The Kid and I

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INPP4B: the New Kid on the PI3K Block

INPP4B: the New Kid on the PI3K Block

INPP4B is one of many enzymes maintaining tight homeostasis of phosphoinositides in the cell. Phosphoinositides are produced by a large number of phosphatidylinositol kinases and dephosphorylated by lipid phosphatases with specific activities for phosphates at different positions of the inositol ring. INPP4B contains an N-terminal C2-lipid binding domain, internal NHR2 (Nervy Homology 2 domain), and a C-terminal phosphatase domain (Figure 1A). Human and mouse INPP4B C2 lipid binding domains exhibit over 91% identity. It has been shown that mouse INPP4B C2 domain preferentially binds phosphatidic acid and phosphatidylinositol 3,4,5-trisphosphate PI(3,4,5)P3 [1]. The NHR2 domain is a hydrophobic repeat that has been shown to mediate oligomerization and protein-protein interaction [2-4]. Although a role for this domain has yet to be determined it may mediate some interactions of INPP4B with other proteins. The C-terminal lipid phosphatase domain contains a CKSAKDRT (aa 842-849) motif conserved between type I and type II phosphatases that contains the catalytic active site (C(X) 5 R) of Mg 2+

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भारतीय परंपरा में शिक्षा व्यवस्था

भारतीय परंपरा में शिक्षा व्यवस्था

izkphu Hkkjrh; ijEijk esa v/;kiu O;oLFkk vR;Ur leqUur jgh gS A ml dkykof/k esa v/;kid dk dk;Z lwpuk vkSj Kku esa Li’V Hksn djrs gq, fo|kfFkZ;ksa dks Kku iznku djuk gksrk Fkk vkSj Kku dk ykHk lekt dks Hkh ;Fkksfpr ek=k esa fey lds ;g fu/kkZfjr djuk Hkh mudk mÌs”; Fkk A bl gsrq v/;kid Lo;a dks Jo.k] euu] fufn/;klu] lE;d n”kZu] lE;d Kku] lE;d pfj=] vk’Vkafxd ekxZ] v’Vkax ;ksx rFkk lk/ku prq’V; vkfn ds }kjk vkyksfdr djrk Fkk ,oa rnuq#i fo|kfFkZ;ksa lfgr lEiw.kZ lekt dks Hkh izdkf”kr djrk Fkk A rRdkyhu lekt esa lEiw.kZ f”k{k.k O;oLFkk dk mRrjnkf;Ro lkewfgd Fkk] ftldk iw.kZ fuoZgu lekt djrk Fkk A mDrdkyhu ifjfLFkfr esa v/;kid ds leLr ewyHkwr vko”;drkvksa dh vkiwfrZ djuk lekt dh ftEesnkjh Fkh] QyLo#i v/;kid iw.kZdkfyd #i esa vius lEiw.kZ nkf;Roksa dk fuoZgu u dsoy fo|kfFkZ;ksa ds fy, cfYd vko”;drkuqlkj lekt ds fy, Hkh djus gsrq lnSo rRij vkSj rS;kj jgrk Fkk] og Hkh viuh vko”;drkvksa dh fpark fd, fcuk vkSj ,slh fLFkfr esa v/;kid dk lEeku cgqr ÅWapk ,oa vkn”kZijd Fkk A

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The Safe Environment for Every Kid Model: Impact on Pediatric Primary Care Professionals

The Safe Environment for Every Kid Model: Impact on Pediatric Primary Care Professionals

quite fussy, and his mom seems a bit irritated with him. She says ‘He’s not easy like my other two.’ You suggest how she could care for him and she re- sponds, ‘We’ll be fine!’ ” This was fol- lowed by statements such as “It’s under- standable that she’s irritated; I would not interfere.” For each statement, HPs re- sponded on a 5-point Likert scale (strongly agree to strongly disagree). HPQ items were grouped conceptually into 4 topical scales (eg, substance abuse) that covered their attitudes, knowledge, comfort, competence, and practice regarding each problem. Cronbach’s 16 ␣ values were adequate

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'The kid most likely’: naming, brutality and silence within and beyond school settings

