The maximal electroshock seizure test
Comparison of the anticonvulsant potency of various diuretic drugs in the maximal electroshock-induced seizure threshold test in mice
... Background. The coexistence of seizures and arterial hypertension requires an adequate and efficacious treatment involving both protection from seizures and reduction of high arterial blood pressure. Accumulat- ing ...
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Anti-Seizure Activity of Tabernaemontana Divaricata against Maximal Electroshock and Pentylene Tetrazole Induced Convulsions in Animals
... Statistical Analysis: The values are expressed as Mean ± Standard Error of Mean. P< 0.05 was considered statistically significant. Data obtained was analyzed by One-way ANOVA with Dunnett’s multiple comparison post ...
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EVALUATION OF ANTI-SEIZURE ACTIVITY OF THE THOTTEA SILIQUOSA EXTRACT ON MAXIMAL ELECTROSHOCK AND PENTYLENETETRAZOLE INDUCED SEIZURES IN ALBINO WISTAR RATS
... MES test is the most frequently used as an animal model for identification of anticonvulsant activity of drugs for the generalized tonic-clonic seizures "grand mal" (Loscher W and Schmidt D, 1988; Oliveira ...
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IN VITRO STUDY OF ANTICONVULSANT ACTIVITY ON THE FRUITS EXTRACTS OF COCCINIA INDICA (WIGHT &ARN ) INDUCED MAXIMAL ELECTROSHOCK SEIZURE (MES) MODEL IN RATS
... Materials & methods: For the assessment of anticonvulsant activity, the animals were divided into five groups of five animals each albino rats. Group I received Normal saline, Group II received Phenytoin, Group III ...
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“Lamotrigine and Memory Impairment Associated with Generalized Seizures: A Study on Maximal Electroshock Seizure Model of Mice” by Asher John Mohan, Krishna Kamsagara Linganna, India.
... Abolishment of extensor phase, escape latency time (ELT) and time spent in target quadrant (TSTQ) were the parameters observed. Mechanistic studies involved the determination of acetylcholiesterase (AChE) and glutamate ...
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Title: ANTICONVULSANT SCREENING OF HYDRO-ALCOHOLIC ROOT EXTRACT OF BERBERIS ARISTATA IN MICE Author: Chauhan S. Suchita and Sharma K. Hemant Keyword: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy.Page No: 01-06Abstract: Objective: To explore anti-convulsant potential of hydro-alcoholic extract of Berberis aristata (B. aristata) from pentylenetetrazole-induced and maximal electroshock (MES) seizure test. Material & Me thods: The test groups receive different doses (50, 100, 250 and 500 mg/kg) of the hydro-alcoholic extract; however positive control (standard) Phenobarbitone (20 mg/kg) using for Pentylenetetrazole-induced Seizure and Diazepam (1mg/kg) used as standard for maximal electroshock induced seizure. Swiss albino mice weigh about 20-25 g of either sex selected for the investigation. Results: Phytochemical investigation reveals that occurrence of alkaloids, flavonoids in the hydro-alcoholic root extract of Berberis aristata. Acute toxicity study shows no morality action up to 1000 mg/kg dose after 72 h observation. Hydro-alcoholic extract of B. aristata offered a concentration depending upon act of pentylenetetrazole-induced seizure (PTZ) and maximal electroshock induced seizure (MES). Conclusions: These finding suggest that hydro-alcoholic extract of B. aristata remarkable effect in the treatment in epilepsy. Key-words: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy. Download PDF
... and maximal electroshock (MES) seizure ...The test groups receive different doses (50, 100, 250 and 500 mg/kg) of the hydro-alcoholic extract; however positive control (standard) ...
