The mechanism that prevents
Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1 dependent mechanism
... QCT prevents excito- toxic MN death, paralysis and gliosis, in part through a SIRT1-dependent mechanism, because the specific inhibitor EX527 partially suppressed QCT-exerted neu- roprotective ...
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A new mechanism of action of sulodexide in diabetic nephropathy: inhibits heparanase 1 and prevents FGF 2 induced renal epithelial mesenchymal transition
... The treatment of DN demands additional therapeutic strategies because strict glycemic control may prove dif- ficult to achieve in diabetic patients and, even if patients respond to conventional therapy with ACE ...
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Original Article Trimetazidine prevents pirarubicin-induced myocardial damage: a possible antioxidant mechanism
... possible mechanism of action of trimetazidine in pirarubicin-induced myocardial ...The mechanism underlying this effect may be related to its antioxidative ...
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Interferon Gamma Prevents Infectious Entry of Human Papillomavirus 16 via an L2-Dependent Mechanism
... IMPORTANCE A subset of HPV are the causative agents of many human cancers, most notably cervical cancer. This work describes the inhibition of infection of multi- ple HPV types, including oncogenic types, by treatment ...
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Original Article Cordyceps sinensis prevents contrast-induced nephropathy in diabetic rats: its underlying mechanism
... important mechanism in contrast-induced nephropathy ...the mechanism of its ...underlying mechanism may be that CS accelerates the recovery of renal function and renal pathology by reducing local ...
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Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP
... DISCUSSION This study demonstrates that MPTP opening is critical to experi- mental AP, mediating impaired ATP production, defective autop- hagy, zymogen activation, inflammatory responses and necrosis (figure 8), features ...
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Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP.
... DISCUSSION This study demonstrates that MPTP opening is critical to experi- mental AP, mediating impaired ATP production, defective autop- hagy, zymogen activation, in flammatory responses and necrosis ( figure 8 ), ...
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Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL 4 dependent mechanism
... effectively prevents destructive insulitis and protects from IDDM in NOD mice, provided that treatment is per- formed at a sufficiently early age (2–4 wk) during neonatal ...
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What prevents Struthio camelus and Dromaius novaehollandiae (Palaeognathae) from choking? A novel anatomical mechanism in ratites, the linguo-laryngeal apparatus
... In this study we aim to marry the functional data on living Ratidae and morphological observations on fresh and preserved material to demonstrate how the intricate relationship between the variably structured tongue ...
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An insect trap as habitat: cohesion failure mechanism prevents adhesion of Pameridea roridulae bugs to the sticky surface of the plant Roridula gorgonias
... SUMMARY The glandular trichomes of the plant Roridula gorgonias release an extremely adhesive, visco-elastic, resinous secretion that traps a variety of insects, including those having a considerable body size. However, ...
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Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism
... The mechanism of inducing miRNAs may be safe, if recently published reports suggesting that quiescent stem cell populations are dispensable for normal homeostatic processes, but are likely activated during ...
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Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1 induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44 dependent mechanism
... The mechanism by which injected HA exerts CD44- dependent anti-fibrotic effects in murine OA appears related to the finding [33] that the fibroblast to myofibro- blast transition in progressive murine lung ...
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In vivo expression of neutrophil inhibitory factor via gene transfer prevents lipopolysaccharide induced lung neutrophil infiltration and injury by a beta2 integrin dependent mechanism
... NIF also prevented the adhesion of mouse PMN to immobi- lized fibrinogen and to endothelial cells in culture (Fig. 4 B). In vivo expression of NIF in mouse lungs prevents LPS- induced PMN sequestration and lung ...
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Astragaloside-IV prevents acute kidney injury and inflammation by normalizing muscular mitochondrial function associated with a nitric oxide protective mechanism in crush syndrome rats
... protection mechanism was related to the nitric oxide (NO) generated by activation of endothelial nitric oxide synthase, which provided an anti-oxidative and anti-inflammatory ...
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PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis
... However, the underlying mechanism remains elusive. Moreover, it is also unclear in NASH whether PTPRO promotes autophagy by controlling p53. To figure out the exact role of PTPRO in NASH and autophagy, we employed ...
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Retinoic acid prevents experimental Cushing syndrome
... The effects of retinoic acid in vitro are paralleled by the effects we observed in vivo, and furthermore they cooperate to suppress the symptoms of Cushing syn- drome. Retinoic acid inhibition of proliferation and ...
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Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity
... release mechanism, the Korsmeyer–Peppas model was applied and release exponent (n) and the constant Table1 Particle size, zeta potential, and silymarin entrapment in ...
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Deoxyglucose prevents neurodegeneration in culture by eliminating microglia
... The mechanism by which DOG protected neurons ap- pears to be via depletion of microglia based on our findings that DOG did deplete microglia, that depleting microglia with LME also protected neurons, and that ...
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Early Learning Prevents
... Indeed, the preschool years are the crucial time for children to learn how to substitute socially appropriate strategies for physical, verbal, and indirect aggression.. The most effe[r] ...
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Supernilpotence prevents dualizability
... It shows that it is really supernilpotence which prevents dualizability, not nilpotence on its own. It also demonstrates that Theorem 1.1 does not generalize to algebras of infinite type. Our example appears to be ...
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