'The kid most likely’: naming, brutality and silence within and beyond school settings

members, is surely the crucial way forward. I would argue then for an insistent and collective speaking into those spaces of naming and silence that—be they located in the micro practices of schools and classrooms, or performed on the broader stage of national and global politics—produce the kinds of conditions of impossibility that claim the learning, the optimism, and the possible futures of far too many young people. As we endeavour to analyse discursive complicities not for the purposes of apportioning blame, but in order to "obtain a means of discovering what has to be done" (Certeau, 1997, p. 30), perhaps we might open up new possibilities for 'the kid most likely' to make it through, to grow up, to join in, to answer back, to speak a new language in which the brutality of naming and silence has no place.

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‘Everyone Knows Me as the Weird Kid’: Being Bisexual, Genderfluid and Fifteen

‘Everyone Knows Me as the Weird Kid’: Being Bisexual, Genderfluid and Fifteen

Max: One is I always have a pack of bobby pins, which I wear in my hair. When people questioned me about it I never said anything apart from, ‘They keep my hair out my eyes’. But now it’s gone to always having a hair brush on me because I’m growing my hair. Having hair this short and wearing a dress doesn’t work! Just today I started carrying a mirror around on me too coz that [messes up his hair] is annoying! I also ran a lesson about stuff. In my RE 2 class we covered Christian views on being gay and same-sex attraction – which was a

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Assessment of the KID Procedure on a Mo–oxo Complex, an Open–Shell System

Assessment of the KID Procedure on a Mo–oxo Complex, an Open–Shell System

The MGGA set of DF also shows similar deviations from the Koopmans’ theorem since that 2.182 < J ( HL ) < 2.330 and the average values of h J ( HL )i (1) = 2.260 and h J ( HL )i (2) = 2.260. Besides we observe that the increase of the basis set size do not improve the performance of the Koopmans’ theorem. The 6-311+G(d,p) basis set for non metal atoms only favor the J ( I ) when using MN12-L, but in general the best DF in the MGGA set is MN12-L along when using the 6-31+G(d,p) basis set for non metal atoms. The HGGA set of DF shows us a more significant improvement because 1.428 < J ( HL ) < 1.914 and the average values of h J ( HL )i (1) = 1.647 and h J ( HL )i (2) = 1.645, being the PBE0 the best DF with the 6-311+G(d,p) basis set for non metal atoms.The HMGGA set of DF presents a better performance in the use of the Koopmans’ theorem when comparing with the MGGA set because 0.395 < J ( HL ) < 1.888 and h J ( HL )i (1) = 1.105 and h J ( HL )i (2) = 0.990, where M06-2X is the best DF along with the 6-311+G(d,p) basis set.

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Creating Exhibits for Small History Museums on a Limited Budget

Creating Exhibits for Small History Museums on a Limited Budget

communicating between various teams across the organization, all who played a different role in the program. Since this was the first time for UNICEF Kid Power in several cities, there was a lot of learning to be done on how to streamline the program activation among all regions. The scale of the program also meant that all marketing and promotion for the program had to be consistent across every region. Additionally, there was a certain amount of funding needed in order for the program to take place in the Bay Area. I collaborated with colleagues to explore potential funders, edit grant proposals, and report on program successes to the funders. This consisted of researching local foundations and influencers both online and in our current donor database, as well as making sure proposals and program reports articulated the program and its impact in a strong manner. It was important to not only find the right funders for the program, but to build a strong relationship with them in order to sustain their financial support.

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Children

Children

Kids keep pestering Granny. Tiny missy Lulu insists, “You MUST come here live with me, Gumma!” “I have a work to do here, dear.” “You can find work here, Gumma! I want YOU!” and their phone lingered on. That whole night, Granny could not sleep over her very own Lulu so BIG so tiny, and so tender so insistent, ever so world-precious indeed. Granny’s days are kept so fresh so alive by her BIG tiny Lulu so powerful over her. Our days keep following these precious kids as Lulu. Kids literally live every single day of ours , keeping all our days kid-fresh and jumping alive! We are all won over!