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Title: ANTICONVULSANT SCREENING OF HYDRO-ALCOHOLIC ROOT EXTRACT OF BERBERIS ARISTATA IN MICE Author: Chauhan S. Suchita and Sharma K. Hemant Keyword: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy.Page No: 01-06Abstract: Objective: To explore anti-convulsant potential of hydro-alcoholic extract of Berberis aristata (B. aristata) from pentylenetetrazole-induced and maximal electroshock (MES) seizure test. Material & Me thods: The test groups receive different doses (50, 100, 250 and 500 mg/kg) of the hydro-alcoholic extract; however positive control (standard) Phenobarbitone (20 mg/kg) using for Pentylenetetrazole-induced Seizure and Diazepam (1mg/kg) used as standard for maximal electroshock induced seizure. Swiss albino mice weigh about 20-25 g of either sex selected for the investigation. Results: Phytochemical investigation reveals that occurrence of alkaloids, flavonoids in the hydro-alcoholic root extract of Berberis aristata. Acute toxicity study shows no morality action up to 1000 mg/kg dose after 72 h observation. Hydro-alcoholic extract of B. aristata offered a concentration depending upon act of pentylenetetrazole-induced seizure (PTZ) and maximal electroshock induced seizure (MES). Conclusions: These finding suggest that hydro-alcoholic extract of B. aristata remarkable effect in the treatment in epilepsy. Key-words: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy. Download PDF
... Kneading time on Granule properties and Dissolution profile using DOE Design of The quality‐by‐design QbD approach used in Experiment development of combination therapy for Materials and[r] ...
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Title: ANTICONVULSANT SCREENING OF HYDRO-ALCOHOLIC ROOT EXTRACT OF BERBERIS ARISTATA IN MICE Author: Chauhan S. Suchita and Sharma K. Hemant Keyword: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy.Page No: 01-06Abstract: Objective: To explore anti-convulsant potential of hydro-alcoholic extract of Berberis aristata (B. aristata) from pentylenetetrazole-induced and maximal electroshock (MES) seizure test. Material & Me thods: The test groups receive different doses (50, 100, 250 and 500 mg/kg) of the hydro-alcoholic extract; however positive control (standard) Phenobarbitone (20 mg/kg) using for Pentylenetetrazole-induced Seizure and Diazepam (1mg/kg) used as standard for maximal electroshock induced seizure. Swiss albino mice weigh about 20-25 g of either sex selected for the investigation. Results: Phytochemical investigation reveals that occurrence of alkaloids, flavonoids in the hydro-alcoholic root extract of Berberis aristata. Acute toxicity study shows no morality action up to 1000 mg/kg dose after 72 h observation. Hydro-alcoholic extract of B. aristata offered a concentration depending upon act of pentylenetetrazole-induced seizure (PTZ) and maximal electroshock induced seizure (MES). Conclusions: These finding suggest that hydro-alcoholic extract of B. aristata remarkable effect in the treatment in epilepsy. Key-words: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy. Download PDF
... Hospital solid waste includes anatomical, pathological, infectious, noninfectious, sharp objects, kitchen waste and general waste Paper, cardboard, plastic, etc... Despite the existence [r] ...
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Title: ANTICONVULSANT SCREENING OF HYDRO-ALCOHOLIC ROOT EXTRACT OF BERBERIS ARISTATA IN MICE Author: Chauhan S. Suchita and Sharma K. Hemant Keyword: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy.Page No: 01-06Abstract: Objective: To explore anti-convulsant potential of hydro-alcoholic extract of Berberis aristata (B. aristata) from pentylenetetrazole-induced and maximal electroshock (MES) seizure test. Material & Me thods: The test groups receive different doses (50, 100, 250 and 500 mg/kg) of the hydro-alcoholic extract; however positive control (standard) Phenobarbitone (20 mg/kg) using for Pentylenetetrazole-induced Seizure and Diazepam (1mg/kg) used as standard for maximal electroshock induced seizure. Swiss albino mice weigh about 20-25 g of either sex selected for the investigation. Results: Phytochemical investigation reveals that occurrence of alkaloids, flavonoids in the hydro-alcoholic root extract of Berberis aristata. Acute toxicity study shows no morality action up to 1000 mg/kg dose after 72 h observation. Hydro-alcoholic extract of B. aristata offered a concentration depending upon act of pentylenetetrazole-induced seizure (PTZ) and maximal electroshock induced seizure (MES). Conclusions: These finding suggest that hydro-alcoholic extract of B. aristata remarkable effect in the treatment in epilepsy. Key-words: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy. Download PDF
... analytical test results or references for same, as well as any pertinent observations; Conclusions regarding the acceptability of the results, and the status of the procedure(s) being validated; any ...
