Therapeutic target
The glycocalyx: a novel diagnostic and therapeutic target in sepsis
... In the healthy state, the glycocalyx serves as a barrier opposing vascular permeability, in part by serving as a negatively charged molecular sieve [3]. This “meshwork” limits transvascular movement of negatively charged ...
12
Sgo1 is a potential therapeutic target for hepatocellular carcinoma
... The idea of targeting cancer cells through the activation of spindle assembly checkpoint is being actively exploited. Vinca alkaloids block microtubule polymerization and thereby prevent the formation of a proper spindle ...
11
Nucleo-cytoplasmic transport as a therapeutic target of cancer
... Shuttling of specific proteins out of the nucleus is essential for the regulation of the cell cycle and proliferation of both normal and malignant tissues. Dysregulation of this fundamental process may affect many other ...
9
MYC as therapeutic target in leukemia and lymphoma
... Abstract: MYC is a transcription factor that is involved in the expression of many genes. Deregulated MYC is found in about half of human tumors, being more prevalent in hematologi- cal neoplasms. Deregulation mechanisms ...
17
SALL4 is anovel therapeutic target in intrahepatic cholangiocarcinoma
... Intrahepatic cholangiocarcinoma (ICC) is the most common and deadly disease of the biliary tree due to its poor prognosis. Sal-like protein 4 (SALL4), a stem cell marker, has been identified as a potential target ...
11
Is the inflammasome a potential therapeutic target in renal disease?
... The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury. Pattern recognition receptors that are either membrane bound or cytoplasmic ...
13
Enolase-1 is a therapeutic target in endometrial carcinoma
... In order to further validate the role of ENO1 and its molecular basis in EC, we evaluated the expression of ENO1 in human normal endometrium (NE) and EC tissues, as well as its effects on cell glycolysis, growth, ...
18
Phosphatase and tensin homologue: a therapeutic target for SMA
... UPS target protein in SMA patients due to dysregulation of UPS/ UBA1 pathway 46 suggesting UBA1 as an important and potentially attractive therapeutic target for ...
7
MAP4K4: an emerging therapeutic target in cancer
... The serine/threonine kinase MAP4K4 is a member of the Ste20p (sterile 20 protein) family. MAP4K4 was initially discov- ered in 1995 as a key kinase in the mating pathway in Saccharomyces cerevisiae and was later found to ...
9
KDM1 is a novel therapeutic target for the treatment of gliomas
... p53 target genes p21 and ...p53 target genes (p21 and PUMA), leading to apoptosis of glioma xenograft ...potential therapeutic target for the treatment of ...
11
Molecular Chaperone Hsp90 Is a Therapeutic Target for Noroviruses
... Human noroviruses (HuNoV) are a significant cause of acute gastroenteritis in the developed world, and yet our understanding of the molecular pathways involved in norovirus replication and pathogenesis has been limited ...
12
HOTAIR is a therapeutic target in glioblastoma
... Figure 6B). In vivo bioluminescence imagingindicated that the volume of tumors derived from HOTAIR-depleted cells was decreased compared with tumors derived from control cells in both cell lines (80% reduction in U87 ...
13
Linking rare and common disease: mapping clinical disease-phenotypes to ontologies in therapeutic target validation
... for Therapeutic Target Validation (CTTV - ...generate therapeutic target evidence from genome-scale experiments and ...of therapeutic targets by integrating existing and newly-generated ...
11
SGEF is a potential prognostic and therapeutic target for lung adenocarcinoma
... LAC is currently the major histological subtype of lung cancer, and the average of 5-year survival rate was only 15% [10], owing to the invasion and metastasis. Thus, searching for specific invasive therapeutic ...
7
ApoE4: an emerging therapeutic target for Alzheimer’s disease
... apoE4-related therapeutic target; this calls for further translational studies directed at the development of novel and druggable brain permeating activators of ...
17
BCL-2 as therapeutic target for hematological malignancies
... relevant target for therapy for many diseases, including solid tumors and hematological ...as therapeutic target for hematological malignancies, and the results obtained with selective inhibitors ...
15
Liver X Receptor: A novel therapeutic target
... UCP-l is a target gene of LXR. Leptin and UCP-1 expression was downregulated after administration of an LXR agonist. So decreased leptin levels would eventually lead to increased energy intake and decreased UCP-l ...
10
HER2 as a novel therapeutic target for cervical cancer
... To date, we can find only one clinical study in cervical cancer patients to evaluate the therapeutic effects of anti-HER2/neu therapy. Monk et al. reported that only pazopanib alone improved progression-free ...
12
B cells as a therapeutic target in autoimmune disease
... The question of which patients with RA respond to anti- CD20 treatment and whether the response is transient or long-term is directly linked to the role of B cells in the pathogenesis of RA [23,24]. One obvious ...
5
Ceramides: a potential therapeutic target in pulmonary emphysema
... Sphingolactone has previ- ously shown to ameliorate LPS-induced acute lung in- jury in mice by inhibiting neutral sphingomyelinase, thereby decreasing ceramide levels In the present stud[r] ...
12