therapeutic targets
Therapeutic targets in systemic sclerosis
... The precise aetiology of systemic sclerosis (SSc) remains elusive, but significant advances over the past few years have improved our understanding of the underlying pathogenic processes and identified key pathways and ...
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Advances in the proteomic discovery of novel therapeutic targets in cancer
... pulmonary adenocarcinoma tissues and paired surrounding normal tissue with two-dimensional (2D) gel electrophoresis and ESI-Q-TOF (electrospray ionization, quadrupole, time- of-flight) MS/MS instruments. Thirty-two ...
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Emerging therapeutic targets in esophageal adenocarcinoma
... The incidence of gastro-esophageal disease and associated rate of esophageal adenocarcinoma (EAC) is rising at an exponential rate in the United States. However, research targeting EAC is lagging behind, and much ...
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Subunits of human condensins are potential therapeutic targets for cancers
... novel targets for cancer ...potential therapeutic target for human cancers, and therefore that all subunits of human condensins are potential therapeutic targets for human ...
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Rho GTPases as therapeutic targets in Alzheimer’s disease
... The progress we have made in understanding Alzheimer ’ s disease (AD) pathogenesis has led to the identification of several novel pathways and potential therapeutic targets. Rho GTPases have been implicated ...
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From integrative genomics to therapeutic targets.
... potential therapeutic targets in a candidate driven approach, integrating functional profiling data offers an unbiased way of identifying genetic ...the targets identified ...novel therapeutic ...
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Therapeutic targets for HIV 1 infection in the host proteome
... only therapeutic option available for seropositive and symptomatic individuals, and is com- prised of targeted inhibitors of HIV-1 reverse transcriptase (NNRTIs and NRTIs) and/or protease (PI) and the newly FDA ...
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Novel Therapeutic Targets in the Brain Tumor Microenvironment
... Accumulating data suggest the extracellular HSPGs, and the enzymes that modify them, may regulate ligand-mediated signaling pathways in GBM. Given their role in disease combined with their accessibility in the ...
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Therapeutic targets for bone metastases in breast cancer
... activation of the RANKL/RANK or the Jagged1/Notch signaling pathways. Then, integrin, Src and cathepsin K play an essential role in the bone-resorbing activity of mature osteoclasts. In addition, breast cancer cells ...
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gp130 receptor ligands as potential therapeutic targets for obesity
... new therapeutic options for the treatment of obesity are clearly ...potential therapeutic targets in ...a therapeutic strategy to treat ...
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Inflammasomes as therapeutic targets for Alzheimer's disease
... potential therapeutic targets including caspase-1 activation and signalling at the IL-1R1 ...as therapeutic in AD does not appear ...preferred therapeutic strategy of inflammasome dependent AD ...
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Preclinical evaluation of potential therapeutic targets in dedifferentiated liposarcoma
... The exome analysis did not reveal any good candidate therapeutic targets based on point mutations. However, since many subtypes of sarcomas, and particularly WD/DDLPS, are largely thought to be copy ...
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MicroRNA as therapeutic targets for treatment of depression
... With potentially life-threatening consequences, depression is a major health concern characterized by low mood, anhedonia, disturbance of sleep and appetite, and feel- ings of despair, shame, and guilt. Dysregulation of ...
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PIM kinases as therapeutic targets against advanced melanoma
... novel therapeutic targets for melanoma, we screened a panel of structurally diverse organometallic inhibitors against human-derived normal and melanoma ...that targets PIM kinases (a family of ...
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Many cytokines are very useful therapeutic targets in disease
... therapeutics that address unmet needs. This Review Series surveys three chronic inflammatory disease areas and two forms of cancer and discusses the important role of cytokines and their receptors in these disease ...
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NF-κB and IKK as therapeutic targets in cancer.pdf
... Human cancer is a highly diverse and complex disease based on multiple etiologies, multiple cell targets, and distinct developmental stages. Additionally, cancer cells often exhibit genomic instability, which ...
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Thrombin Structural and Functional Determinants as Therapeutic Targets
... The qualities of an ideal thrombin inhibitor should be an easy route of administration, high efficacy and safety (with minimal contraindications or adverse effects), rapid onset, a therapeutic half- life, minimal ...
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Recent Advances in Therapeutic Targets of Tardive Dyskinesia
... Tardive dyskinesia is a hyperkinetic neurodege- nerative movement disorder which is severe, debi- litate, unrealized and everlasting mainly arises after prolong medication with Dopamine antagon- ist. The pathophysiology ...
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Cystic fibrosis: current therapeutic targets and future approaches
... Key findings: Cystic fibrosis is an autosomal recessive disorder due to mutations in CFTR gene leading to abnormal- ity of chloride channels in mucus and sweat producing cells. Respiratory system and GIT are primarily ...
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“Molecular Docking Studies of Xanthium indicum Bioactive Compounds with Therapeutic Targets of Diabetes Mellitus” by Meruva Anila Devi, Ganjikunta Venkata Subbaiah, Kesireddy Sathyavelu Reddy, India.
... molecular targets of diabetes like Glucokinase, Fructose 1, 6- bisphosphatase, Human multidrug resistance protein 1, G- protein activated inward rectifier potassium channel 3, Human mitochondrial ABC transporter, ...
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