Thyroid Hormone
An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell specific over expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary selective resistance to thyroid hormone
... presentation tends to segregate within the kindred, there is no absolute concordance, and even among siblings the phenotype differences can be remarkable [14]. In vitro experiments demonstrated that the R338W mutant ...
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Thyroid hormone status in children with protein energy malnutrition a hospital based case control study
... thyroid hormone status in these ...and thyroid stimulating hormone (TSH) levels in PEM and healthy ...onthyroid hormone status and to see the correlation between thyroid hormones ...
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Mechanisms of thyroid hormone action
... of thyroid hormone signaling and mutant TRs in several forms of ...of thyroid cancer ...and thyroid cancer (127, ...of thyroid cancer ...tivates thyroid hormone, has been ...
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Antagonism of thyroid hormone action by amiodarone in rat pituitary tumor cells
... to thyroid hormone action as defined by its dose-dependent ability to (a) bind to the thyroid hormone receptor and (b) inhibit T3-induced increases in growth hormone mRNA levels in a ...
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A base mutation of the C erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance Molecular heterogeneity in two other kindreds
... Generalized thyroid hormone resistance (GTHR) is a disorder of thyroid hormone action that we have previously shown to be tightly linked to one of the two thyroid hormone ...
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Screening of nineteen unrelated families with generalized resistance to thyroid hormone for known point mutations in the thyroid hormone receptor beta gene and the detection of a new mutation
... to thyroid hormone (GRTH) is a syndrome characterized by impaired tissue responsiveness to thyroid ...the hormone binding domain of the thyroid hormone receptor (TR) beta have ...
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Differential expression of mutant and normal beta T3 receptor alleles in kindreds with generalized resistance to thyroid hormone
... Thyroid hormone resistance (THR) is primarily an autosomal dominant inherited disease characterized by resistance of pituitary and peripheral tissues to the action of thyroid ...to thyroid ...
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Nuclear thyroid hormone receptors
... Isolation ofa cDNA encoding human Rev-ErbAa: transcription from the non-coding DNA strand of a thyroid hormone receptor gene results in a related protein which does not bind thyroid horm[r] ...
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Thyroid hormone action in the absence of thyroid hormone receptor DNA binding in vivo
... compared thyroid hormone regulation of S- and M-cone opsin enhancer ele- ments, supports this conclusion ...however, thyroid hormone treatment stimulated gene expression via this ...element. ...
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Coexistence of resistance to thyroid hormone and papillary thyroid carcinoma
... In general, TSH suppression therapy is considered useful to prevent recurrence of thyroid carcinoma. However, there is no agreed consensus regarding the management of DTC in patients with RTH. Unluturk et al. (10) ...
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Thyroid hormone and anti-apoptosis in tumor cells
... by thyroid hormone of expression of the BCL2 family of genes [58, 59] also has anti-apoptotic ...membrane. Thyroid hormone activates expression of MCL1 [59], preventing mitochondrial membrane ...
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Original Article Expression of thyroid hormone responsive spot 14 homolog and thyroid hormone receptor β1 in human breast cancer tissues and its clinical significance
... Thrsp protein expression and TRβ1 protein expression was also investigated. Results: The positive expression rate of Thrsp in breast cancer tissues was higher than that in tumor-adjacent tissues, but the positive ...
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Thyroid hormone–sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform–specific
... for thyroid hormone. We used the thyroid hor- mone receptor-β–selective (TR-β–selective) ligand, GC-1, to determine by a pharmacological approach whether adaptive thermogenesis was TR ...distinct ...
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Thyroid stimulating hormone, independent of thyroid hormone, can elevate the serum total cholesterol level in patients with coronary heart disease: a cross-sectional design
... the thyroid hormones should be considered as important confounding factors when considering the relationship between TSH and lipid ...the thyroid hormone ...the thyroid hormones in the present ...
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Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine guanine rich areas of the thyroid hormone receptor beta gene Analysis of 15 families
... to thyroid hormone (GRTH) is a syndrome of variable reduction of tissue responsiveness to thyroid ...human thyroid hormone receptor beta (TR beta) gene have been associated with ...of ...
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Associations of thyroid hormone serum levels with in-vivo Alzheimer’s disease pathologies
... Preclinical studies have found a negative association between brain T3 and APP expression using a transgenic mouse model of AD [8, 9, 30], and a human autopsy study [10] revealed decreases in cerebral T3 levels in ...
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Thyroid hormone resistance syndrome Inhibition of normal receptor function by mutant thyroid hormone receptors
... Thyroid hormone (T3) resistance is inherited in most cases in an autosomal dominant ...free thyroid hormone levels and partial resistance to thyroid hormone at the cellular ...
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Resistance to thyroid hormone β in autoimmune thyroid disease: a case report and review of literature
... ternal thyroid hormone levels gradually decreases in preg- nancy, thus making the fetal growth environment reasonably less ...in thyroid hormone levels during pregnancy is common, and should ...
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← Return to Article Details Extra-Thyroidal Factors Impacting Thyroid Hormone Homeostasis
... maintaining thyroid hormone expression in local tissues. The thyroid secretes thyroxine (T4) at substantially greater levels than triiodothyronine (T3), relying on peripheral mechanisms to convert T4 ...
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microRNA and thyroid hormone signaling in cardiac and skeletal muscle
... Thyroid hormone (TH) signaling plays critical roles in the differentiation, growth, metabolism, and physiological func‑ tion of all organs or tissues, including heart and skeletal ...
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