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Title: ANTICONVULSANT SCREENING OF HYDRO-ALCOHOLIC ROOT EXTRACT OF BERBERIS ARISTATA IN MICE Author: Chauhan S. Suchita and Sharma K. Hemant Keyword: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy.Page No: 01-06Abstract: Objective: To explore anti-convulsant potential of hydro-alcoholic extract of Berberis aristata (B. aristata) from pentylenetetrazole-induced and maximal electroshock (MES) seizure test. Material & Me thods: The test groups receive different doses (50, 100, 250 and 500 mg/kg) of the hydro-alcoholic extract; however positive control (standard) Phenobarbitone (20 mg/kg) using for Pentylenetetrazole-induced Seizure and Diazepam (1mg/kg) used as standard for maximal electroshock induced seizure. Swiss albino mice weigh about 20-25 g of either sex selected for the investigation. Results: Phytochemical investigation reveals that occurrence of alkaloids, flavonoids in the hydro-alcoholic root extract of Berberis aristata. Acute toxicity study shows no morality action up to 1000 mg/kg dose after 72 h observation. Hydro-alcoholic extract of B. aristata offered a concentration depending upon act of pentylenetetrazole-induced seizure (PTZ) and maximal electroshock induced seizure (MES). Conclusions: These finding suggest that hydro-alcoholic extract of B. aristata remarkable effect in the treatment in epilepsy. Key-words: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy. Download PDF
... Ekta Madan 2012, Environmental Auditing As A Management Tool For Evaluation of Category Wise Biomedical Waste [BMW Rules, 1998] And Its Practices In Hospitals In India, International Jou[r] ...
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Title: ANTICONVULSANT SCREENING OF HYDRO-ALCOHOLIC ROOT EXTRACT OF BERBERIS ARISTATA IN MICE Author: Chauhan S. Suchita and Sharma K. Hemant Keyword: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy.Page No: 01-06Abstract: Objective: To explore anti-convulsant potential of hydro-alcoholic extract of Berberis aristata (B. aristata) from pentylenetetrazole-induced and maximal electroshock (MES) seizure test. Material & Me thods: The test groups receive different doses (50, 100, 250 and 500 mg/kg) of the hydro-alcoholic extract; however positive control (standard) Phenobarbitone (20 mg/kg) using for Pentylenetetrazole-induced Seizure and Diazepam (1mg/kg) used as standard for maximal electroshock induced seizure. Swiss albino mice weigh about 20-25 g of either sex selected for the investigation. Results: Phytochemical investigation reveals that occurrence of alkaloids, flavonoids in the hydro-alcoholic root extract of Berberis aristata. Acute toxicity study shows no morality action up to 1000 mg/kg dose after 72 h observation. Hydro-alcoholic extract of B. aristata offered a concentration depending upon act of pentylenetetrazole-induced seizure (PTZ) and maximal electroshock induced seizure (MES). Conclusions: These finding suggest that hydro-alcoholic extract of B. aristata remarkable effect in the treatment in epilepsy. Key-words: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy. Download PDF
... Table 2: Safety factors for different dosage forms [1] Dosage form Safety factor Parenteral products 1000 - 10000 Oral solid dosage forms 100 - 1000 Topical preparations 10 - 100 10ppm c[r] ...