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River Road: Journeys through ecology

River Road: Journeys through ecology

As a kid growing up along the river and even swimming in the river I also heard stories about enchanted logs that were taniwha in their own way, seen to be floating up against the current of the river and heading up stream, and being told that if you see something like that you have to get out of the water. They’re ancestral spiritual guardians that show themselves at different points of time when something major or significant is happening. If a chief or kaumatua had died often the taniwha would appear, and sometimes it would be in the form of a log going up river against the current. I haven’t seen it happen but my grandparents saw something like that just before the outbreak of the influenza epidemic. They were washing their clothes on the banks of the river, downstream from Türangawaewae. There was a log on the river bank and they just had this bad feeling about this log. They stayed away; they just didn’t want to go near it. When they came back about an hour later, the log was gone. Next thing deaths were happening; about two or three days later, the outbreak of the influenza epidemic. They didn’t get sick, that’s the strange part about it. But other families within the village at Te Köpae, just near Ngäruawähia, actually perished.

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Characteristics of patients with body mass index recorded within the Kent Integrated Dataset (KID)

Characteristics of patients with body mass index recorded within the Kent Integrated Dataset (KID)

The Kent Integrated Dataset was set up in 2014 as part of the NHS England funded programme Long Term Conditions Year of Care. Since then, its use has been extended to broader range of public health questions providing insight into population health and system-level use of services. There is a strong legal basis for sharing data due to a number of powers and duties being placed on Clinical Commissioning Groups and Local Authorities by the Health and Social Care Act 2012—especially in the context of public health surveillance. These powers have also been underlined within the General Data Protection Regulation as set out in Article 9 (2)(i), which allows the processing of ‘special category personal data’. Further- more, the Health Service (Control of Patient Informa- tion) Regulations 2002 Regulation 3 also sets out a remit for risks to public health.

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Psychometric evaluation and wording effects on the Chinese version of the parent-proxy Kid-KINDL

Psychometric evaluation and wording effects on the Chinese version of the parent-proxy Kid-KINDL

Construct validity as well as the wording effects were evaluated and supported by our six CFA models. Model 1, which considered no wording effects, showed that all fit indices were unacceptable. The fit indices of Models 4 to 6, which considered wording effects, were substan- tially better than those of Model 1. Specifically, the con- struct of parent-rated Kid-KINDL was established when accounting for wording effects, and indirectly supported that wording effects exist. The performance of these four models in the present study is comparable to the child- reported Kid-KINDL study [10], which also demon- strated the best model fit in Models 4 and 6. Therefore, we have extended the results of wording effects to the parent-proxy Kid-KINDL. Nevertheless, our finding which showed that the method effects of item wording were artifacts (i.e., one kind of error caused by response style) agreed with those of other studies on the Rosen- berg self-esteem scale [31–33]. Although the artifacts might be invariant over time [33, 34], we propose that rewording these sentences so that they express clear concepts will solve this problem. The effect of artifacts on the parent-proxy Kid-KINDL should be reduced in the future refinement of the questionnaire.

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“PROBIOTIC POTENTIAL OF COMMERCIAL AVAILABLE PROBIOTIC PREPARATIONS IN PREVENTION OF ENTERIC BACTERIAL INFECTIONS: AN IN-VITRO STUDY” by S.A. Bhutada*, S. B. Dahikar and D.H. Tambekar, India.

“PROBIOTIC POTENTIAL OF COMMERCIAL AVAILABLE PROBIOTIC PREPARATIONS IN PREVENTION OF ENTERIC BACTERIAL INFECTIONS: AN IN-VITRO STUDY” by S.A. Bhutada*, S. B. Dahikar and D.H. Tambekar, India.

Antibacterial activity and characterization of bacteriocin: Antibacterial activity (fig.2) of bacteriocin produced by commercial probiotic preparations Pre-Pro kid, Sporlac powder, LactoBacil plus, P-Biotics kid, Gastroline containing probiotics (Score 20-24). Bacteriocins of all the selected commercial probiotic preparations were stable at 90 0 C and acidic to neutral pH i.e. (3 to 7) except P- Biotics kid was stable up to 100 0 C. Bacteriocins of standard probiotic strains were stable up to 100 0 C and pH 3 to 7.

