Thrombin activity
The generation of fibrinopeptide A in clinical blood samples: evidence for thrombin activity
... whereas thrombin addition was without ...increased thrombin activity and was seen in patients with pulmonary embolism, active systemic lupus erythematosus, renal transplant rejection, and after ...
10
Studies on a family with combined functional deficiencies of vitamin K dependent coagulation factors
... of thrombin activity occurred in the patients' plasmas after treatment with nonophysiologic activators that do not require calcium for prothrombin ...
9
Blood Compatibility of Amphiphilic Poly(N α acrylamide L lysine b dimethylsiloxane) Block Copolymers
... of thrombin activity was ...antithrombotic activity can be verified by the enzymatic reaction of thrombin and a synthetic substrate S-2238 in the presence of poly(LysAA-b-DMS)-1-3 as shown in ...
10
Global assays and the management of oral anticoagulation
... or thrombin activity, ...and thrombin inhibitors, but these tests are unsuitable for the assessment of anticoagulation reversal by non-specific prohemostatic agents like prothrombin complex ...
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Defining the Role of Blood-Spinal Cord Barrier Breakdown and Spinal Thrombin Signaling tn the Development of Pain Following Neural Trauma
... Human thrombin that is continuously infused at high concentrations over 7 days into the rat midbrain induces elevated vimentin-positive astrocytes (Nishino et ...Spinal thrombin also has been related to the ...
455
The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective?
... that thrombin also mediates brain injury in human ICH, with perihematomal brain edema being less after systemic treatment with argatroban, a thrombin inhibitor (Hamada et ...although thrombin is ...
7
A Systems Approach to Hemostasis: How the Feedback Between Thrombus Structure and Molecular Transport Regulates the Hemostatic Response
... particularly in the core region where they are most tightly packed, provide a microenvironment where soluble species are protected from washout. Further, differences in physical factors between the core and shell regions ...
204
Suppression of hemostatic system activation by oral anticoagulants in the blood of patients with thrombotic diatheses
... We have previously observed that substantial elevations in Factor Xa activity but not thrombin activity regularly occur in the blood of many individuals with hereditary deficiencies of a[r] ...
11
Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus
... both thrombin cleavage and matrix metalloproteinase (MMP) cleavage induce enhanced adhesion compared with the effects of full-length ...increased activity of the RGD site, perhaps an indication of ...
8
b10b340a5d3425faa60622621a60730ddb02.pdf
... of thrombin generation in response to a pro- coagulant signal using platelet-rich or platelet-poor ...of thrombin activity is assessed as the amount of a chromogenic or fluorogenic substrate that is ...
8
The role of thrombin in gliomas
... In this study, argatroban reduced neurologic deficits in the glioma model. Traditional preclinical investigations of brain tumor therapies have focused primarily on inhibiting tumor cell proliferation or survival with ...
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CONGENITAL SPCA DEFICIENCY: A HITHERTO UNRECOGNIZED COAGULATION DEFECT WITH HEMORRHAGE RECTIFIED BY SERUM AND SERUM FRACTIONS
... It was conceivable that the faster thrombin evolution in the normal-pathological mixtures miay have been due to the additive effect of the small yet significant prothrombic activity of t[r] ...
14
Natural anticoagulant mechanisms
... Antithrombin neutralizes the activity of thrombin as well as other serine proteases of the intrinsic coagulation cascade by formation of a 1:1 stoichiometric complex between enzyme and i[r] ...
7
Inositol 1,4,5 triphosphate induced granule secretion in platelets Evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein dependent mechanism distinct from that of thrombin
... by thrombin is thought to be regulated by a pertussis toxin-sensitive guanine nucleotide binding protein (G protein) referred to as ...Unlike thrombin, however, U46619-induced phosphoinositide hydrolysis ...
8
Urokinase has direct catalytic activity against fibrinogen and renders it less clottable by thrombin
... antibody against thrombin, aprotinin, or alpha 2-antiplasmin. FPB release reflects a direct action of urokinase on fibrinogen because release is completely inhibited by a monospecific antibody against the enzyme. ...
11
Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats
... After instillation of S. pneumoniae, typical clinical symptoms of illness (pilo-erection, decreased activity, arched back, decreased food and water intake, and increased respiratory rate) did not occur until about ...
10
The Down syndrome critical region gene 1 short variant promoters direct vascular bed–specific gene expression during inflammation in mice
... moter activity in tumor endothelium, B16 melanoma cells were implanted subcutaneously in mice in the presence of adenovirus expressing either miGATA2 or miControl (Ad-miGATA2 or Figure ...
15
Importance of individual activated protein C cleavage site regions in coagulation Factor V for Factor Va inactivation and for Factor Xa activation
... FVa activity), fresh nFV (432 pm) was added to one aliquot of each incubation mixture (t = 0 on the ...FVa activity as described, at 40 pm final FXa. FVa activity in the samples without fresh nFV ...
12
Thrombin induction of plasminogen activator inhibitor in cultured human endothelial cells
... with thrombin for 24 h caused a sixfold increase in PA-I ...of thrombin was half-maximal at approximately ...PA-I activity required active alpha-thrombin and was not obtained with ...
6
ANISERP: a new serpin from the parasite Anisakis simplex
... Background: Serine proteinase inhibitors (serpins) finely regulate serine proteinase activity via a suicide substrate-like inhibitory mechanism. In parasitic nematodes, some serpins interact with host ...
10