thiazolidine-2
THIAZOLIDINE-2,4-DIONES: AN UPDATE REVIEW OF ANTIDIABETIC AGENTS
... 5-[[4-[2-(1-indolyl)ethoxy]phenyl]methyl] thiazolidine-2,4-dione (21) was selected for further evaluation studies at different doses level in db/db and ob/ob ...
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DESIGN AND SYNTHESIS OF BENZYLIDENE THIAZOLIDINE 2, 4 DIONE DERIVATIVES WITH THEIR ANTICANCER AND ANTIDIABETIC BIOLOGIAL SCREENING
... benzylidene thiazolidine-2, 4-dione derivatives synthesized using 5-(4- hydroxybenzylidene) thiazolidine-2, 4-dione and their biological evaluation as anticancer and antidiabetic agents ...
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In Silico Designing of Novel Thiazolidine-2-one Derivatives as Dual PDE4/7 Inhibitors for Inflammatory Disorders
... substituted thiazolidine-2-one derivatives as dual inhibitors of PDE4/7 using structure based rational drug design ...of thiazolidine-2-one analogues were designed and molecular docking was ...
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QSAR study on thiazolidine-2,4-dione derivatives for antihyperglycemic activity
... various thiazolidine-2,4-diones attempts to address this need by arriving at the physico-chemical properties required for high antihyperglycemic activity in the form of a mathematical equation, according to the ...
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Synthesis, Physical characterisation and Biological Evaluation of novel 1, 3- thiazolidine-2, 4-dione derivatives as ALR-2 inhibitors
... activity thiazolidine-2,4- diones derivatives found to have diverse pharmacological actions like anti-inflammatory, anti-microbial, anti-proliferative, antiviral, anticonvulsant, anti-cancer ...
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SYNTHESIS AND ANTIDIABETIC EVALUATION OF SOME THIAZOLIDINE 2, 4 DIONE DERIVATIVES
... type 2 diabetes mellitus (Type 2 DM) are characterized by tissue resistance to the effects of insulin secreted by pancreatic beta ...new Thiazolidine-2, 4-diones such as pioglitazone, ...
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SYNTHESIS, MOLECULAR DOCKING STUDIES AND BIOLOGICAL EVALUATION OF 5-[4-(SUBSTITUTED) BENZYLIDENE OR BENZYL] THIAZOLIDINE-2, 4-DIONE WITH THEIR ORAL HYPOGLYCEMIC ACTIVITY
... benzyl] thiazolidine-2, 4-dione (TZDs) have been synthesized using economical synthetic ...benzylidene] thiazolidine-2, 4-dione and 5-[4-(2-amino-5-ethoxypyridine) ethoxy benzyl] ...
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Synthesis, SAR and in vitro therapeutic potentials of thiazolidine-2,4-diones
... Conclusion: All the synthesized derivatives exhibited good antimicrobial, antidiabetic and antioxidant activities using specific methods then compared with mentioned standard drugs. Especially, compounds 3, 4, 9, 10, 12 ...
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SOLID-SUPPORTED CATALYSED GREEN SYNTHESIS OF THIAZOLIDINEDIONE DERIVATIVES AND ITS BIOLOGICAL SCREENING
... TLC showed completion of the reaction, ethanol was added to the solid mass, with stirring and the catalyst was filtered off. The residue was then washed with ethanol. The filtrate was evaporated on water bath and then ...
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SYNTHESIS, ANTITUBERCULAR EVALUATION AND DOCKING STUDIES OF NOVEL BENZIMIDAZOLE ANALOGUES
... CONCLUSION: A series of (Z)-3-((1H-benzo[d] imidazol-2-yl) methyl)-substituted thiazolidine-2,4- dione derivatives (9a-n) have been synthesized. The structural elucidation of synthesized compounds was ...
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Synthesis and Biological Evaluation of Some New Rhodanine Analogues as Aldose Reductase Inhibitors (ARIs)
... to thiazolidine-2,4-dione and 2- iminothiazolidine-4-one that include an oxo or imino group, respectively, instead of the thioxo group at position ...
