The Oxidative Pentose Phosphate Pathway
Increased expression of the oxidative pentose phosphate pathway and gluconeogenesis in anaerobically growing xylose-utilizing Saccharomyces cerevisiae
... the oxidative pentose phosphate pathway coin- cided with anaerobiosis (Figure ...the oxidative PPP is explained by need for NADP+ reduction in anerobic co-factor recycling ...the ...
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Overcompensation in Response to Herbivory in Arabidopsis thaliana: The Role of Glucose-6-Phosphate Dehydrogenase and the Oxidative Pentose-Phosphate Pathway
... Results here support the utility of using a combinatorial approach of QTL mapping and microarray data in uncover- ing potential candidate genes. As Wayne and McIntyre (2002, pp. 14,903) pointed out, “The use of ...
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The oxidative pentose phosphate pathway in the haloarchaeon Haloferax volcanii involves a novel type of glucose-6-phosphate dehydrogenase – The archaeal Zwischenferment
... In summary, we report here that H. volcanii utilizes the OPPP for the synthesis for pentose phosphates from glucose-6-phosphate involving a novel type of Glc6PDH and bacterial type of 6PGDH. The first ...
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Enzyme activity highlights the importance of the oxidative pentose phosphate pathway in lipid accumulation and growth of Phaeodactylum tricornutum under CO2 concentration
... Microalgal lipids, as a source of biofuel, are usually de- rived from long-chain fatty acids, which require NADPH for synthesis [21, 22]. For example, to produce an 18- carbon fatty acid, 16 NADPH molecules are required ...
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Characterization and inhibition of NADPH-producing enzymes from the pentose phosphate pathway of Plasmodium parasites
... to oxidative stress from different ...dinucleotide phosphate (NADPH) are employed to maintain the redox ...of oxidative stress by disturbing cellular redox ...the oxidative pentose ...
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SUBSTANCES STIMULATING GLUCOSE CATABOLISM BY THE OXIDATIVE REACTIONS OF THE PENTOSE PHOSPHATE PATHWAY IN HUMAN ERYTHROCYTES
... It has been demonstrated that human erythrocytes deficient in glucose-6- phosphate dehydrogenase (G6PD) are unable to maintain their level of reduced glutathione upon incubation with a v[r] ...
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The ability of cells to counteract oxidative stress is. Methionine Metabolism Alters Oxidative Stress Resistance via the Pentose Phosphate Pathway
... the oxidative stress response, and acting as a reactive oxygen species scavenger, methionine is implicated in caloric restriction phenotypes and ...dinucleotide phosphate (NADPH) producing oxidative ...
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The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
... sugar phosphate precursors for the synthesis of amino ...the oxidative PPP is considered unidirectional, the non-oxidative branch can supply glycolysis with intermediates derived from ribose ...
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Emerging role of the pentose phosphate pathway in hepatocellular carcinoma
... PeRSPeCTiveS Oxidative PPP activation can help transformed cells to escape oxidative stress by increasing the intracellular redox power of cancer cells through enhanced NADPH ...this pathway as ...
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The return of metabolism : biochemistry and physiology of the pentose phosphate pathway
... The oxidative branch is highly active in most eukaryotes and converts glucose 6-phosphate into carbon dioxide, ribulose 5-phosphate and ...sugar phosphate precursors for the synthesis of amino ...
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The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy
... cOnclUsIOns Cancer cells adapt their metabolic circuitry to support pro- liferation under nourished fast-life as well as to survive un- der starved slow-life. Emerging evidence suggests that PPP flux is increased in ...
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Expression of Pentose Phosphate Pathway-Related Proteins in Breast Cancer
... the pentose phosphate pathway is an indispensable metabolic pathway in malignant tumors because of the demand for a high rate of nucleic acid synthesis during growth and the NADPH necessary ...
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Enzyme characterisation and kinetic modelling of the pentose phosphate pathway in yeast
... Table 7: Flux control coefficients in the PPP model in (a) the reference state and (b) following oxidative stress. The rows represent the fluxes under control, and the columns represent the controlling reactions. ...
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The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration
... Studies in animal models and patients have shown glu- cose metabolism disruption in PD [2, 13, 14]. For in- stance, PD patients exhibit a decrease in glucose metabolism and abnormal elevation in levels of lactate/ ...
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Expression of Pentose Phosphate Pathway-Related Proteins in Breast Cancer
... the pentose phosphate pathway is an indispensable metabolic pathway in malignant tumors because of the demand for a high rate of nucleic acid synthesis during growth and the NADPH necessary ...
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Handling Uncertainty in Dynamic Models:The Pentose Phosphate Pathway in Trypanosoma brucei
... and pentose phosphate pathways, expanding on the modeling strategy intro- duced in ...under oxidative stress was nearly identical, while the inhibition of 6PGDH only showed minor differences between ...
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Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway
... increased oxidative stress produced by enhanced NADPH oxidase activity, which is also occurring in dia- betes [12], it seems reasonable to conclude that a path- way linking the over-activation of PPP with the ...
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Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes
... The pentose phosphate pathway (PPP) is a fundamental element of cell biochemistry since it is the major pathway for the recycling of NADP + to NADPH and for the production of ...
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A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
... Interestingly, we discovered that 6-phosphogluconate dehy- drogenase (Pgd) gene expression and downstream metabolites were blunted in HFD macrophages. In accordance, knockdown of PGD was found to reduce the ...
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The study of RAS-induced metabolic reprogramming and the role of the pentose phosphate pathway in tumor metabolism
... the oxidative branch, is especially attractive since it also targets the ROS protection system of cancer ...enhanced oxidative stress and increased sensitivity to oxidative damage, indicating that ...
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