thrombospondin motifs
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family
... with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in ...
16
Exosomes from IL 1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes
... with thrombospondin motifs; CM: conditioned media; CM-exo: exosome-depleted conditioned media; Cont: control; DMEM: Dulbecco ’ s modified Eagle ’ s medium; EBM-2: endothelial basal medium-2; ECM: ...
11
Effects of a 15 month anti TNF α treatment on plasma levels of glycosaminoglycans in women with rheumatoid arthritis
... thrombospondin motifs; BMI: Body mass index; CRP: C-reactive protein; CS/ DS: Chondroitin/dermatan sulfate; DAS28: Disease Activity Score based on the evaluation of 28 joints; ECM: Extracellular matrix; ...
10
Biocompatibility and intradiscal application of a thermoreversible celecoxib loaded poly N isopropylacrylamide MgFe layered double hydroxide hydrogel in a canine model
... TIFF 15443 kb Abbreviations ACAN: aggrecan; ADAMTS5: a disintegrin and metalloproteinase with thrombospondin motifs 5; AF: annulus fibrosus; AIC: Akaike information criterion; BCL-2: B-c[r] ...
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Cytokine signaling 1 suppressor is inducible by IL 1beta and inhibits the catabolic effects of IL 1beta in chondrocytes: its implication in the paradoxical joint protective role of IL 1beta
... with thrombospondin motifs 4; CIS-1: Cytokine-inducible SH2-containing protein 1; DMEM: Dulbecco modified Eagle medium; ELISA: Enzyme-linked immunosorbent assay; ERK: Extracellular-signal-regulated kinase; ...
11
p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation
... TIFF 58 kb Abbreviations Ab: Antibody; ACAN: Aggrecan; ADAMTS: A disintegrin and metalloproteinase with thrombospondin motifs; CI: Confidence interval; COL2A1: Collagen, type II, alpha 1[r] ...
11
Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells – a rheumatoid arthritis mouse model
... with thrombospondin motifs; AIA: Antigen-induced arthritis; BSA: Bovine serum albumin; CEM: Complete expansion media; CIM: Cell isolation media; DMSO: Dimethyl sulphoxide; FACS: Fluorescence activated cell ...
14
Association between plasma ADAMTS-7 levels and ventricular remodeling in patients with acute myocardial infarction
... Members of the recently identified metalloproteinase family of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) also degrade ECM. However, the relevance of the ADAMTS family to ...
6
Developments in the scientific understanding of osteoarthritis
... ADAMTS = a disintegrin and metalloprotease with thrombospondin motifs; CCR = C-C chemokine receptor; COMP = cartilage oligomeric matrix protein; COX = cyclo-oxygenase; CTX-II = carboxyl-[r] ...
9
E2 regulates MMP 13 via targeting miR 140 in IL 1β induced extracellular matrix degradation in human chondrocytes
... miRNAs are a class of abundant, small, highly con- served noncoding RNA (approximately 22 nucleotides) found in higher eukaryotes. They act as multifunctional mediators of biological processes by partially base- pairing ...
10
Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells
... Differentiation of MSCs toward an NP phenotype is more complex than differentiation towards a hyaline chondrocyte lineage [21]. Differentiation toward an NP phenotype is likely to depend on diverse biological para- ...
13
Exosomes of stem cells from human exfoliated deciduous teeth as an anti-inflammatory agent in temporomandibular joint chondrocytes via miR-100-5p/mTOR
... ADAMTS5: Disintegrin and metalloproteinase with thrombospondin motifs 5; CM: Conditioned medium; Exos: Exosomes; GAPDH: Glyceraldehyde 3 phosphate dehydrogenase; IL-6: Interleukin-6; IL-[r] ...
12
Complementary action of granulocyte macrophage colony stimulating factor and interleukin 17A induces interleukin 23, receptor activator of nuclear factor κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis
... with thrombospondin motifs; ANOVA: Analysis of variance; CCL: CC chemokine ligand; CCR: CC chemokine receptor; CIA: Collagen-induced arthritis; CII: Type II collagen; Ct: Cycle threshold; CXCL: Chemokine ...
14
The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases
... Abstract: The a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) comprise a family of secreted zinc metalloproteinases with a precisely ordered modular organization. These enzymes play ...
11
Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis
... with thrombospondin motifs; aggrecanase-1) [29], and mono- clonal antibody (MAb) OA-1, specific for the N-terminal ARGS neoepitope generated by aggrecanase cleavage at the Glu-Ala bond within the aggrecan ...
10
Towards extracellular matrix normalization for improved treatment of solid tumors
... with thrombospondin motifs (ADAMTS), cathepsin, plasminogen activator, and b) GAG-degrading enzymes like hyaluronidase and heparanase (that cleave hyaluronic acid and heparan sulfate chains, respectively) ...
21
ADAMTS proteoglycanases in the physiological and pathological central nervous system
... with thrombospondin motifs’ family, composed of 19 ...a thrombospondin domain, a cysteine-rich domain, a spacer domain and finally a variable number of thrombospondin motifs in the ...
8
Deficiency of fibroblast activation protein alpha ameliorates cartilage destruction in inflammatory destructive arthritis
... with thrombospondin motifs; DMEM: Dulbecco ’ s modified Eagle ’ s medium; DPP4: dipeptidylpeptidase 4; ECM: extracellular matrix; FAP: fibroblast activation protein alpha; fap −/− : FAP knockout mouse; FCS: ...
7
Matrix assisted laser desorption ionization mass spectrometry imaging identifies markers of ageing and osteoarthritic cartilage
... Abbreviations ADAMTS: a distintegrin and metalloproteinase with thrombospondin motifs; COMP: cartilage oligomeric matrix protein; DA: discriminant anlysis; DDA: data dependant analysis; [r] ...
12
Isolation of the thrombospondin membrane receptor
... We have identified and isolated an 88-kd membrane glycoprotein present in platelets, endothelial cells, monocytes, and a variety of human tumor cell lines that is the membrane binding si[r] ...
9