The mammalian TOR pathway
TOR gene, for example, mTOR (mammalian
... The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates cell growth and metabolism in response to diverse external ...mTOR-mediated pathway has been shown to promote ...
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New insights into the "in vivo" and "in vitro" functions of mammalian TOR complex 2
... Upregulation of the mTOR signaling pathway is a common event in many tumors. However, most cancer studies addressed the role of mTOR dysregulation using the drug rapamycin, which specifically inhibits mTOR that ...
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An emerging role for TOR signaling in mammalian tissue and stem cell physiology
... of TOR signaling To date, the majority of studies on the signaling events upstream of mTOR have been focused on TORC1 rather than on ...of TOR signaling and into the mechanisms by which the TOR ...
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The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth
... FIGURE 1 | Schematic indicating processes affecting cell size and growth downstream of mammalian TORC complexes. Black arrows indicate well-established relationships between TORC1 and TORC2 with temporal and ...
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The TOR pathway interacts with the insulin signaling pathway to regulate C elegans larval development, metabolism and life span
... factors. Mammalian TOR controls the translation machinery via activation of the p70 S6K protein kinase and via inhibition of the translation inhibitor 4E-BP (Schmelzle and Hall, ...
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The effector AWR5 from the plant pathogen Ralstonia solanacearum is an inhibitor of the TOR signalling pathway
... Heterologous production in Saccharomyces cerevisiae has offered promising and effective strategies to characterize bacterial T3Es 8 . Seminal work with YopE showed that this T3E caused specific growth inhibi- tion and ...
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The effector AWR5 from the plant pathogen Ralstonia solanacearum is an inhibitor of the TOR signalling pathway
... Heterologous production in Saccharomyces cerevisiae has offered promising and effective strategies to characterize bacterial T3Es 8 . Seminal work with YopE showed that this T3E caused specific growth inhibi- tion and ...
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Spargel/dPGC-1 Is a New Downstream Effector in the Insulin–TOR Signaling Pathway in Drosophila
... or TOR results in developmental growth defects due to low ATP ...its mammalian counterpart, Spargel/dPGC-1 is recognized for its role in energy metabolism through mitochondrial ...this pathway ...
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The Human Gut Microbial Metabolome Modulates Fungal Growth via the TOR Signaling Pathway
... the mammalian gut contains a tremendous number of diverse mole- cules with critical biological functions (17, ...albicans TOR pathway, a central signaling circuit that controls cellular growth in ...
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Role for the Phosphatidylinositol 3-Kinase-Akt-TOR Pathway during Sindbis Virus Replication in Arthropods
... (PI3K)-Akt-TOR pathway is a signaling pathway with which viruses interact to manipulate cellular ...this pathway can enhance translation and inhibit apoptosis, potentially promoting viral ...
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Transcriptional Profiling of Patient Isolates Identifies a Novel TOR/Starvation Regulatory Pathway in Cryptococcal Virulence
... and pathway analysis demonstrated a role for STL1 in mammalian pathogenesis and revealed that STL1 ex- pression is regulated by a novel multigene regulatory mechanism involving the CAC2 subunit of the ...
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Rhb1 Regulates the Expression of Secreted Aspartic Protease 2 through the TOR Signaling Pathway in Candida albicans
... to TOR signaling in ...of mammalian Tor (mTOR) ki- nases ...of mammalian TORC1 (mTORC1) to trigger downstream signaling cascades ...in TOR signaling in ...
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HIF hydroxylation and the mammalian oxygen sensing pathway
... Future questions The study of the interaction of pVHL with HIF has led to new insights into the mammalian oxygen-sensing pathway and has demonstrated a heretofore unappre- ciated role for enzymatic protein ...
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The Atg1 Tor pathway regulates yolk catabolism in Drosophila embryos
... of Tor. DISCUSSION Our study revealed new aspects of Tor/Atg1 biology, as well as providing progress on how yolk catabolism is ...dramatic Tor knockdown phenotype, with profound disorganization of ...
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MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.
... suppressor pathway regulates organ size and tissue homoeostasis in response to diverse sig- naling ...the pathway consists of a short kinase cascade: MST1 and MST2 phosphorylate and ac- tivate LATS1 and ...
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Drosophila p53 related protein kinase is required for PI3K/TOR pathway dependent growth
... PI3K/TOR pathway. This pathway has been shown to be fundamental for animal growth, transducing the hormonal and nutritional status into the protein translation ...PI3K/TOR pathway, ...
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Shaping the mammalian auditory sensory organ by the planar cell polarity pathway
... the mammalian PCP pathway concurrently regulates the establishment of PCP, manifested with uniform oriented stereocilia of hair cells and CE in the cochlea during terminal ...
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Requirement and Function of Hippo Pathway Signaling in the Mammalian Gastrointestinal Tract: A Dissertation
... When I first began this work, part of the experimental rationale was to dissect the exact relationship between YAP/TAZ and Wnt pathway signaling in the intestine. Wnt/β- catenin signaling is required to maintain ...
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Mammalian upstream Hippo signalling pathway proteins activate core pathway kinases and functionally antagonize oncogenic YAP
... regard are only based on overexpression, and there is no evidence that CTGF levels correlate with the clinical parameters here at stake. A particularly exciting research avenue is the crosstalk with other signals feeding ...
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Genomic Identification of the TOR Signaling Pathway as a Target of the Plant Alkaloid Antofine in the Phytopathogen Fusarium graminearum
... IMPORTANCE Fusarium head blight caused by the fungal pathogen Fusarium graminearum is a devastating disease of cereal crops worldwide, with limited effec- tive chemical treatments available. Here we show that the natural ...
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