Thrombin-antithrombin
Acceleration of thrombin antithrombin complex formation in rat hindquarters via heparinlike molecules bound to the endothelium
... of antithrombin at a site critical for heparin-dependent acceleration of the protease inhibitor resulted in a level of interaction product identical to the uncatalyzed ...of thrombin-antithrombin ...
11
Analysis of blood coagulation in mice: pre-analytical conditions and evaluation of a home-made assay for thrombin-antithrombin complexes
... Since the identification of genes encoding mouse clotting proteins and the creation of a growing number of trans- genic mice, the use of mouse models for the study of thrombotic disorders has gained increasing interest ...
10
Coagulation Changes in Children with Sickle Cell Anaemia during Painful Crises and Steady State at Federal Medical Centre Abeokuta, Nigeria
... Chinawa et al. [19] evaluated clotting profiles in paediatric SCA subjects and demonstrated significantly prolonged PT and PTTK values during steady state and painful crises. This finding however suggests a ...
17
Abnormal antithrombin III with defective serine protease binding (antithrombin III "Denver")
... progressive thrombin neutralization and anti-Xa activity. When thrombin-antithrombin (TAT) complexes were formed by incubating with excess thrombin, SDS-polyacrylamide gel electrophoresis ...
8
Global assays of hemostasis in the diagnostics of hypercoagulation and evaluation of thrombosis risk
... shorten APTT. APTT shortening has also been associ- ated with high levels of biochemical markers of thrombin generation and fibrin deposition such as prothrombin fragment 12, thrombin-antithrombin ...
15
Decreased antithrombin activity in the early phase of trauma is strongly associated with extravascular leakage, but not with antithrombin consumption: a prospective observational study
... intravascular thrombin formation through its ability to bind and inactivate thrombin by forming a thrombin-antithrombin complex ...sistent thrombin generation which could be a potential ...
10
Local hemostasis, immunothrombosis, and systemic disseminated intravascular coagulation in trauma and traumatic shock
... the thrombin- thrombomodulin complex and stimulates tissue factor expression on ...plasma thrombin generation ...the thrombin antithrombin complex (TAT) associated with IL-6 elevation ...
11
Lactobacillus casei modulates the inflammation-coagulation interaction in a pneumococcal pneumonia experimental model
... of thrombin-antithrombin complex (TATc) in bronchoalveolar lavage (BAL) and plasma, decrease in prothrombin activity (PT) and prolonged activated partial thromboplastin time test (APTT) ...
10
Effect of a 3-Week Low-Calorie Diet and Balneological Treatment on Selected Coagulation Parameters in Morbidly Obese Patients
... and thrombin. In the present study, in obese subjects the antithrombin activity was similar as compared to healthy ...and antithrombin activity [22]. Antithrombin, by binding thrombin, ...
7
Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats
... (a) thrombin-antithrombin com- plexes (TATc), (b) antithrombin activity (AT), (c) fibrin degradation products (FDP), (d) plasminogen activator activity (PAA%), and (e) plasminogen activator ...
10
The measurement of thrombin in clotting blood by radioimmunoassay
... human thrombin using rabbit anti-human thrombin ...ng thrombin/ml plasma, 500-fold more sensitive than clotting ...than thrombin by at least four orders of magnitude, and there is no ...
11
Defining the Role of Blood-Spinal Cord Barrier Breakdown and Spinal Thrombin Signaling tn the Development of Pain Following Neural Trauma
... spinal thrombin activity after a painful compression (Figure ...spinal thrombin with hirudin prevents astrocyte activation at day 7 (Figure ...rat thrombin also increases spinal GFAP expression at ...
455
Thrombin use in surgery: an evidence-based review of its clinical use
... of thrombin as a surgical hemostat. The initial thrombin was bovine in origin, but its use has been complicated by the formation of antibodies that cross-react with human coagulation ...Human ...
8
A coagulation pathway on bovine aortic segments leading to generation of Factor Xa and thrombin
... with antithrombin III originally present on the aortic segment ...pmol antithrombin III/10(6) cells). The Factor Xa-antithrombin III complex was observed by sodium dodecyl sulfate- polyacrylamide gel ...
13
The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective?
... main thrombin inhibitor in the brain (Guenther et ...of thrombin and promote stellation of astrocytes (Cavanaugh et ...inhibit thrombin (Mutch et al. 2001). PAI-1 may also inhibit thrombin ...
7
Engineering of serpins for vascular application
... Therapeutically, thrombin attenuation can be accomplished in three ways: by reducing the amount of active thrombin generated in the system, by directly inhibiting thrombin’s proteolytic activity, or by ...
195
Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen VI (187 Asn >Asp)
... As shown with the control samples, antithrombin forms a cathodal but active component on prolonged incubation, but with antithrombin Rouen-VI this is followed rapidly by formation of the[r] ...
11
Clinical review: Molecular mechanisms underlying the role of antithrombin in sepsis
... hand, antithrombin research conducted during the past two decades has attempted to establish the effectiveness and safety of antithrombin substitution in cases of severe sepsis in accordance with the ...
9
LIGHT SCATTERING STUDIES OF FIBRIN CLOTS
... Observations on Light Scattering of Plasma Clots The ionic strength, temperature, thrombin concentration by clotting with added thrombin and time of measurements after adding thrombin we[r] ...
8
Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor
... Diisopropylfluorophosphate-alpha-thrombin failed to stimulate mitogenesis except at concentrations having equivalent enzymatic activity as that of alpha-thrombin at its threshold for mitogenesis. Thus, ...
6