Thiadiazole derivatives
SYNTHESIS OF PHARMACEUTICALLY IMPORTANT 1, 3, 4 THIADIAZOLE DERIVATIVES AS ANALGESIC AND ANTIPYRETIC AGENTS
... A series of novel 1, 3, 4-Thiadiazole derivatives were synthesized and the structure of the entire compounds were confirmed by recording by their 1 H NMR, and IR spectra. In conclusion, we feel that the ...
22
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL 1, 3, 4-THIADIAZOLE DERIVATIVES
... The compounds were tested in vitro for their antimicrobial activity against seven microorganisms belonging to bacteria and fungi classes. The antimicrobial activity was done at 40µg/ml concentration by cup and plate ...
6
SYNTHESIS AND CHARACTERIZATION OF NOVEL 1, 3, 4- THIADIAZOLE DERIVATIVES AND SCREENING FOR CERTAIN BIOLOGICAL ACTIVITIES
... phenyl(PM8) 2-methyl phenyl(PM9) derivatives do not have any α- amylase inhibitory activity. α amylase inhibitors are also called as starch blockers since it prevents or slows the absorption of starch into the ...
10
Synthesis, Characterization and Biological activity of 1,3,4- Oxadiazole and 1,3,4- Thiadiazole Derivatives.
... 2-amino-5-substituted1,3,4- thiadiazole respectively were undergoes mannich reaction with substituted aniline and formaldehyde to get mannich base 2-amino 5-substituted 1,3,4-oxadiazole derivatives and 2- ...
180
5-(Thiophen-2-yl)-1,3,4-thiadiazole derivatives: synthesis, molecular docking and in vitro cytotoxicity evaluation as potential anticancer agents
... 1,3,4-thiadiazole derivatives were synthesized and investigated for their in vitro antitumor activity against human lung cancer cell lines and human hepatocellular carcinoma cell lines, and the results ...
13
Synthesis and antibacterial activity study of some new 1,3,4-thiadiazole derivatives
... A series of 2-amino-substituted-5-phenyl-1,3,4-Thiadiazole derivatives was synthesized with good yields and their structures were elucidated by spectral data. Compounds 7e and 7f exhibited good ...
5
A Convenient route for the synthesis of antimicrobial 1, 3, 4- thiadiazole derivatives
... 4- thiadiazole derivatives are also known to exhibit diverse biological properties like antimicrobial [9,10] , antitubercular[11,12] , anti-inflammatory[13] and ...benzothiozole derivatives linked ...
6
SYNTHESIS AND CHARACTERIZATION OF A SERIES OF NOVEL SCHIFFS’ BASES OF 1, 3, 4 THIADIAZOLE DERIVATIVES
... Literature review showed that 1, 3, 4- Thiadiazole and its derivatives possess wide range of therapeutic effectiveness. In addition, Schiffs’ bases also possess broad spectrum anticancer, antibacterial, ...
7
Synthesis and Antimicrobial Activity of Some New [1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazole Derivatives
... b][1,3,4]thiadiazole derivatives and their antibacterial and antifungal ...[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives has good antibacterial activity against all strains but only few ...
6
Synthesis, characterization and antimicrobial activity of new 2,5 disubstituted 1,3,4 thiadiazole derivatives
... 2,5-di-mercapto-1,3,4-thiadiazole derivatives were successfully prepared and tested for their antimicrobial ...produced derivatives show moderate to good activity against the bacterial and fungal ...
11
Synthesis and biological evaluation of some novel triazolo, thiadiazole derivatives of gallic acid
... 459 Arun K Subramani etal Der Pharma Chemica; 2009, 1 (1) 70 77 70 Synthesis and biological evaluation of some novel triazolo, thiadiazole derivatives of gallic acid Arunkumar Subramani * a, Ilango Ka[.] ...
8
Review Article on Synthesis of 1,3,4 Thiadiazole Derivatives and It’s Biological Activity
... S Geogeta [12] has reported the synthesis of 2-R-5-formyl-1,3,4-thiadiazole derivatives. The aromatic and heterocyclic amines after treatment with carbon disulfide in ammonium hydroxide followed by ...
13
SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEW 1,3,4- THIADIAZOLE DERIVATIVES FOR THEIR ANTIMICROBIAL ACTIVITIES
... All the newly synthesized 1, 3, 4-thiadiazole derivatives were screened for their antibacterial and antifungal activity. For antibacterial studies microorganisms employed were Staphylococcus aureus ATCC ...
6
SYNTHESIS AND CHARACTERISATION OF SOME THIADIAZOLE DERIVATIVES
... Porphobilinogen, a trisubstituted pyrrole, is the biosynthetic precursor to many natural products such as heme. Pyrroles are components of more complex macrocycles, including the porphyrins of heme, the chlorins, ...
8
SYNTHESIS AND EVALUATION OF THIADIAZOLE DERIVATIVES
... 4,-thiadiazole derivatives are important precursors for the synthesis of many bioactive molecules belonging to various therapeutic categories such as anti microbial, anti fungal, anti cancer, anti ...
8
Synthesis and Characterization of Novel 1,3-Thiazole and 2-Amino-1,3,4-Thiadiazole Derivatives
... Thiosemicarbazone derivatives 3a–e were synthesized by the reaction of various aldehydes 1a–e with 4-methyl thiosemicarbazide 2 in 78% to 90% ...thiosemicarbazone derivatives 3a–e with ...
10
PHARMACOLOGICAL ACTIVITY OF 1,3,4-THIADIAZOLE DERIVATIVES AND ITS COMPLEXES: A REVIEW
... The metal complexes of Mn(II), Fe(II), Ni(II) and Cu(II) with Schiff bases of 5-acetamido-1,3,4-thiadiazole-2-sulphonamide (Fig.13) were screened against Aspergillus niger and A. flavus. The ligands presented here ...
8
DESIGN AND MOLECULAR DOCKING STUDIES OF SOME 1,3,4 THIADIAZOLE DERIVATIVES
... INTRODUCTION: 1,3,4-Thiadiazole have wide spectrum of biological activities including anticonvulsant activity. In addition to presently available anticonvulsant drugs viz. There is need to develop such new ...
8
Synthesis, Characterization and Biological screening of novel 2,5-disubstituted-1,3,4-thiadiazole derivatives
... The varied biological activities of 1,3,4-thiadiaoles and their analogs have been known from the beginning of the 20 th century [8, 9]. Literature survey revealed that slight modification in the structure can result in ...
15
SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 1,3,4-THIADIAZOLE DERIVATIVES: A REVIEW
... b][1,3,4]thiadiazoles 18(a—j). All the synthesized compounds were tested for in vitro activities against certain strains of bacteria such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and fungi such as ...
13