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Title: ANTICONVULSANT SCREENING OF HYDRO-ALCOHOLIC ROOT EXTRACT OF BERBERIS ARISTATA IN MICE Author: Chauhan S. Suchita and Sharma K. Hemant Keyword: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy.Page No: 01-06Abstract: Objective: To explore anti-convulsant potential of hydro-alcoholic extract of Berberis aristata (B. aristata) from pentylenetetrazole-induced and maximal electroshock (MES) seizure test. Material & Me thods: The test groups receive different doses (50, 100, 250 and 500 mg/kg) of the hydro-alcoholic extract; however positive control (standard) Phenobarbitone (20 mg/kg) using for Pentylenetetrazole-induced Seizure and Diazepam (1mg/kg) used as standard for maximal electroshock induced seizure. Swiss albino mice weigh about 20-25 g of either sex selected for the investigation. Results: Phytochemical investigation reveals that occurrence of alkaloids, flavonoids in the hydro-alcoholic root extract of Berberis aristata. Acute toxicity study shows no morality action up to 1000 mg/kg dose after 72 h observation. Hydro-alcoholic extract of B. aristata offered a concentration depending upon act of pentylenetetrazole-induced seizure (PTZ) and maximal electroshock induced seizure (MES). Conclusions: These finding suggest that hydro-alcoholic extract of B. aristata remarkable effect in the treatment in epilepsy. Key-words: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy. Download PDF
... Friability test: Friability is the loss of weight of tablet in the container due to removal of fine particles from the surface during transportation or handling. Roche friabilator was employed for finding the ...
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Anticonvulsant effect of Rosa damascena in pentylenetetrazole and maximal electroshock induced convulsions in albino rats
... Methods: MES model: rats were divided into 4 groups of 6 rats each. Group-I received 0.5% normal saline, group-II (standard) received phenytoin 25 mg/kg, group-III ,IV received low dose (200 mg/kg) and high dose (400 ...
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A Study on Effect of Trazadone, Amoxapine and Venlafaxine on MES (Maximal Electroshock) Induced Seizures In Albino Rats
... The bioamine theory of depression implicates that there is decreased level of 5-HT and norepinephrine. Most of the clinically used drugs in depression act by inhibiting reuptake of 5-HT or norepinephrine or both. ...
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Anticonvulsant and antioxidant activity of aqueous leaves extract of Desmodium triflorum in mice against pentylenetetrazole and maximal electroshock induced convulsion
... Department of Pharmacology and Toxicology, St. John’s Pharmacy College, Bangalore, Karnataka, India. Abstract: The present investigation was aimed to study an anticonvulsant activity of aqueous extract of Desmodium ...
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THE PHYSIOLOGICAL MEANING OF THE MAXIMAL OXYGEN INTAKE TEST
... Values for cardiac output and A V 0, difference in six normal subjects at the maximal oxygen intake and at a higher workload. Maximal oxygen intake level Beyond maximal oxygen intake lev[r] ...
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Fourth Amendment Protection against Unreasonable Seizure of the Person: The New Common Law Arrest Test for Seizure
... In concluding that a Fourth Amendment seizure had occurred, the Court of Appeal utilized the rationale of Michigan v. I think this was clearly illegal. Relying on the United[r] ...
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Stationary roller versus velodrome for maximal cycling test: A comparison
... between test conditions, is related to the constant resistance of the ergometer brake, requiring cyclists to maintain a constant muscle tension during each pedal ...
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Multi Stage 20 m Shuttle Run Fitness Test, Maximal Oxygen Uptake and Velocity at Maximal Oxygen Uptake
... The prediction models for the evaluation of vVO 2 max and VO 2 max, aerobic fitness and performance using the 20mMSFT can be used as appropriately accurate tools when direct measurements in a laboratory are not possible ...
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A conditional independence test for dependent data based on maximal conditional correlation
... for Test 1 and Test 2 at significance level 5% when the sample sizes are 100 and 200 ...causality test (hereafter denoted by Test LIN) and our conditional independence test (Test ...
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