The tumour microenvironment
Adapting Immunotherapy to the Tumour Microenvironment
... • Universal approach to address amino acid limitations in the tumour microenvironment. Strong in vitro data including enhanced CAR-T proliferation (patent application filed). • Single, rational engineering ...
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The Role of microRNA-145 in the Tumour Microenvironment
... promote tumour growth and angiogenesis via the secretion of chemokines, ECM molecules and growth ...promoted tumour growth and angiogenesis within a human xenograft and that this was facilitated by stromal ...
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The role of mesenchymal stem cells in the tumour microenvironment
... The data from analyses performed in this chapter highlight the highly responsive and conditional nature of MSCs, demonstrating that exposure to the secretome of cancer cells and cancer-‐associated myofibroblasts can ...
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Development and characterization of a microfluidic model of the tumour microenvironment
... the tumour microenvironment upon drug response, three well-established drugs were ...the tumour microenvironment ...the tumour cells located in the ...
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Functional Roles for Exosomal MicroRNAs in the Tumour Microenvironment
... the tumour microenvironment may play a role in modulation of im- mune response in the tumour ...by tumour cells has been shown to inhibit expression of major histocompatibility complex (MHC) ...
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Immune profiling of the tumour microenvironment in prostate cancer
... B7-H3 is a newly discovered member of the B7 family of immune checkpoint molecules with both immune and non-immune functions. I investigated the relationship of B7-H3 to the tumour microenvironment as well ...
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Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours
... The tumour microenvironment (TME) consists of neo- plastic, immune and stromal cells together with enzymes, growth factors and cytokines within the extracellular matrix [5–7, 11, ...and tumour ...
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IL-6 Activities in the Tumour Microenvironment. Part 1
... by tumour cells, including IL-1β, TNF-α, IL-6 and TGF-β are considered to be promoters of Th17 differentiation from naïve CD4+ T ...the tumour microenvironment (TME) ...by tumour cells. They ...
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The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer
... between tumour cell anaerobic metabolism, the tumour microenvironment, and survival following surgery for stage I-III ...and tumour cell expression of cytoplasmic MCT-2 or nuclear LDH-5 was ...
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Molecular and cellular changes in the tumour microenvironment during IL-12 therapy
... the tumour microenvironment involve a variety of events exerted at different levels: the establishment of an anti-tumour immune response; direct toxicity against tumour cells and ...
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Enabling research into the tumour microenvironment: Novel Photonics Assays for Cancer Research
... the tumour microenvironment; and 3) Where to look: Novel surgical protocols to enable ultra-high-resolution optical imaging in living animals (intravital ...
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Immunologic cellular characteristics of the tumour microenvironment of hepatocellular carcinoma drive patient outcomes
... the tumour vicinity consists mainly of ...immunologic tumour infiltration influence its malig- nant behaviour and could provide clinically informative prognostic biomarkers [21 – ...the tumour ...
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Na+/H+ exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis?
... the tumour microenvironment: triggering metastasis Growth factor and nutrient-enriched serum activates NHE1 in normal cells while, paradoxically, serum deprivation activates NHE1 activity in cancer ...the ...
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Improving the understanding of platinum sensitivity and the tumour microenvironment in high grade serous ovarian cancer
... When the HR status of cell lines is analysed with the cisplatin and rucaparib IC50 levels there is a significant difference between HR status and rucaparib sensitivity (p=0.0001). However there is no difference between ...
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The interaction of the EGFR-PI3-K/AKT pathway with the tumour microenvironment in head and neck cancer
... the tumour microenvironment is of major influence on the response of tumours to ...treatment. Tumour progression is complex and difficult to ...The tumour microenvironment is involved ...
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Modelling and analysis of the tumour microenvironment of colorectal cancer
... We have introduced a novel method for analysing multiplex image data such as the TIS image data in Chapter 3. It is dierent from previously presented methods in that it considers the samples at cell rather than at pixel ...
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The relationship between tumour budding, the tumour microenvironment and survival in patients with primary operable colorectal cancer
... selected. Tumour sections were scanned using a Hamamatsu Nano Zoomer (Welwyn Garden City, UK) at 20 magnification, and visualisation was carried out using the Slide path Digital Image Hub, version ...of ...
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Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy
... and CRC [ 181 ]. Multiple trials investigating the effect of metformin as monotherapy and in combination with chemotherapy or TKI therapy are underway (e.g., NCT03137186, NCT01243385). However, there are doubts on ...
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A review on the interactions between the tumour microenvironment and androgen receptor signaling in prostate cancer
... prostate tumour growth in vitro and in vivo, in a phase II study this monotherapy was not successful due to its anti-apoptotic effects and role in the development of enzalutamide resistance ...a tumour ...
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Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour model
... ABSTRACT Despite the availability of recently developed chemotherapy regimens, survival times for pancreatic cancer patients remain poor. These patients also respond poorly to immune checkpoint blockade therapies ...
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