The tricarboxylic acid [TCA] cycle
Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets
... the tricarboxylic acid (TCA) cycle and glyoxylate bypass, isocitrate dehydrogenase (ICD), involved in the TCA cycle, and ICL, involved in the glyox- ylate bypass, compete for the ...
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Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells
... of tricarboxylic acid (TCA) cycle enzymes can produce cells with low energy ...of TCA genes shows a broad Gaussian distribution in a population, with differences of over 3 orders of ...
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Omics-based analyses revealed metabolic responses of Clostridium acetobutylicum to lignocellulose-derived inhibitors furfural, formic acid and phenol stress for butanol fermentation
... formic acid > phenol > ...reductive tricarboxylic acid (TCA) cycle, acetone–butanol synthesis and redox metabolism were lower than those in the control ...oxidative TCA ...
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13C metabolic flux analysis on roles of malate transporter in lipid accumulation of Mucor circinelloides
... that tricarboxylic acid (TCA) cycle flux ratio of mt-overex- pression strains was decreased compared to that of the control strain, but in contrast, glyoxylic acid (GOX) cycle ...
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Integrating multi-omics analyses of Nonomuraea dietziae to reveal the role of soybean oil in [(4′-OH)MeLeu]4-CsA overproduction
... in tricarboxylic acid (TCA) cycle and amino acid ...succinic acid increased to ...of TCA cycle in medium ...
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Sugar and organic acid utilisation in Pachysolen tannophilus and Pichia stipitis : a thesis presented in partial fulfilment of the requirements for the degree in Master of Science in Genetics at Massey University
... Wild-type strains of the K+ yeasts Pachysolen tannophilus and Pichia stipitis were assessed for their ability to utilise tricarboxylic acid TCA cycle intermediates and to fennent glucose[r] ...
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Metabolic signatures differentiate ovarian from colon cancer cell lines
... Metabolites differentiating colon from ovarian cancer cell lines were grouped into different metabolic classes including amino acids, carbohydrates, energy-related metabolites, lipids, nucleotides, dipeptides, and ...
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Genetic and Biochemical Interactions Involving Tricarboxylic Acid Cycle (TCA) Function Using a Collection of Mutants Defective in All TCA Cycle Genes
... the tricarboxylic acid (TCA) cycle are encoded by at least 15 different nuclear genes in Saccharomyces ...the TCA cycle proteins. The 15 major TCA cycle genes can ...
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Metabolome- and genome-scale model analyses for engineering of Aureobasidium pullulans to enhance polymalic acid and malic acid production from sugarcane molasses
... for understanding cell metabolism and improving the production of target metabolites [16]. Metabolomics has been a powerful tool for understanding the intracellular metabolism with broad range of applications in various ...
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<p>Toxicity and serum metabolomics investigation of Mn-doped ZnS quantum dots in mice</p>
... lactate), tricarboxylic acid (TCA) cycle (citrate, malate and fumarate), ketoplasia ( β - hydroxybutyrate), glutaminolysis (glutamine and ...
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Genetic Evidence for Two Carbon Fixation Pathways (the Calvin-Benson-Bassham Cycle and the Reverse Tricarboxylic Acid Cycle) in Symbiotic and Free-Living Bacteria
... reverse tricarboxylic acid (rTCA) cycle and the recently discovered reversed oxidative TCA cycle (roTCA) (1, 3, ...CBB cycle in the symbionts and the large sulfur bacteria is ...
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A Dysfunctional Tricarboxylic Acid Cycle Enhances Fitness of Staphylococcus epidermidis During β Lactam Stress
... ⌬ TCA mutant in the presence or absence of sub-MIC oxacillin (32 ...⌬ TCA mutant surface, resulting in their enhanced proteolytic degrada- tion ( ⬍ 25 kDa) within the culture supernatant ...⌬ TCA ...
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Analysis of organic acids of tricarboxylic acid cycle in plants using GC-MS, and system modeling
... organic acid contents (Table ...oxylic acid (TCA) ...citric acid (source) and malic acid (sink) and explained ...malic acid content, whereas fumaric acid had a negative ...
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Rational modification of tricarboxylic acid cycle for improving l-lysine production in Corynebacterium glutamicum
... xylic acid (TCA) cycle, which provides several metabolic precursors and cofactors for cell growth and amino acids production ...in TCA cycle, such as phos- phoenolpyruvate ...
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Tricarboxylic acid cycle enzymes and bicarbonate fixation in morphogenesis of Blastocladiella emersonii.
... The main purpose of the work reported here was to re examine the behavior of the TCA cycle enzymes during the development of B. emersonii in synchronous cultures. It was hoped that such a study might offer ...
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Establishing an innovative carbohydrate metabolic pathway for efficient production of 2-keto-l-gulonic acid in Ketogulonicigenium robustum initiated by intronic promoters
... Results: In this study, Ketogulonicigenium robustum SPU_B003 was reported for its capability to grow well indepen‑ dently and to produce more 2‑KGA than that of K. vulgare in a mono‑culture system. The complete genome of ...
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Mitochondria as biosynthetic factories for cancer proliferation
... Mitochondrial proline metabolism and synthesis are critic- ally important for tumor cells, at least in part due to the unique, modifiable chemical properties it provides to proteins. Proline is synthesized from glutamine ...
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Role of granulocyte oxygen products in damage of Schistosoma mansoni eggs in vitro
... reduction in acetate metabolism vs. 28.3 +/- 0.9% decrease in controls without superoxide dismutase, P less than 0.0005) and hatching (12.5 +/- 1.8% reduction, P less than 0.0005), whereas catalase and heparin had no ...
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Complete genome sequence of Hydrogenobacter thermophilus type strain (TK-6T)
... cient hydrogen-oxidizing ability of this strain, which results in a faster generation time com- pared to other autotrophs. It is also able to grow anaerobically using nitrate as an electron acceptor when molecular ...
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Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver
... the TCA cycle, and susceptibility to inflammation and liver injury (23, ...reduced TCA cycle activity com- pared with similar subjects studied in the postabsorptive state ...
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