gene maps on chromosome ...15. HLA class ...
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Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes
... of HLA mutation across tumors and showed that such mutations occurred preferentially in tumors with high mutation burden and under strong pressure by the immune system as evi- denced by high levels of CD8+ T cell ...
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Contrasting roles of interallelic recombination at the HLA-A and HLA-B loci.
... Allelic phylogenies: Phylogenetic trees were con- structed for A (Figure 3) and B (Figure 4) locus alleles of human and chimpanzee by the neighborjoining method (S[r] ...
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The course of clinically suspect arthralgia and early rheumatoid arthritis : clinical features, imaging and genetics
... the HLA-DRB1 region in which the same position can encode for both predisposing and protective variants adds another level of ...at HLA-DRB1 position 11 were truly predisposing to more severe ...
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Stability and Expression Levels of HLA-C on the Cell Membrane Modulate HIV-1 Infectivity
... the HLA-C*06 (stable) or the HLA-C*07 (unstable) ...in HLA-C*06-expressing cells than in HLA-C*07- expressing cells in four independently replicated experiments ...that HLA-C*06 has a ...
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A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice
... various HLA class I or class II molecules (38). HLA-B27 is strongly associated with anterior uveitis that accompanies ankylosing ...spondylitis. HLA-A29 confers an in- creased risk of birdshot ...
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HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load
... of HLA class I alleles have been associated with slow HIV disease progression, but the relative contribution of the presenting allele versus the restricted epitopes towards this relative protection remains ...the ...
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Unusually high frequency of Epstein-Barr virus genetic variants in Papua New Guinea that can escape cytotoxic T-cell recognition: implications for virus evolution.
... the HLA. It has recently been proposed that the distribution of HLA frequencies and the specific CTL response may influence the long-term evolution of Epstein-Barr virus (EBV) by selecting variants which ...
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HLA Class I-Mediated HIV-1 Control in Vietnamese Infected with HIV-1 Subtype A/E
... on HLA association with disease progression af- ter HIV-1 infection have been performed on cohorts infected with HIV-1 subtypes B and C, whereas few such population-based studies have been reported for cohorts ...
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HLA E gene polymorphism associates with ankylosing spondylitis in Sardinia
... the HLA-E-NKG2A pathway is likely to play a role in celiac disease ...a HLA-E neighboring gene rather than HLA-E itself, could be the real factor contributing to the ...the HLA-E molecules ...
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Association of HLA class I and II genes with cutaneous leishmaniasis: a case control study from Sri Lanka and a systematic review
... the HLA poly- morphism in cases and controls ...assessed HLA poly- morphism in visceral leishmaniasis including a large scale multicentre study in Brazil and India [45], but not for cutaneous ...no ...
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Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants
... If HLA class I molecules are shared between partners, the recipient’s ability to mount a response against infection will be impeded, particularly if es- cape has occurred through change at an HLA anchor ...
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Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV resistant prostitutes in Nairobi
... II HLA alleles are associated with reduced risk of HIV-1 infection (MacDonald, ...with HLA-A*6802, A*0202, and ...I HLA molecules are restricting elements for particularly efficient HIV-specific CTL ...
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HLA molecules and nasal carriage of Staphylococcus aureus isolated from dialysis and kidney transplant patients at a hospital in Southern Brazil
... the HLA system in pathogenesis has been studied in several diseases, such as skin diseases [16-18], tuberculosis [19,20], psychiatric illnesses [21,22], as well as hearing [23,24], sight [25,26] and kidney [27] ...
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Original Article Human leukocyte antigen-DRB1*1501 and DQB1*0602 alleles are cervical cancer protective factors among Uighur and Han people in Xinjiang, China
... including HLA-DRB1*1501 and DQB1*0602, HR-HPV infection among Chinese Ui- ghur and Han ...and HLA-DRB1*1501 and DQB1*0602 alleles were performed using PCR-SSP ...all). HLA-DRB1*1501 (OR = 0.305; 95% ...
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Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals
... diverse HLA alleles among humans complicate virus-specific cellular immunity research, and elucidation of cross-HLA allele T cell responses to influenza virus specificity requires further detailed ...the ...
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Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition
... ied HLA polymorphism on peptide conformation/dynamics has implications in graft-versus-host ...between HLA-B*3501 and ...of HLA-B*4402 and HLA- B*4403, two allomorphs that diff er by just one ...
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HLA gene amplification and hybridization analysis of polymorphism HLA matching for bone marrow transplantation of a patient with HLA deficient severe combined immunodeficiency syndrome
... of HLA compatibility between recipient and ...of HLA sometimes makes it difficult, if not impossible, to determine the patient's HLA type by standard serological and cellular ...resolution HLA ...
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Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses
... the HLA-C–inhibited NK cell subset in HLA-C1 homozygous subjects was larger and responded more rapidly in IFN-γ secretion and CD107a degranulation assays than its counterpart in HLA-C2 homozygous ...
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