theranostic agents
Next Generation Theranostic Agents Based on Polyelectrolyte Microcapsules Encoded with Semiconductor Nanocrystals: Development and Functional Characterization
... The factors listed above also affect the morphology of the resultant microcapsules, including their porosity and shape and the integrity of the wall. For example, an increase in the ionic strength or pH of the ...
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uPAR-targeted Optical Imaging Contrasts as Theranostic Agents for Tumor Margin Detection
... uPAR-targeted theranostic nanoparticles, residual tumors were detectable by optical imaging through the imaging contrasts produced by NIR-dye-labeled theranostic nanoparticles in drug resistant tumor ...and ...
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Past, Present, and Future: Development of Theranostic Agents Targeting Carbonic Anhydrase IX
... been proposed for use in adjuvant setting with vascular endothelial growth factor receptor tyrosine kinase inhibitors [100], assuming that myelotoxicity associated with RIT can be safely mitigated or controlled. Several ...
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Polyetherimide-grafted Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub> nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging
... Abstract: Engineering a safe and high-efficiency delivery system for efficient RNA interference is critical for successful gene therapy. In this study, we designed a novel nanocarrier system of polyethyleneimine ...
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Folic acid-functionalized polyethylenimine superparamagnetic iron oxide nanoparticles as theranostic agents for magnetic resonance imaging and PD-L1 siRNA delivery for gastric cancer
... We synthesized and characterized a gene-delivery system based on SPIONs encapsulated with FA-PEG-SS-PEI polymer and successfully delivered PD-L1 siRNA into SGC-7901 cells. The FA-PEG-SS-PEI-SPION/siRNA polyplex exhibited ...
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The Many Spaces of uPAR: Delivery of Theranostic Agents and Nanobins to Multiple Tumor Compartments through a Single Target
... inhibitory agents suggests that the development of these uPA inhibitors may parallel the difficulties found in the development of ma- trix-metalloprotease (MMP) inhibitors [12, ...
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Small molecules as theranostic agents in cancer immunology
... immune theranostic effect, 1) both intracellular signal pathways down/upstream of immune checkpoints and related therapeutic agents need to be explored; 2) new imaging techniques such as quantum-inspired ...
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Gold nanorods/mesoporous silica-based nanocomposite as theranostic agents for targeting near-infrared imaging and photothermal therapy induced with laser
... a theranostic nanocomposite could realize the combination of GNRs-based photothermal ablation under NIR illumination, ICG-mediated fluorescent imaging, and tLyp-1-enabled more easy endocytosis into breast cancer ...
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Porphyrins as Theranostic Agents from Prehistoric to Modern Times
... operation from one of the earliest recorded medical textbooks, illustrating how visual detection of blood has long provided optical feedback for guiding med- ical procedures. The evolutionary importance of heme is ...
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Trackable and Targeted Phage as Positron Emission Tomography (PET) Agent for Cancer Imaging
... While theranostic approach has become an at- tractive strategy for in vivo cancer imaging and ther- apy studies, there is a significant shortage of estab- lished platforms/methods for biodegradable ...
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Theranostic applications of nanoparticles in neurodegenerative disorders
... system. Theranostic strategies are known to combine therapeutic and diagnostic capabilities ...developing theranostic agents that can be used as an efficient nano-carrier ...effective ...
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Gadolinium-Chelated Conjugated Polymer-Based Nanotheranostics for Photoacoustic/Magnetic Resonance/NIR-II Fluorescence Imaging-Guided Cancer Photothermal Therapy
... NIR-II agents featured with strong NIR absorption can also function as photoacoustic (PA) agents for PA imaging (PAI) and PTT [28, ...PTT theranostic agents based organic materials for ...
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Preparation, Characterization, Cytotoxicity and Biological Evaluation of 99mTc-Doxorubicin-Epigallocatechingallate Functionalized Gold Nanoparticles as a New Generation of Theranostic Radiopharmaceutical
... therapeutic agents thus making functionalized AuNPs as multiplexed therapeutic agents ...contrast agents thus opening up new opportunities in the utility of functionalized AuNPs as theranostic ...
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Artesunate Loaded and Near Infrared Dye Conjugated Albumin Nanoparticles as High Efficiency Tumor Targeted Photo Chemo Theranostic Agent
... multifunctional theranostic agent was synthetized using a facile method, combining four clinically approved materials: artesunate (Arte), human serum albumin (HSA), folic acid (FA), and indocyanine green ...
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Theranostic liposomes loaded with quantum dots and apomorphine for brain targeting and bioimaging
... Abstract: Quantum dots (QDs) and apomorphine were incorporated into liposomes to eliminate uptake by the liver and enhance brain targeting. We describe the preparation, physicochemical characterization, in vivo ...
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Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation
... therapeutic agents is of highest interest, with the caveat that untoward side effects can occur because of the wide spectrum of identified BACE1 substrates, especially in the central nervous system ...
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Copper-64: a real theranostic agent
... Malignant tissues have been characterized as having higher levels of Cu accumulation, and this observa- tion is consistent with the overexpression of human copper transporter 1 (hCTR1)[r] ...
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Theranostics and contrast agents for magnetic resonance imaging
... and artery disease [48, 49]. There is a need for targeted and effective CAs to allow noninvasive imaging of the cholesterol-rich atherosclerotic plaques in arteries [50]. High-density lipoprotein (HDL) based CA is one of ...
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Dual Somatostatin Receptor/FDG PET/CT Imaging in Metastatic Neuroendocrine Tumours: Proposal for a Novel Grading Scheme with Prognostic Significance
... With the increasing recognition of the role of nuclear medicine in NET imaging and therapy, a so-called “theranostic” paradigm, and the need for accurate prognostic tools, we devised a novel scheme for dual ...
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Theranostic DNAzymes
... conjugate DNAzymes to various nanomaterials for signaling and delivery. Finally, compared to RNA and proteins, DNA is much more stable and cost-effective. The first DNAzyme was reported in 1994 for RNA cleavage [10]. ...
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