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Connexin26 hemichannels with a mutation that causes KID syndrome in humans lack sensitivity to CO2

Connexin26 hemichannels with a mutation that causes KID syndrome in humans lack sensitivity to CO2

and a second died from breathing failure (Sbidian et al., 2010). Nevertheless, without detailed record- ings of cardiorespiratory activity, it is not possible to know whether these patients experienced inade- quate central respiratory drive. For other mutations linked to KID syndrome there are no reports of abnormal breathing in the literature.

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Arterial stiffness is a predictor for acute kidney injury following coronary artery bypass graft surgery

Arterial stiffness is a predictor for acute kidney injury following coronary artery bypass graft surgery

CKD: Chronic kidney disease; CSA-AKI: Cardiac surgery-associated acute kid- ney injury; eGFR: Estimated glomerular filtration rate; ESRF: End stage renal failure; HR: Heart rate; IDMS: Isotope dilution mass spectrometry; KCH: King ’ s College Hospital; KDIGO: Kidney Disease Improving Global Outcomes; LVH: Left ventricular hypertrophy; NCEPOD: National Confidential Enquiry into Patient Outcomes and Death; NIHR/HEE: National Institute for Health Research/Health Education England; PWV: Pulse Wave Velocity; RIFLE: Risk, Injury, Failure; Loss, End-Stage Renal Disease

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Incidence of Fractures Attributable to Abuse in Young Hospitalized Children: Results From Analysis of a United States Database

Incidence of Fractures Attributable to Abuse in Young Hospitalized Children: Results From Analysis of a United States Database

This study provides the first national US estimates of the incidence of hospitalization with fractures attributable to abuse among young children. We found that, in 3 dif- ferent years (1997, 2000, and 2003), the proportion of fractures attributable to abuse was 11.9% to 12.1%, based on the KID. In 2003, the proportion of fractures attributable to abuse in children ⬍ 12 months of age was 24.9%; this proportion decreased to 2.9% in children 24 to 35 months of age. The overall incidence of abusive fractures was 15.3 cases per 100 000 for children 0 to 36 months of age and 36.1 cases per 100 000 for children ⬍ 12 months of age. In the youngest age group, ⬎ 50% of fractures of the ribs, radius/ulna, and tibia/fibula were attributable to abuse. In contrast, of the 3363 cases of skull fractures in this age group, only 17.1% were cate- gorized as abuse. For children 24 to 35 months of age, the most commonly fractured bones were the humerus and femur, and the likelihood of abuse was extremely low.

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Copper metabolism in goat–kid relationship at supplementation of inorganic and organic forms of copper 

Copper metabolism in goat–kid relationship at supplementation of inorganic and organic forms of copper 

AbstrACt: The aim of the experiment was to compare the effect of inorganic and organic forms of copper (Cu) supplementation on Cu status of goats and their kids, colostrum and milk composition and quality, and on the Cu concentrations in amniotic fluids and fetal membranes. The experiment involved 22 clinically healthy preg- nant goats with similar mean Cu concentration in blood serum. Goats were divided into 3 groups: E1, E2, and C. Basal feed ration differed only in Cu form and concentration in a grain mixture. The goats of experimental groups E1 and E2 received the supplement of Cu sulfate and Cu chelate, respectively. Control group C was without Cu supplementation. Blood samples from goats and kids were collected on the day of parturition (day 0; in kids before colostrum intake) and on days 2, 7, and 21 postpartum. On the same days the kids were weighed. Colostrum or milk samples were collected on days 0, 5, and 30. During delivery, also samples of amniotic fluids and fetal membranes were collected. Both forms of Cu supplementation resulted in higher average concentration of Cu (compared to control group) in blood serum of goats (19.5 ± 1.7 and 18.5 ± 2.5 vs. 15.2 ± 4.4 µmol/l, respectively) and blood serum of kids (6.7 ± 0.8 and 6.0 ± 0.5 vs. 6.0 ± 1.0 µmol/l, respectively). Significant differences in Cu serum concentration on the day of parturition in goats were observed in group E1 compared to control (P < 0.05) and also in kids of group E1 compared to group E2 and control (P < 0.05). The Cu concentration in the blood of kids on the day of parturition was significantly (P < 0.01) lower compared to that in maternal blood. Percentages of Cu concentration in the blood of kids in groups E1, E2, and C were 34, 33, and 39% of that in maternal blood. The results of Cu concentration in blood serum of goats on days 2, 7, and 21 were without significant differences between groups. Significantly higher Cu serum concentrations (P < 0.05) were observed in kids on day 2 in group E1 compared to control group and also on day 21 in group E1 compared to group E2. Colostrum Cu concentration was significantly (P < 0.05) higher in group E1 (10.6 ± 3.3 µmol/l) compared to group E2 (7.1 ± 1.5 µmol/l). There were no significant differences observed in Cu concentration in amniotic fluids and fetal membranes. The kids on both forms of Cu supplementation (on day 0 in group E1 and on days 2, 7, and 21 in group E2) had significantly (P < 0.05) higher average weight than the kids from control group. Our results are suggesting that the inorganic form of Cu (copper sulfate) is more efficient than organic (copper chelate) in influencing the Cu metabolism in goat–kid relationship and that Cu supplementing has a positive effect on the weight of kids.

