The sarcoplasmic reticulum (SR)
Ma2/d promotes myonuclear positioning and association with the sarcoplasmic reticulum
... Muscle, Sarcoplasmic reticulum, Drosophila INTRODUCTION Fully differentiated skeletal muscle fibers are multinucleated, elongated cells with highly ordered cytoplasm, essential for efficient muscle ...
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The role of the sarcoplasmic reticulum in the generation of high heart rates and blood pressures in reptiles
... the sarcoplasmic reticulum (SR) in the generation of high heart rates and blood pressures was investigated in four species of reptile; the turtle, Trachemys scripta; the python, Python regius, the tegu ...
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Steroid induced cardiac contractility requires exogenous glucose, glycolysis and the sarcoplasmic reticulum in rainbow trout
... Stimulation of the cardiac contractile state, or positive inotropy, can occur through several diverse mechanisms Recent data from our laboratory suggest that sex steroids promote contractile function in cardiac muscle of ...
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High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with acidic stores (lysosomes) in the heart
... Daniel Aston 1,† , Rebecca A. Capel 1,† , Kerrie L. Ford 2 , Helen C. Christian 2 , Gary R. Mirams 3 , Eva A. Rog-Zielinska 4 , Peter Kohl 4,5 , Antony Galione 1 , Rebecca A. B. Burton 1,* & Derek A. Terrar 1,* Nicotinic ...
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Doxorubicin cardiomyopathy is associated with a decrease in calcium release channel of the sarcoplasmic reticulum in a chronic rabbit model
... D A Dodd, … , S Fleischer, R J Boucek Jr J Clin Invest. 1993;91(4):1697-1705. https://doi.org/10.1172/JCI116379. Doxorubicin is a highly effective cancer chemotherapeutic agent that produces a dose- dependent ...
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The sarcoplasmic reticulum plays a major role in isometric contraction in atrial muscle of yellowfin tuna
... At low pacing frequencies, the temperature-dependency of SR Ca 2+ utilization in yellowfin tuna atrium is similar to that observed for trout ventricle, with a greater ryanodine response[r] ...
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Depletion of Ca2+ from the sarcoplasmic reticulum of cardiac muscle prompts phosphorylation of phospholamban to stimulate store refilling
... In conclusion, cardiac myocytes increase phospholamban phosphorylation in response to store depletion. A phospho- lamban kinase associated with cardiac SR vesicles and sensitive to high [r] ...
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Comparative studies on the sarcoplasmic reticulum of fish muscle
... et al. 1 976 )o Pukushima et al (1977) have produced evidence to suggest that the key enzyme in this acclimatory process may be palmitoyl coenzyme A desaturase, which is located on the endoplasmic reticulum of the ...
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3D ultrastructural organisation of calcium release units in the avian sarcoplasmic reticulum
... ABSTRACT Excitation – contraction coupling in vertebrate hearts is underpinned by calcium (Ca 2+ ) release from Ca 2+ release units (CRUs). CRUs are formed by clusters of channels called ryanodine receptors on the ...
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Ca(2+) uptake in the sarcoplasmic reticulum from the systemic heart of octopod cephalopods
... We have measured Ca 2+ uptake in crude homogenates of heart tissue, as well as cell shortening and ionic currents in isolated myocytes exposed to caffeine, to characterize Ca 2+ uptake i[r] ...
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Coronary artery disease in metabolic syndrome: a role for the sarcoplasmic reticulum Ca2+ ATPase
... 205. Lipskaia L, Hadri L, Le Prince P, Esposito B, Atassi F, Liang L, Glorian M, Limon I, Lompre AM, Lehoux S, Hajjar RJ: SERCA2a gene transfer prevents intimal proliferation in an organ culture of human internal mammary ...
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Ca(2+)transport by the sarcoplasmic reticulum Ca(2+) ATPase in sea cucumber (Ludwigothurea grisea) muscle
... sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA) isoforms found in mammalian tissues are cation- transporting ATPases that belongs to the family of P-type or E1/E2 ...
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Spatial and Temporal Inhomogeneities During Ca 2 Release From the Sarcoplasmic Reticulum in Pig Ventricular Myocytes
... Predominantly, the data presented from rat, guinea pig, and mouse ventricular myocytes show a pattern of release marked by distances of ⬇2 m between foci, consis- tent with the presence[r] ...
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Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca2+ content in rat ventricular myocytes
... E. F. Bode, S. J. Briston, C. L. Overend, S. C. O’Neill, A. W. Trafford and D. A. Eisner Unit of Cardiac Physiology, University of Manchester, 3.18 Core Technology Facility, 46 Grafton Street, Manchester M13 9NT, UK ...
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Calcium transport by skeletal muscle sarcoplasmic reticulum in the hypothyroid rat
... The rate of calcium transport by isolated sarcoplasmic reticulum from rat skeletal muscle increases markedly during the first 4 wk of life and thereafter remains relatively constant. When animals are made ...
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Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells
... the sarcoplasmic reticulum than is exogenous ATP (Kaasik et ...mitochondria, sarcoplasmic reticulum and myofibrils [intracellular energetic units (ICEUs)] as a basic pattern of organization of ...
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Calcium Uptake and Release through Sarcoplasmic Reticulum in the Inferior Oblique Muscles of Patients with Inferior Oblique Overaction
... from sarcoplasmic reticulum into muscle cells, Ca 2+ -ATPase, which drives Ca 2+ uptake, and calsequestrin that binds with Ca 2+ ...the sarcoplasmic reticulum and Ca 2+ release from the ...
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OF SARCOPLASMIC RETICULUM
... Thus, if the protein scattering curve can be determined by fitting a model curve to the experimental intensity at any one solvent density, it can easily be scaled according to the square[r] ...
Ca++ Uptake and ATPase of Human Sarcoplasmic Reticulum
... ATPase activity of grana obtained from human white muscle was only slightly inhibited by sodium azide; purified grana activity showed little or no inhibi- tion by azide (Table III).. The[r] ...
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Sarcoplasmic Reticulum Ca release in Intact Ventricular Myocytes
... The chronic hyperadrenergic state of heart failure is associated with defective Ca 2+ signaling in part due to PKA hyperphosphorylation of RyR2. INTRODUCTION Although we now understand a great deal more about the systems ...
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