The viral capsid
Retargeting of Rat Parvovirus H-1PV to Cancer Cells through Genetic Engineering of the Viral Capsid
... viral capsid. In the absence of structural data, we modeled the H-1PV capsid based on its homol- ogy with the capsid of the closely related MVM, whose crystal structure has been resolved and ...
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Cellular origin of the viral capsid-like bacterial microcompartments
... resemble viral capsids, but encapsulate enzymes that perform various specialized biochemical reactions in the cell ...minor capsid proteins of viruses, ...known capsid proteins, rendering the origins ...
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Targeting of Adenovirus via Genetic Modification of the Viral Capsid Combined with a Protein Bridge
... molecule. We sought to avoid such a structural problem by extending Cd away from the knob. The length of the linkers in these constructs was 5, 20, or 40 amino acid residues. The fiber-Cd genes were assembled in the ...
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Complementation of a Deletion in the Rubella Virus P150 Nonstructural Protein by the Viral Capsid Protein
... 3, were made in the C-GFP fusion protein cassette, in which the complete C gene is fused with GFP, and the mutated cassettes were introduced into (i) RUBrep/GFP to ascertain replication [r] ...
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The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein
... ZIKV capsid in a proteasome- dependent ...ZIKV capsid to degrade UPF1 could disrupt its normal protea- somal activity and further contribute to the cytopathic effects associated with ZIKV ...the ...
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Characterization of a major protein with a molecular weight of 160,000 associated with the viral capsid of Epstein-Barr virus.
... A monoclonal antibody designated V3 was produced against a late protein associated with the Epstein-Barr virus-induced viral capsid antigen complex.. The antibody reacted with discrete p[r] ...
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Circovirus Transport Proceeds via Direct Interaction of the Cytoplasmic Dynein IC1 Subunit with the Viral Capsid Protein
... Incoming viral particles hijack the intracellular trafficking machinery of the host in order to migrate from the cell surface to the replication ...circovirus capsid subunit enhances microtubular ...
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The Requirement for Nucleoporin NUP153 during Human Immunodeficiency Virus Type 1 Infection Is Determined by the Viral Capsid
... matrix, capsid, or integrase became less sensitive when the latter two elements were ...Two capsid missense mutant viruses, N74D and P90A, were largely insensitive to NUP153 depletion, as was wild-type ...
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Retrovirus Restriction by TRIM5 Proteins Requires Recognition of Only a Small Fraction of Viral Capsid Subunits
... retrovirus capsid. TRIM5 proteins are dimeric, and their association with the viral capsid appears to be enhanced by avidity effects owing to formation of higher-order oligomeric ...to capsid ...
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The highly polymorphic cyclophilin A binding loop in HIV 1 capsid modulates viral resistance to MxB
... of viral capsid with CypA which acts as a host dependency factor for HIV-1, there is a cost for the virus to adopt this MxB-resistant pathway, which helps to explain why these MxB-resistant mutations have ...
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Synthesis and characterization of different immunogenic viral nanoconstructs from rotavirus VP6 inner capsid protein
... the viral capsid protein in the native form with relatively simple, rapid, and economical procedures – opens a new route toward large-scale production of a more efficient antigenic compound to be used as a ...
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Expandohedra: Modeling Structural Transitions of a Viral Capsid
... a capsid (viral protein ...the capsid, which encapsulates the viral genomic material. Viral capsids are a fascinating example of symmetry in nature: in fact, a significant number of ...
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Structural transitions during the scaffolding driven assembly of a viral capsid
... Discussion The conserved assembly pathway of icosahedral capsids from the tailed phages-herpesviruses lineage is characterised by dramatic rearrangements during transition from their initial procapsid state to the final ...
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Quantum dot-induced viral capsid assembling in dissociation buffer
... major capsid protein VP1 into VNPs in dissociation buffer, whereas in previous studies the SV40 capsids encapsulated QDs in assembly ...regular viral capsids when there are QDs in the dissociation buffer ...
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Phosphorylation of the Brome Mosaic Virus Capsid Regulates the Timing of Viral Infection
... ABSTRACT The four brome mosaic virus (BMV) RNAs (RNA1 to RNA4) are encapsidated in three distinct virions that have different disas- sembly rates in infection. The mechanism for the differential release of BMV RNAs from ...
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An HIV 1 capsid binding protein TRIM11 accelerates viral uncoating
... reduces viral reverse transcrip- tion indicated by the fate-of-capsid assay and quantitative PCR ...HIV-1 capsid stability and increased viral reverse ...bearing capsid G89V showed ...
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Enterovirus 71 viral capsid protein linear epitopes: Identification and characterization
... developed an EV71/Cox A16-bispecific MAb using VP1 of EV71, which successfully improved a high-qual- ity EV identification kit, and could be used as a diag- nostic tool for identifying a wide range of EVs isolated from ...
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Herpesvirus Capsid Association with the Nuclear Pore Complex and Viral DNA Release Involve the Nucleoporin CAN/Nup214 and the Capsid Protein pUL25
... the viral genome into the nucleus and to provide a quantitative assay, we used another HSV-1 recombinant vi- rus, tsK/Luci (provided by ...the viral cycle is ...affecting capsid docking and DNA ...
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Human Cytomegalovirus pUL47 Modulates Tegumentation and Capsid Accumulation at the Viral Assembly Complex
... of viral morphogenesis and immunofluorescence revealed that pUL47 is involved in the processes of tegumentation, proper cap- sid trafficking, and their trapping at the vAC, resulting in the ac- cumulation of ...
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Rubella Virus Capsid Protein Modulates Viral Genome Replication and Virus Infectivity
... GFP_6512ⴱ were not (Fig. 2B). Note that the RNA of RUBrep/GFP_⌬NotI migrated faster than that of RUBrep/ GFP because of the deletion in NSP coding region. In the absence of SP genes, no full-length RNA species was ...
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