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Effects of goat social rank on kid gender

Effects of goat social rank on kid gender

Effects of sire on kid gender approached signi- ficance (P = 0.094) (Table 2). Even if a buck has a low probability of siring the male progeny, the age of the sire may change the progeny gender. The data record containing the progeny of sire “9887”, which was always older than 3.5 years, in the years was used. The sires in the other groups were younger than 3.5 years. Jacobsen et al. (1999) reported that the effects of father’s age and number of children per plural birth were significant in humans and the ratio of males decreased as father’s age increased. They reported that the male ratio decreased with the paternal age from 51.6 in fathers <25 years to 51.0 in fathers aged ≥40 years. Gorecki (2003) re- ported that different sires with different testostero- ne levels could have different gender ratios in their progeny. In this study, older sires had more female progeny, which could be due to lower testosterone levels compared to younger sires (Harman et al., 1978).

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- excretion of diff erent hormones and organic substances. Kidney diseases are as complicated as the organ it- self. They can be divided into developmental anoma- lies and inherited diseases or acquired diseases. With respect to the further course of illness they can be divided into acute and chronic kidney diseases. In the practice every dentist is placed into a situation to treat patients with a grossly impaired renal function. Familiarity with the nature of the disease in question and possible complications that may develop in these patients is indispensable prior to any dental treatment, particularly of invasive nature as it is the case in oral surgical interventions (). Also, we should note that dental infections may cause acute glumerulonephri- tis or progression of this disease into chronic failure. Experiments have shown that pyelitis or pyelonephritis can be caused by a bacterial infection which is inocu- lated into the kidney from any chronic dental infection. Experimental evidence support a connection between kidney calucus and oral infection. Th e aim of this article is to present current dental practice in patients with kidney diseases. Th is implies the dental treatment and preparations of patients who suff er from chronic kid- ney disease, nephrotic syndrome but also the patients who use dialysis and those with kidney transplants.

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Comparison of organic and inorganic forms of selenium in the mother and kid relationship in goats

Comparison of organic and inorganic forms of selenium in the mother and kid relationship in goats

Supplementing selenium during pregnancy can affect not only the mother’s organism but can also supply the organism of the newborn kid. In se- lenium-supplemented mothers the selenium con- centration increased in the blood, colostrum, and milk; it was also proved that the selenium level increased in the allantoic sac (Hefnawy et al., 2008). Selenium penetrates the placenta and the mam- mary barrier and the transfer via the placenta is more efficient than the transfer of selenium into the calf’s organism via milk uptake (Enjalbert et al., 1999). Placental transfer is bi-directional and this may affect the net retention of selenium in mater- nal, foetal, and neonatal tissues. It is still elusive whether selenium rapidly passes the placenta or is actually concentrated in placental tissues. It seems that transport process may be a more complex ac- tion than a simple passive transfer mechanism (Pappas et al., 2008).

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