Thyroid-Hormone Receptor
A base mutation of the C erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance Molecular heterogeneity in two other kindreds
... Generalized thyroid hormone resistance (GTHR) is a disorder of thyroid hormone action that we have previously shown to be tightly linked to one of the two thyroid hormone ...
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Molecular characterization of thyroid hormone receptor beta from Schistosoma japonicum and assessment of its potential as a vaccine candidate antigen against schistosomiasis in BALB/c mice
... japonicum thyroid hormone receptor The total RNAs were extracted from 21d worms using Trizol reagent (Invitrogen), following the manufacturer’s ...tive thyroid hormone ...
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New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone
... to thyroid hormone (GRTH) is a syndrome of hyposensitivity to triiodothyronine (T3) that displays autosomal dominant ...major thyroid hormone receptor (TR) isoforms, TR alpha and TR ...
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Oncogenic mutations of thyroid hormone receptor β
... The C-terminal frame-shift mutant of the thyroid hormone receptor TRβ1, PV, functions as an oncogene. An important question is whether the oncogenic activity of mutated TRβ1 is uniquely dependent on ...
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An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell specific over expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary selective resistance to thyroid hormone
... Background: The syndrome of resistance to thyroid hormone (RTH) is caused by mutations in the thyroid hormone receptor b gene ( THRB ). The syndrome varies from asymptomatic to diffuse ...
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Screening of nineteen unrelated families with generalized resistance to thyroid hormone for known point mutations in the thyroid hormone receptor beta gene and the detection of a new mutation
... to thyroid hormone (GRTH) is a syndrome characterized by impaired tissue responsiveness to thyroid ...the hormone binding domain of the thyroid hormone receptor (TR) beta ...
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Original Article Expression of thyroid hormone responsive spot 14 homolog and thyroid hormone receptor β1 in human breast cancer tissues and its clinical significance
... of thyroid hormone responsive spot 14 homolog (Thrsp) and thyroid hormone receptor β1 (TRβ1) proteins in human breast cancer tissues and adjacent tissues, as well as its relationship ...
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Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine guanine rich areas of the thyroid hormone receptor beta gene Analysis of 15 families
... to thyroid hormone (GRTH) is a syndrome of variable reduction of tissue responsiveness to thyroid ...human thyroid hormone receptor beta (TR beta) gene have been associated with ...
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Critical role for thyroid hormone receptor β2 in the regulation of paraventricular thyrotropin releasing hormone neurons
... ligand-independent activation of TRH gene expression is completely absent in TR- β 2–null mice. This observa- tion further supports our conclusion that TR-β2 is the critical regulator of thyroid hormone ...
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Thyroid hormone–sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform–specific
... for thyroid hormone. We used the thyroid hor- mone receptor-β–selective (TR-β–selective) ligand, GC-1, to determine by a pharmacological approach whether adaptive thermogenesis was TR ...
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DESIGNING NATURAL AGONISTS FOR THYROID HORMONE RECEPTOR ALFA 1
... CONCLUSION: Hypothyroidism is the commonest clinical disorder of thyroid function. At present there is no natural potent drug available to treat hypothyroidism. Molecular docking is one of the powerful techniques ...
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6 OXA 3 THIAOCTANOIC ACID HAS POTENTIAL INHIBITORS AGAINST THYROID CANCER IN SILICO ANALYSIS
... for thyroid cancer, here we used GC-MS analyzed compound identified from ...inhibiting thyroid hormone receptor alpha1 (TRα1) responsible to thyroid ...
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Thyroid hormone resistance syndrome Inhibition of normal receptor function by mutant thyroid hormone receptors
... Thyroid hormone (T3) resistance is inherited in most cases in an autosomal dominant ...free thyroid hormone levels and partial resistance to thyroid hormone at the cellular ...
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Antagonism of thyroid hormone action by amiodarone in rat pituitary tumor cells
... to thyroid hormone action as defined by its dose-dependent ability to (a) bind to the thyroid hormone receptor and (b) inhibit T3-induced increases in growth hormone mRNA levels ...
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Thyroid hormone action in the absence of thyroid hormone receptor DNA binding in vivo
... are similar to those observed in TR- β 2 KO mice, indi- cating that the DNA-binding function of TR-β was essential for cone opsin gene expression in the retina. Like the retina, thyroid hormone is also ...
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Asialoagalacto human chorionic gonadotropin, a carbohydrate modified variant of human chorionic gonadotropin, antagonizes the stimulatory actions of bovine thyroid stimulating hormone on thyroid function and HLA DR expression in human thyroid in vitro and in vivo
... using thyroid-stimulating hormone (TSH) receptor antagonists in the management of Graves' disease is ...TSH receptor antagonist derived from human chorionic gonadotropin (hCG) with respect to ...
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Case Report Malignant transformation of benign thyroid nodule is caused by prolonged H
... benign thyroid cyst and PTC tissue, we found that the “acute phase response signal- ling” was activated in the benign ...signal receptor and transmitter in transcription factor redox regulation ...
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Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans
... glucocorticoid receptor (hGR) pre-mRNA generates two highly homologous isoforms, termed hGR alpha and hGR ...the hormone-bound state, modulates the expression of glucocorticoid-responsive genes by binding ...
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Clinical Profile of Hyperthyroidism at Stanley Hospital
... of thyroid overactivity such as Graves' disease and toxic multinodular goiter; in subacute or chronic thyroiditis, where it is released as a consequence of tissue damage; and in patients with large goiters, in ...
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Thyroid hormone T3 acting through the thyroid hormone α receptor is necessary for implementation of erythropoiesis in the neonatal spleen environment in the mouse
... the thyroid gland and coordinate a multitude of physiological responses and developmental processes in all vertebrates (Yen, ...nuclear hormone receptors family, the thyroid hormone receptors ...
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