the third component of complement
Inherited Deficiency of the Third Component of Complement Associated with Recurrent Pyogenic Infections, Circulating Immune Complexes, and Vasculitis in a Dutch Family
... The complement system has an important func- tion in host defense against infections and is in- volved in the processes of inflammation.’ The third component of complement (C3) plays a c[r] ...
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Biosynthesis of the third component of complement (C3) in vitro by monocytes from both normal and homozygous C3 deficient humans
... Human monocytes synthesized the third component of complement (C3) up to 5 wk in vitro. Evidence for net C3 synthesis was based on (a) incorporation of 14C-labeled amino acids into C3 protein, (b) ...
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Measurement of the Third Component of Complement Bound to Red Blood Cells in Patients with the Cold Agglutinin Syndrome
... the third component of complement (C3) bound to red cells of patients with the cold agglutinin syndrome was determined by a quantitative assay, measuring the fixation of the first component of ...
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Inherited deficiency of the third component of human complement (C′3)
... the third component of complement ...Hemolytic complement titers were slightly reduced but immune adherence titers and reagent titrations of the classical complement components were ...
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Acute local inflammation alters synthesis, distribution, and catabolism of third component of complement (C3) in rabbits
... the third component of complement (C3) during inflammation, we injected purified radiolabeled C3 into normal New Zealand White rabbits and into rabbits with turpentine-induced ...
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Pretranslational regulation of the synthesis of the third component of complement in human mononuclear phagocytes by the lipid A portion of lipopolysaccharide
... The third component of complement (C3) is a plasma glycoprotein with a variety of biologic functions in the initiation and maintenance of host response to infectious ...
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Metabolic Studies of the Third Component of Complement and the Glycine Rich Beta Glycoprotein in Patients with Hypocomplementemia
... radioiodine-labeled third component of complement (C3) and the glycine-rich b glycoprotein (GBG), a major component of the C3b-feedback pathway, were undertaken in normal subjects, in 22 ...
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In vivo metabolism of complement: I Metabolism of the third component (C′3) in acquired hemolytic anemia
... purified third component of complement labeled with 125 -iodine (C¢3- 125 I) was studied in normal subjects and in patients with acquired hemolytic ...
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Complete absence of the third component of complement in man
... A 4-yr-old female patient who has recurrent infections with encapsulated bacteria and gramnegative organisms was found to have a complete absence of total hemolytic complement and C3. Total hemolytic ...
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Cigarette smoke can activate the alternative pathway of complement in vitro by modifying the third component of complement
... subsequent addition to serum (containing Mg/EGTA to block the classical pathway) results in consumption of hemolytic complement by activation of the alternative pathway. Smoke- modified C3 shows increased anodal ...
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Genetic polymorphism of the third component of human complement (C′3)
... The allotypes appear to differ in net surface charge at pH 8.6, but show no obvious differences in complement activity, in molecular size, or in binding of Ca ++ . The concentrations of the two gene products in ...
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Identification of a third component of complement binding glycoprotein of human platelets
... features. Functional characterization of solubilized platelet preparations indicated that gp45- 70 has cofactor activity. This membrane glycoprotein is structurally and antigenically distinct from decay accelerating ...
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Molecular basis of complement C3 deficiency in guinea pigs
... the third component of complement (C3) in guinea pigs, we found that C3-deficient liver and peritoneal macrophages contain C3 messenger RNA of normal size (approximately 5 kb) and amounts, that this ...
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Metabolism of the fifth component of complement, and its relation to metabolism of the third component, in patients with complement activation
... parameters between patients with different types of complement activation. In patients with systemic lupus erythematosus, fractional catabolism and extravascular distribution of C3 and C5 were both increased, and ...
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Antiopsonic activity of fibrinogen bound to M protein on the surface of group A streptococci
... the third component of complement showed that streptococci incubated in fresh serum bound complement evenly over the entire cell surface, whereas streptococci incubated in fresh plasma or in ...
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Antigen heterogeneity of human B and T lymphocytes
... 'Abbreviations used in this paper: B cells, bone marrowderived lymphocytes; C3 receptor, receptor for third component of complement; CRL, complement receptor lymphocyte; CLL, chronic lym[r] ...
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Meningococcal Meningitis in Familial Deficiency of the Fifth Component of Complement
... episodes of disseminated gonococcal disease oc- curred in one of the two homozygous C5-deflcient patients.4 The occurrence of invasive Neisseria in all four C5-deflcient siblings in the [r] ...
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Postpartum thrombotic microangiopathy revealed as atypical hemolytic uremic syndrome successfully treated with eculizumab: a case report
... and complement activa- tion ...alternative complement pathway and can present in both children and adults ...in complement regulatory genes has been identified ...
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Monocyte surface expression of Fcγ receptor RI (CD64), a biomarker reflecting type I interferon levels in systemic lupus erythematosus
... Dysregulated CD64 expression may have functional consequences, as this activating FcγR plays important roles in phagocytosis, cytolysis, and induction of inflam- matory cytokines [28]. The balance of activating (CD16, ...
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The Complement System in Bullous Pemphigoid I COMPLEMENT AND COMPONENT LEVELS IN SERA AND BLISTER FLUIDS
... hemolytic complement was reduced in the blister fluid of six serologically positive bullous pemphigold patients while four serologically negative cases had blister fluid complement levels closely ...
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