THIAZOLIDINE DERIVATIVES
SYNTHESIS OF SOME NOVEL THIAZOLIDINE DERIVATIVES WITH BENZOTHIAZOLE MOIETY
... several thiazolidine derivatives in the development phase as potential new ...the thiazolidine skeleton, in addition to its relative chemical simplicity and accessibility, makes these chemicals ...
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Synthesis of 2 substituted aryl 4 oxo 1,3 thiazolidine derivatives of indole : a new class of biological active compounds
... Our synthesis strategy was based on to synthesize a highly biologically active heterocycle containing indole and thiazolidine moieties. As the results, we obtained a series of thiazolidine ...
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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF IN VITRO CYTOTOXIC, ANTIBACTERIAL, ANTIOXIDANT ACTIVITY AND MOLECULAR DOCKING STUDIES OF NITRO SUBSTITUTED BENZOXAZOLE LINKED THIAZOLIDINE DERIVATIVES
... with thiazolidine derivatives were synthesized by the cyclization of substituted Schiff’s base with thioglycolic ...with thiazolidine derivatives 6(a-j) exhibited promising antimicrobial ...
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Identification of Some New Tetrazole and Thiazolidine Derivatives Synthesized From 4-Chlorobenzoic Acid and Evaluation Their Antibacterial Effect
... Thiazolidinones are derivatives of thiazolidine, which is a main pharmacophoric group responsible for anti-diabetic activity. It acts by enhancing insulin sensitivity in both muscle and adipose tissue and ...
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SYNTHESIS AND CHARACTERIZATION OF NOVEL CHROMEN BASED THIAZOLIDINE DERIVATIVES AS MEDICINALLY POTENTIAL AGENTS
... Numerous Chromen derivatives have entire been various biological properties, mainaly as antiviral, anti bacterial, anti fungal, anti inflammatory agents. The 1, 4-dihydro-cyclopenta[c] Chromen ring system is of ...
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7′ (4 Methoxyphenyl)chroman 3 spiro 6′ hexahydro 1H pyrrolo[1,2 c]thiazole 5′ spiro 3′′ 1′′H indole 4,2′′(3′′H) dione
... Thiazolidine derivatives possess antidiabetic and adipogenic properties (Norisada et ...These derivatives induce insulin resis- tance via the normalization of protein-tyrosine phosphatase activities ...
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Crystal structures of two substituted thiazolidine derivatives
... 2011). Thiazolidine derivatives have attracted continuous interest over the years because of their varied biological activities (Shih et ...the thiazolidine ring system derives from the fact that it ...
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Synthesis, characterization and structure activity relationship analysis of Nacetyl 2 substituted phenyl thiazolidine 4 carboxylic acids derivatives as neuraminidase inhibitors
... and thiazolidine derivatives have become especially noteworthy in recent years ...[1,2]. Thiazolidine derivatives has an interesting biological activities, some of these are anticancer ...
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Title: EVALUATION OF ANTI-DIARRHOEAL ACTIVITY OF HYDRO-ALCOHOLIC LEAF EXTRACT OF PHLOGACANTHUS THYRSIFLORUS IN ALBINO WISTAR RATS Author: Ashish K.Paharia, Dr. A.Pandurangan Keyword: Antidiarrhoeal Activity, Phlogacanthus thyrsiflorus Traditional medicine, Castor oil induced diarrhoea, Small intestinal transit, charcoalPage No: 145-150Download PDF
... A series of paracetamol contending 4-oxo- thiazolidine derivatives (2a-2l) were synthesized and characterized by analytical and spectral studies. The newly synthesized compounds were evaluated for ...
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SYNTHESIS, CHARACTERISATION AND BIOLOGICAL EVALUATION OF HETEROCYCLES CONTAINING BISTHIAZOLIDINE RING USING HALOVINYL ALDEHYDES
... synthesized thiazolidine derivatives 7a-d: The synthesized compounds 7a-d were evaluated in-vitro for antimicrobial activity against Staphylococus aureus and Escherichia coli and antifungal activity against ...
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THIAZOLIDINE-2,4-DIONES: AN UPDATE REVIEW OF ANTIDIABETIC AGENTS
... containing thiazolidine-2,4-diones or glitazones are shown better treatment on type 2 diabetes mellitus via acting on peroxisome proliferator-activated receptor-gamma ...
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Design and synthesis of 3 (2 cinnamamidoethylsulfonyl) thiazolidine 4 carboxylate derivatives as novel angiotensin converting enzyme (ACE) inhibitors
... , and a 4-fluorine in position R 3 , showed the most active inhibitory. The hydrogen-bonding between the carboxylate binding the thiazolidine and the enzyme maybe not important because of esterification it ...
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Exploring Aryl Thiazolidine Carboxamides as a New Class of Antimycobacterials
... Sixty four various new 2-aryl thiazolidine-4-carboxamides were synthesized from L-cysteine according to the literature method (Scheme:1). 17 Briefly, Compounds i and ii were reacted in ethanol to obtain the ...
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In vitro Antibacterial Evaluation of Newly Synthesized Heterocyclic Compounds Against Streptococcus Pneumoniae
... other derivatives, on ...thiazole derivatives can prevent bacterial growth through inhibition of enzymatic activities of DNA gyrase (it catalyzes the ATP-dependent negative super- coiling of double-stranded ...
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Crystal structure of [3 (4,5 dihydro 1,3 thiazolin 2 yl κN) 1,3 thiazolidine 2 thione κS2](1,3 thiazolidine 2 thione κS2)copper(I) nitrate
... anions could function as simple counter-ions to balance the charge on the metal or alternatively act as a ligand to the metal ion (Ferrer et al., 2000; Pal et al., 2005; Khavasi et al., 2011). However, the tzdSH ligand ...
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Synthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of nitro-l-arginine methyl ester
... Agar disc diffusion method Antibacterial and antifungal activity of the 6a–j derivatives expressed as diameter of inhibition area was evaluated by the standard disk dif- fusion assay according to described ...
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SWFB and GA Strategies for Variable Selection in QSAR Studies for the Validation of Thiazolidine- 2,4-Dione Derivatives as Promising Antitumor Candidates
... The 2D-QSAR study of 24 compounds (divided into 6 test and 18 training) for anticancer activity through PLS (models 1 and 2) and MLR (models 3 and 4) analysis coupled with SW-FB and GA, variable selection resulted in ...
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Synthesis, Physical characterisation and Biological Evaluation of novel 1, 3- thiazolidine-2, 4-dione derivatives as ALR-2 inhibitors
... activity thiazolidine-2,4- diones derivatives found to have diverse pharmacological actions like anti-inflammatory, anti-microbial, anti-proliferative, antiviral, anticonvulsant, anti-cancer ...
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Synthesis and anticonvulsant activity of new 3’-aryl- 7-bromo-spiro[ [1]benzothiophene-3,2’-[1,3] thiazolidine]-2,4’-dione derivatives
... naphthyl derivatives 5e and 6e were found to be the most effective in prolongation phenobarbitone-induced sleeping time as well as protection against strychnine- induced ...
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Synthesis and Antifungal Evaluation of Barbiturate Saponins And Progress Towards Cysteinyl Metal Peptides
... Although we desire to use L-cysteine HCl for our reaction for selective β-sulfhydryl protection as a free carboxy group is required for metal complexation. But the free carboxy group changes the reaction pH along with ...
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