The miRNA biogenesis pathway
Computational modeling of mirna Biogenesis
... of miRNA processing, enable a better understanding of miRNA-mediated regulation in tissue-specific ...of miRNA promoters. Although the basics of the miRNA biogenesis pathway are ...
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Chapter Five Development of reporter systems for probing the mirna pathway
... of miRNA biogenesis and downstream effector ...the miRNA biogenesis pathway have been identified from siRNA-mediated gene silencing and biochemical studies such as pulling down protein ...
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AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity.
... the miRNA-silencing pathway as well as partial overlap with the siRNA-silencing ...for miRNA biogenesis or ...in miRNA silencing in flies have been previously ...a miRNA plus one ...
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AutomiG, a biosensor to detect alterations in mirna biogenesis and in small RNA silencing guided by perfect target complementarity.
... the miRNA-silencing pathway as well as partial overlap with the siRNA-silencing ...for miRNA biogenesis or ...in miRNA silencing in flies have been previously ...a miRNA plus one ...
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The significance of mirna pathway in peripheral nerve regeneration following sciatic nerve injury.
... of miRNA biogenesis to injury, the physiological significance of it was elucidated in the second part of the ...the miRNA processing enzymes Dicer, causing a deduction of all miRNA ...studies, ...
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Review, Hypothesis The Meaning of the Microprocessor: Accounting for Evolution of Structural-Functional Novelty in the Canonical microRNA Biogenesis Pathway.
... Microprocessor, miRNA, Drosha, Pasha, miRNA biogenesis pathway, Holozoa, Metazoa, RNA interference, bona fide miRNA, canonical eumetazoan ...eumetazoan miRNA, the detection of ...
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Regulation of Plant miRNA Biogenesis
... The possible cross-talk between these cis-regulatory elements and transcription factors leading to specific expression of miRNAs is not very well understood. Similarly, nature of transcriptional regulation of recently ...
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Hypoxia Mediated Downregulation of miRNA Biogenesis Promotes Tumor Progression
... with miRNA expression data from miRNA array analysis of A2780 cells exposed to hypoxia and ...Ingenuity Pathway Network analysis of mRNA and miRNA data from deep sequencing identified key novel ...
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A Baculovirus-Encoded MicroRNA (miRNA) Suppresses Its Host miRNA Biogenesis by Regulating the Exportin-5 Cofactor Ran
... Ran-mediated transport machinery, resulting in higher-level transport of pre-bmnpv-miR-1 into the cytoplasm and, at the same time, limiting the transport of host pre-miRNAs. These speculations draw credence from recent ...
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INVESTIGATING THE ROLES OF THE p63 ISOFORMS IN THE MICRORNA BIOGENESIS PATHWAY
... 163 4.3. Discussion Here, we show that deletion or knock down of ΔNp63 or DGCR8 in primary mouse and human epidermal keratinocytes, respectively, results in efficient reprogramming of cells with remarkable plasticity ...
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Mouse mirna-709 directly regulates mirna-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microrna hierarchy system
... and miRNA function-required argonaute family proteins in the cell nucleus have prompted us to hypothesize that miRNAs may also have regula- tory functions in the cell ...one miRNA can control the ...
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The miRNA Biogenesis Machinery Modulates Lineage Commitment During αβ T Cell Development
... miRNAs. Intracellular staining experiments to examine STAT5 phosphorylation after IL-‐7 treatment in WT and Dicer -‐/-‐ T cells could further clarify the role of this pathway in promoting survival of Dicer ...
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Widespread regulation of miRNA biogenesis at the Dicer step by the cold-inducible RNA-binding protein, RBM3
... of miRNA biogenesis at post-transcriptional steps by RNA-binding proteins is a key point of regulatory control over the expression of some miRNAs and the cellular processes they ...the miRNA ...
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Functional Redundancy of DICER Cofactors TARBP2 and PRKRA During Murine Embryogenesis Does Not Involve miRNA Biogenesis.
... Maternally supplied Dicer mRNA is expressed in murine oocytes, reaching its highest levels in germinal vesicle-stage oocytes, and then falling to its lowest detectable level in eight-cell-stage embryos (Murchison et al. ...
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Review. MicroRNAs in Tumorigenesis. A Primer. Biogenesis of mirna. Basic Biology of MicroRNAs A Brief History of MicroRNA Discovery
... the miRNA/miRNA*, is released. The RISC, containing its miRNA, binds to the target mRNA and direct mRNA cleavage or translational repression based on sequence ...ference pathway of small ...
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Critical roles of RNA-binding proteins in miRNA biogenesis in Arabidopsis
... Clearly, RNA-binding proteins play critical roles in regulating the cellular levels of miRNAs in plants. A big challenge is to dissect how these RNA-binding proteins co-operate with DCL1 to regulate miRNA ...
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Terminal loop-mediated regulation of mirna biogenesis: selectivity and mechanisms
... has been shown recently that the recognition of miR-7 TL by HuR inhibits pri-miRNA processing [44]. In summary, the regulators of RNA biogenesis are multifunctional proteins not only involved in ...
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Alternative use of miRNA biogenesis co factors in plants at low temperatures
... as miRNA processing have to be adjusted to fluctuating environmental ...plant miRNA biogenesis machinery becomes more robust, producing miRNAs even in the absence of the key DCL1 co-factors HYL1 and ...
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A functional endosomal pathway is necessary for lysosome biogenesis in Drosophila
... To date, two alternative models for lysosome biogen- esis have been proposed [43]. In the maturation model, Fig. 2 Defects in the endosomal pathway affect the distribution of the lysosomal hydrolase Cathepsin L. ...
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Secretory Protein Biogenesis and Traffic in the Early Secretory Pathway
... secretory pathway, which handles the various proteins that are destined for the extracellular environment or retention in the internal endo- membrane ...anterograde pathway is balanced by a reverse, or ...
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