the Toll-like receptor 2
A Toll-Like Receptor-2-Directed Fusion Protein Vaccine against Tuberculosis
... A fusion protein designated CSU-F36 was constructed that consisted of acylated Rv1411, a potent Toll-like receptor-2 agonist, fused to ESAT-6, a well-characterized immunogenic protein from ...
6
Tuberculosis State Is Associated with Expression of Toll-Like Receptor 2 in Sputum Macrophages
... IMPORTANCE Mycobacterium tuberculosis is an intracellular pathogen that parasit- izes the host macrophage. While approximately two billion people are infected worldwide, only 5 to 10% become diseased with pulmonary ...
7
Decreased Levels of Soluble Toll-Like Receptor 2 in Patients with Asthma
... Recently, the prevalence of asthma and allergies has increased dramatically in industrialized countries, and this increase cannot be explained by genetic changes. Respiratory infections have been linked to asthma in both ...
7
Toll-like receptor 2 deficiency leads to delayed exacerbation of ischemic injury
... Immunohistochemistry was performed according to the previously described protocol [3,11]. Brain sections of TLR2−/− and WT mice were collected 3, 7 and 14 days after the MCAO procedure (all the stroke region, n = 4 ...
17
Antagonistic antibody prevents toll like receptor 2–driven lethal shock like syndromes
... receptor-specific inhibition of microbial product–induced host cell activation. For example, application of CD14-specific anti- bodies inhibited LPS-induced cell activation, protected rabbits against LPS-induced ...
10
Toll-like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne
... The expression of functional TLRs in both interfollicular and infundibular human keratinocytes is consistent with an innate role for these cells in the sensing of, and re- sponse to, bacterial pathogens [17]. The ...
7
Toll-like receptor 2 plays a critical role in pathogenesis of acne vulgaris
... factor receptor-associated factor 6 (TRAF6) (Jenkins and Mansell 2010; Chen ...protein 2 (TAB2), this complex interacts with upstream kinases of p38, JNK, and inhibitor of NF-κB kinase (IKK) complex ...
6
Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis
... increases in TLR-4 and CD14 expression in wild type mice, which is likely an additional protective benefit of high saturated dietary fat. The influences of fats in vivo are in stark contrast to the effects of fatty acids ...
10
Toll like receptor 2 (TLR2) plays a role in controlling cutaneous leishmaniasis in vivo, but does not require activation by parasite lipophosphoglycan
... mannose receptor and enhance protective Th1 responses when administered with ...ligand- receptor complex, as has been achieved for other complexes such as LPS-TLR4-MD2, Pam2-TLR2/6, Pam3-TLR2/1 and ...
14
Toll like receptor 2 controls expansion and function of regulatory T cells
... poration and shown as average cpm of triplicates relative to medium control ± SD. (C) Proliferation of CFSE-labeled PAM-expanded Tregs. The labeled Tregs were cultured for 3 days in the presence of ...
11
Association between Toll Like Receptor 4 (Thr399Ile and Asp299Gly), Toll Like Receptor 2 196 174 Deletion Polymorphisms with cryptosporidiosis
... Our study results did not show association between TLR 4 Asp299Gly and Thr399Ile), TLR 2 (196_174 del) gene polymorphisms and cryptosporidiosis. This is in concordance with previous studies on other parasitic ...
12
Toll-like receptor 2 and type 2 diabetes
... Type 2 diabetes, also referred to as adult-onset diabetes or as non-insulin-dependent diabetes mellitus (NIDDM) is increasingly common [1, ...Type 2 diabetes correlates significantly with cardiovascular ...
9
Arg753gln and Arg677 Trp Polymorphisms of Toll-Like Receptor 2 In Acute Apical Abscess
... into two new 1.5 ml micro tubes containing 540 μl iso- propanol. Then, the tubes were inverted at least 20 times, and centrifuged again at 4000 rpm for 5 min. The pellet was recovered and allowed to air-dry before add- ...
9
Modulation of atherosclerosis in mice by Toll like receptor 2
... Epidemiologic evidence has established a relationship between microbial infection and atherosclerosis. Mammalian TLRs provide clues on the mechanism of this inflammatory cascade. TLR2 has a large ligand repertoire that ...
9
Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica
... TLR1 Toll-like receptor 1 TLR2 Toll-like receptor 2 TLR3 Toll-like receptor 3 TLR4 Toll-like receptor 4 TLR5 ...
37
The Toll Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge
... lethal influenza virus infection (13). Furthermore, the TLR4 antagonist eritoran pro- tected mice from lethal influenza virus infection. Activation of the TLR4 signaling pathway requires transfer of LPS molecules from ...
10
Toll like receptor downstream signaling
... MyD88 was originally identified as one of the myeloid differentiation primary response genes rapidly induced by IL-6 in M1 myeloleukemic cells. MyD88 contains two domains characterized by a death domain and a TIR domain, ...
8
Posttranslational Modification of HOIP Blocks Toll Like Receptor 4 Mediated Linear Ubiquitin Chain Formation
... alter the intrinsic enzymatic activity of HOIP (see Fig. S1F in the supplemental material). These experiments collectively demon- strate that HOIP is ubiquitinated at the K1056 by multiple types of ubiquitin chains and ...
12
Toll Like Receptor 3/TRIF Dependent IL 12p70 Secretion Mediated by Streptococcus pneumoniae RNA and Its Priming by Influenza A Virus Coinfection in Human Dendritic Cells
... In summary, we propose a model in which pneumococci are phagocytosed by DCs and degraded in the endolysosomal com- partment. The released pneumococcal RNA activates TLR3 and FIG 3 TLR3 is required for IL-12p70 production ...
10
Role of polymorphisms of toll like receptor (TLR) 4, TLR9, toll interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children
... of toll-like receptors (TLRs) ...extracellular receptor modules and initiating inflammatory signalling pathways through an intracellular domain ...the Toll- interleukin 1 receptor ...
8