thymidylate synthase (TYMS)
Thymidylate synthase gene (TYMS) polymorphisms in sporadic and hereditary breast cancer
... and TYMS (Thymidylate Synthase) [20] and, which are involved in events such as synthesis, methyla- tion and DNA damage repair, and cellular activation in carcinogen metabolism and the metabolism of ...
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The Role of Thymidylate Synthase in Pemetrexed Resistant Malignant Pleural Mesothelioma Cells
... only thymidylate synthase (TYMS) mRNA was overexpressed among other well-known molecular targets and chemosensitivity determinants of pemetrexed, and the role of the TYMS gene was ascertained ...
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Overexpression of thymidylate synthase (TYMS) is associated with aggressive tumor features and early PSA recurrence in prostate cancer
... Thymidylate synthase (TYMS) plays a role in DNA synthesis and is a target for ...study TYMS was analyzed by immunohistochemistry on a tissue microarray containing 11,152 prostate ...cancers. ...
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Association of thymidylate synthase expression and clinical outcomes of gastric cancer patients treated with fluoropyrimidine-based chemotherapy: a meta-analysis
... The search was conducted by consulting the online database PubMed, Embase, Web of Science, and Cochrane Library for all relevant papers published before June 30, 2015. The search strategy was performed using the ...
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Thymidylate synthase polymorphisms in genomic DNA as clinical outcome predictors in a European population of advanced non small cell lung cancer patients receiving pemetrexed
... whether thymidylate synthase (TS) genotype has an independent prognostic/predictive impact on a European population of advanced non-small cell lung cancer (NSCLC) patients receiving ...
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Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients
... as thymidylate synthase (TS), orotate phosphoribosyltrans- ferase (OPRT), and thymidine phosphorylase (TP) have already been investigated for their prognostic potentials in different ...
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Trichinella pseudospiralis vs T spiralis thymidylate synthase gene structure and T pseudospiralis thymidylate synthase retrogene sequence
... elegans) thymidylate synthase genes contain an additional conserved intron, corresponding to Trichinella intron ...carota thymidylate synthase, parts of the bifunctional genes, are found in ...
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Original Article Correlations between expression levels of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase, and efficacy of 5-fluorouracil-based chemotherapy for advanced colorectal cancer
... enzymes, thymidylate synthase (TS), thymidine phosphorylase (TP), and dihydropyrimidine de- hydrogenase (DPD) are known to play important roles in the efficacy of therapeutic ...
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Clinical significance of the thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase mRNA expressions in hepatocellular carcinoma patients receiving 5-fluorouracil-based transarterial chemoembolization treatment
... Purpose: To determine whether 5-fluorouracil (5-FU) sensitivity is associated with the mRNA expressions of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and[r] ...
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Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase
... (thymidylate synthase inhibitor) were compared with novel members of these two drug families in the treatment of a chemoresistant pancreatic cancer cell line ...
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Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase thymidylate synthase
... reductase-thymidylate synthase (pfDHFR-TS) is a well-defined target of antifolate drugs such as pyrimethamine and ...as thymidylate (dTMP) required for DNA synthesis ...
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<p>Proteomics of Sentinel Lymph Nodes in Early Breast Cancer for Identification of Thymidylate Synthase as a Potential Biomarker to Flag Metastasis: A Preliminary Study</p>
... anti-thymidylate synthase antibody (Elabsciences; 1:10,000) and anti- β -actin antibody (Elabsciences; 1:10,000), at 4 °C ...the thymidylate synthase and β -actin bands intensity in blot ...
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Prevalence of thymidylate synthase gene 5'-untranslated region variants in an Argentinean sample.
... the TYMS 5'-UTR polymorphism (rs45445694 in the reference sequence GenBank accession ...the TYMS 5'-UTR region (forward, 5'-AGGCGCGCGGAAGGGGTCCT-3'; and reverse, 5'-TCCGAGCCGGCCACAGGCAT-3'; IDT, Coralville, ...
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A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations
... that TYMS and MTHFR compete for the available supply of ...of TYMS may differentially impact the levels of 5,10- methyleneTHF available to MTHFR, thereby indirectly affecting both 5-methylTHF and plasma ...
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siRNA Targeting of Thymidylate Synthase, Thymidine Kinase 1 and Thymidine Kinase 2 as an Anticancer Therapy: A Combinatorial RNAi Approach
... only in combination with higher 5FUdR concentrations that reduce TS activity and cell viability more profoundly. These possibilities are appropriate for future investigation. Issues such as those discussed above might be ...
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Thymidylate synthase gene of herpesvirus ateles.
... A single viral genome region was found to be transcribed in tumor-derived, herpesvirus saimiri-transformed lymphoid cells 28; computer screening of nucleotide sequence 3 and of protein d[r] ...
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Polymorphisms of MTHFR and TYMS predict capecitabine-induced hand-foot syndrome in patients with metastatic breast cancer
... 5-fluorouracil; TYMS: thymidylate synthase; MTHFR: methylene tetrahydrofolate reductase; RRM1: ribonucleotide reductase M1; dUMP: deoxyuridine monophosphate; dTMP: deoxythymidine monophosphate; 5-10 ...
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Organization of the thymidylate synthase gene of herpesvirus saimiri.
... pseudorabies virus 69% 19, and human cytomegalovirus 56% 13, did not induce TS activity in permissive cells during virus replication 22, and no nucleotide or amino acid sequence homology[r] ...
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trans activation of the thymidylate synthase promoter of herpesvirus saimiri.
... Here we describe the regulation of the herpesvirus saimiri TS gene that is increasingly expressed from delayed-early to late times of virus infection and identify a genomic upstream regi[r] ...
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Analysis of T4 bacteriophage deletion mutants that lack td and frd genes.
... If thymidylate synthase and dihydrofolate reductase are the baseplate components that serve as antigenic determinants of phage particles, antibodies against the cloned gene products shou[r] ...
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