The human ubiquitin system
The Ubiquitin-Proteasome System Is Necessary for Efficient Replication of Human Astrovirus
... free ubiquitin, which in turn may affect the de novo ubiquitination of ...of ubiquitin available for ubiquitination, which is required for virus budding ...the ubiquitin siRNA on virus replication ...
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Targeting the ubiquitin system in glioblastoma
... ring system found in thalidomide and its derivatives was also utilized for DDB1 –CRBN recruitment in a PROTAC design for the degradation of bromodomain and extra- terminal (BET) proteins ( 403 ...a human ...
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Targeting the Ubiquitin Proteasome System in Cancer
... several human diseases such as neurodegenerative disease, inflam- mation, bacterial and viral infection and most importantly, in ...of ubiquitin linkages formed/cleaved with the help of a cascade of enzymes ...
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TRIB2 and the ubiquitin proteasome system in cancer
... Tribbles homolog 2 (TRIB2) is a pseudokinase that functions as a molecular adaptor mediating degradation and changes to signalling cascades [1] . TRIB2 is also shown to be a potent oncogene in a variety of malignancies, ...
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Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin conjugating enzymes, ubiquitin activating enzymes, and ubiquitin like proteins
... Given the central role of ubiquitylation in the degradation of such key regulators as mitotic and meiotic cyclins, p53, IkB, many transcription factors, hormone receptors and other proteins, there is widespread interest ...
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Role of the ubiquitin system in regulating ion transport
... by ubiquitin is that of ENaC regulation by Nedd4- ...(except human, zebrafish and Drosophila Nedd4-1), appears to provide higher affinity interactions to PY motifs [80, 101], but both WW3 and WW4 of Nedd4-2 ...
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Human Cytomegalovirus UL76 Elicits Novel Aggresome Formation via Interaction with S5a of the Ubiquitin Proteasome System
... Department of Microbiology, Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China a ; Department of Cell Biology and Anatomy, National Cheng Kung University, ...
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The Roles of Ubiquitin-Binding Protein Shuttles in the Degradative Fate of Ubiquitinated Proteins in the Ubiquitin-Proteasome System and Autophagy.
... Keywords: ubiquitin-proteasome system; selective autophagy; proteostasis; protein quality control; ubiquitination ...in human cells require removal due to their improper folding, despite the presence ...
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Degradation or Maintenance: Actions of the Ubiquitin System on Eukaryotic Chromatin
... the ubiquitin system in different organisms are often highly conserved, and in many cases the human homologs are able to complement the phenotypes of the cor- responding yeast ...of ubiquitin, ...
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The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma
... a transcription factor. Proteasome inhibitors thus influ- ence both gene transcription and protein degradation. The proteasome inhibitor bortezomib, approved by the FDA for treatment of multiple myeloma and mantle cell ...
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The ubiquitin-proteasome system in glioma cell cycle control
... Last but not least, the induction of G0/G1 or G2/M cell cycle arrest and/or apoptosis, whenever indicated as a response to various stressors, could not be ensured without the critical involvement of p53, whose levels and ...
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Emerging therapies targeting the ubiquitin proteasome system in cancer
... The overall impact of these findings is quite compelling, and they have three important implications. First, routine analysis of CRBN levels in patients with MM may soon lead to a personalized approach to the selection ...
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Degradation or Maintenance: Actions of the Ubiquitin System on Eukaryotic Chromatin
... the ubiquitin system in different organisms are often highly conserved, and in many cases the human homologs are able to complement the phenotypes of the cor- responding yeast ...of ubiquitin, ...
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Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy
... homeostasis (proteostasis) [2], including the UPS (Figure 1). Genome sequencing has revealed that cancer genomes are typically littered with dozens to hundreds of point mutations in protein coding sequences [3]. Many of ...
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The expression of the ubiquitin ligase subunit Cks1 in human breast cancer
... CO 2 . Under these conditions, the proliferation rate of all cell lines was similar (21 to 22 hours doubling time). Immunoblotting Samples containing 30 µ g of protein were resolved by electro- phoresis on a 12.5% ...
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Dissection of the HIV Vif Interaction with Human E3 Ubiquitin Ligase
... the human E3 ligase com- ponents EloBC and Cul5 (Table ...the human E3 ubiquitin ligase: the Vif BC box interacts with EloBC ...the human E3 ubiquitin ligase machinery to evade the ...
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Regulation of Human 69-kDa Choline Acetyltransferase Protein Stability and Function by Molecular Chaperones and the Ubiquitin-Proteasome System
... As is common for cell-based studies, transient transfections were used throughout my experiments as I required straightforward, routine, effective, and consistent heterologous expression of multiple proteins of interest ...
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Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome
... in human DS cells point to the presence of abnormalities of extracellular matrix, of mitochondrial function and other metabolic pathways, including purine metabolism, in fetal specimens [5,11,13], and changes in ...
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Ubiquitin ligase A20 regulates p53 protein in human colon epithelial cells
... Total RNA was extracted from the collected cancer tis- sue and polyp epithelium using Trizol reagent according to the manufacturer’s instructions. Two micrograms of RNA were reversely transcribed in a 20 μl reaction ...
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Hepatitis E Virus Replication Requires an Active Ubiquitin-Proteasome System
... a human hepatocellular car- cinoma cell line, Huh7-S10-3, which is permissive for HEV repli- cation, was used, and the cells were maintained in Dulbecco’s modified Eagle’s medium supplemented with 10% fetal bovine ...
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