the Warburg effect
Nuclear Receptors and the Warburg effect in cancer
... The Warburg effect—A metabolic shift Production of ATP via “fermentation” as described by Otto Warburg, (now termed aerobic glycolysis) is a key feature of many cancer ...the Warburg ...
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Fructose contributes to the Warburg effect for cancer growth
... the Warburg effect to preferentially downregulate mitochondrial respiration and increases aerobic glycolysis that may aid metastases that initially have low oxygen ...
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Anaplerosis in cancer: Another step beyond the warburg effect
... “Warburg effect” hypothesis and unveil a complex scenario where energy metabolism in cancer goes beyond a simple interplay between glycolysis and ...
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The Warburg effect then and now: From cancer to inflammatory diseases
... Abstract Inflammatory immune cells, when activated, display much the same metabolic profile as a glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation towards aerobic glycolysis, ...
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Cancer proliferation and therapy: the Warburg effect and quantum metabolism
... In OxPhos, the coupling is electrical and the metabolic rate is determined by the flow of protons across the mitochondrial inner membrane. In glycolysis, the coupling is che- mical and the metabolic rate is regulated by ...
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
... The excess generation of lactate that accompanies the Warburg effect would appear to be an inefficient use of cellular resources. Each lactate excreted from the cell wastes three carbons that might ...
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Amyloid beta resistance and the Warburg effect: Re-examining Alzheimer's disease
... the Warburg effect and increase glucose uptake to protect against A ...the Warburg effect in AD mice is necessary to offer more insight into the metabolic state of affected ...
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PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors
... The expression levels of miR-1 and -133b were relatively high in colon tissue except muscle and very frequently down-regulated in 75 clinical colorectal tumors samples, even in adenomas, compared with those of the ...
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RRAD inhibits the Warburg effect through negative regulation of the NF-κB signaling
... the Warburg effect, indicating that down-regulation of RRAD expression is an important mechanism contributing to the Warburg effect in lung ...the Warburg effect remains ...the ...
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<p>RRAD suppresses the Warburg effect by downregulating ACTG1 in hepatocellular carcinoma</p>
... Finally, we have shown that RRAD is linked to glucose metabolism in HCC cells by downregulating GLUT1, which initiates glycolysis by increasing glucose import into the cytoplasm. 34 The results indicated that ACTG1 may ...
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Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized 13C-MRSI
... the Warburg effect-one of the hallmarks of tumors-can be measured non-invasively with this emerging ...the effect of varying tumor cellularity on image-derived metabolic ...
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Cyclin G2 Inhibits the Warburg Effect and Tumour Progression by Suppressing LDHA Phosphorylation in Glioma
... the Warburg effect and tumour growth by regulating NADH/NAD+ redox homeostasis, which could account for the enhanced lactate production in cancer cells [24, ...
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Expression and phosphorylation of the AS160_v2 splice variant supports GLUT4 activation and the Warburg effect in multiple myeloma
... The purpose of this study was to investigate the molecular basis of constitutive GLUT4 plasma membrane localization in MM cells. Findings: We have elucidated a novel mechanism through which myeloma cells achieve ...
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PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation
... the Warburg effect 1,2 , allows dividing cells to use intermediary glucose metabolites to generate reducing equivalents (such as NADPH) and macromolecules (such as nucleotides, proteins and lipids) required ...
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MicroRNA-29B (mir-29b) regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
... cgi?acc=GSE5846; and GSE26375, http://www.ncbi. nlm.nih.gov/geo/query/acc.cgi?acc=GSE26375). As demonstrated in Figure 4B, none of the four selected glycolytic genes was significantly correlated with miR- 29b expression ...
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STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect
... To investigate the mechanisms by which STAT1 confers an aggressive tumour phenotype, we characterized the down- stream pathways regulated by STAT1. To this end, we gen- erated a stable STAT1 knockdown (KD) in SCC61, a ...
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Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer
... curative resection of hepatocellular carcinoma [28]. Here we reported that wild-type IDH2 is highly expressed in multiple cancers, especially in lung cancer, and this high level of IDH2 correlates with poor survival. We ...
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Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation
... Keywords: Warburg effect, pyruvate dehydrogenase, Src, reactive oxygen species, chemoresistance Received: September 07, 2015 Accepted: January 23, 2016 Published: February 03, 2016 ABSTRACT The ...
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Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers
... INTRODUCTION Relative to normal cells, cancer cells are highly proliferative and thus require increased ATP to meet their metabolic demand. Cancer cells fulfill this requirement by depending on a faster mode of energy ...
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Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis
... Furthermore, autophagy inhibition in osteosarcoma cancer stem cells decreased cancer cell surface markers and enhanced sensitivity to hypoxic conditions and exposure to cisplatin, result[r] ...
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