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SYNTHESIS AND EVALUATION OF NOVEL THIAZOLIDINEDIONE DERIVATIVES FOR ANTIDIABETIC ACTIVITY
... type 2 is characterized by insulin resistance or reduced insulin ...compounds thiazolidine-2, 4- diones (TZDs) which act as insulin sensitivity enhancers 2 ...
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Crystal structure of [3 (4,5 dihydro 1,3 thiazolin 2 yl κN) 1,3 thiazolidine 2 thione κS2](1,3 thiazolidine 2 thione κS2)copper(I) nitrate
... anions could function as simple counter-ions to balance the charge on the metal or alternatively act as a ligand to the metal ion (Ferrer et al., 2000; Pal et al., 2005; Khavasi et al., 2011). However, the tzdSH ligand ...
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Synthesis and Characterization of Some New Imidazo [2,1-A] Pyrazolo [3,4-D] Thiazoles as Potentials Fungicide
... The corresponding 2-(p-Ethoxy arylidene)-5,6-hydroimidazol [2,1-a] thiazolidine - 3-ones were synthesized by condensation of 2- mercapto imidazolene. Pyridine and ethyl chloroacetate in dry ethanol ...
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Title: A REVIEW ON HERBAL MEDICINAL PLANTS FOR THE TREATMENT OF OBESITY Author: Neeraj Kumar Sharma*, Dheeraj Ahirwar Keyword: Obesity, Herbal medicines, lipid lowering, anti-obesityPage No: 1-33Download PDF
... of 2-alkyl, 3- arylideneamino-4- quinazolinones with thioglycolic acid and chloroacetyl chloride ...Synthesized 2- (3,5-di-tert- butyl-4-hydroxy phenyl)-3- (3-N- methyl- (2,3,4- methylenedioxy)- phenyl- ...
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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF IN VITRO CYTOTOXIC, ANTIBACTERIAL, ANTIOXIDANT ACTIVITY AND MOLECULAR DOCKING STUDIES OF NITRO SUBSTITUTED BENZOXAZOLE LINKED THIAZOLIDINE DERIVATIVES
... The Schiff’s base 5(a–j) were treated with thioacetic acid and pinch of zinc chloride in presence of dioxane as solvent to forms thioazolidinone derivatives 6(a–j) (Scheme 2). The target molecules were confirmed ...
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Palladium-unleashed proteins: gentle aldehyde decaging for site-selective protein modification
... chloride dimer 16 induced precipitation of GFP seemed unusual given its successful use for other types of decaging with GFP. 36 Subsequently, further screening using this palladium source showed that at concentrations ...
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Crystal structures of two substituted thiazolidine derivatives
... Both compounds were obtained through a similar procedure. To a solution of acenaphthoquinone (1.0 mmol) and thia- zolidine-4-carboxylic acid (1.5 mmol) in dry toluene, were added under nitrogen atmosphere ...
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Title: EVALUATION OF ANTI-DIARRHOEAL ACTIVITY OF HYDRO-ALCOHOLIC LEAF EXTRACT OF PHLOGACANTHUS THYRSIFLORUS IN ALBINO WISTAR RATS Author: Ashish K.Paharia, Dr. A.Pandurangan Keyword: Antidiarrhoeal Activity, Phlogacanthus thyrsiflorus Traditional medicine, Castor oil induced diarrhoea, Small intestinal transit, charcoalPage No: 145-150Download PDF
... A series of paracetamol contending 4-oxo- thiazolidine derivatives (2a-2l) were synthesized and characterized by analytical and spectral studies. The newly synthesized compounds were evaluated for antibacterial ...
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SYNTHESIS, CHARACTERISATION AND BIOLOGICAL EVALUATION OF HETEROCYCLES CONTAINING BISTHIAZOLIDINE RING USING HALOVINYL ALDEHYDES
... Ca 2+ channel blocker [29] , cardio protective [30] ...of thiazolidine has attracted the attention of many researchers to explore its multiple potential against several ...
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