thyroid hormone receptor
Oncogenic mutations of thyroid hormone receptor β
... ABSTRACT The C-terminal frame-shift mutant of the thyroid hormone receptor TRβ1, PV, functions as an oncogene. An important question is whether the oncogenic activity of mutated TRβ1 is uniquely ...
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Targeting of Thyroid Hormone Receptor Variants to Aggresomes
... the thyroid hormone receptor (TR), is an example of a mutant protein that has altered subcellular localization and interferes with its wild type derivative ...
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An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell specific over expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary selective resistance to thyroid hormone
... Anna Teresa Alberobello 1 , Valentina Congedo 1,2 , Hong Liu 3 , Craig Cochran 1 , Monica C Skarulis 1 , Douglas Forrest 3 and Francesco S Celi 1* Abstract Background: The syndrome of resistance to thyroid ...
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New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone
... to thyroid hormone (GRTH) is a syndrome of hyposensitivity to triiodothyronine (T3) that displays autosomal dominant ...major thyroid hormone receptor (TR) isoforms, TR alpha and TR ...
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DESIGNING NATURAL AGONISTS FOR THYROID HORMONE RECEPTOR ALFA 1
... the thyroid gland does not produce enough thyroid ...the thyroid gland, which damages the gland’s ...this hormone. Thyroid hormone receptor alfa-1 (THRA1) is an endocrine ...
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Characterizing Importin Binding to Thyroid Hormone Receptor α1 1
... Abstract Thyroid hormone, or T 3 , is essential in many bodily functions, from early development to the maintenance of health in ...The thyroid hormone receptor, TR, is a major mediator ...
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Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone Identification of thirteen novel mutations in the thyroid hormone receptor beta gene
... the thyroid hormone receptor beta gene, except for a single case of a seven nucleotide ...the hormone- binding domain of the ...Mutant receptor binding to ligand was moderately or ...
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A base mutation of the C erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance Molecular heterogeneity in two other kindreds
... Generalized thyroid hormone resistance (GTHR) is a disorder of thyroid hormone action that we have previously shown to be tightly linked to one of the two thyroid hormone receptor genes,[r] ...
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Multiple Novel Signals Mediate Thyroid Hormone Receptor Nuclear Import and Export
... of thyroid hormone receptor  1 may be a contributing fac- tor in resistance to thyroid hormone ...nuclear receptor function in ...
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The nuclear corepressor 1 and the thyroid hormone receptor suppress breast tumor lymphangiogenesis
... Vascular Endotelial Growth Factors C and D (VEGF-C and VEGF-D) are crucial regulators of lymphangiogenesis, a main event in the metastatic spread of breast cancer tumors. Although inhibition of lymphangiogenic gene ...
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Development and validation of in vitro bioassays for thyroid hormone receptor mediated endocrine disruption
... for thyroid hormone receptor agonists and ...to thyroid hormones, nor reported to be thyroid hormone receptor disruptors, so false negatives were not ...resemble ...
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Constant velocity pulling and unfolding of thyroid hormone receptor by steered molecular dynamics
... liganded thyroid hormone receptor (THRT3) can be studied by using the protocols of steered molecular dynamics ...a receptor protein’s LBD towards hormone activated gene expressions ...
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Molecular dynamics approach to the I431V mutational impact on thyroid hormone receptor-beta
... on thyroid hormone receptor-beta (THR-β) gene cause resistance to thyroid hormones (RTH) with the clinical diagnosis of elevated free triiodothyronine (T3) and free thyroxin (T4) but not ...
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Screening of nineteen unrelated families with generalized resistance to thyroid hormone for known point mutations in the thyroid hormone receptor beta gene and the detection of a new mutation
... to thyroid hormone (GRTH) is a syndrome characterized by impaired tissue responsiveness to thyroid ...the hormone binding domain of the thyroid hormone receptor (TR) beta ...
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Original Article Expression of thyroid hormone responsive spot 14 homolog and thyroid hormone receptor β1 in human breast cancer tissues and its clinical significance
... of thyroid hormone responsive spot 14 homolog (Thrsp) and thyroid hormone receptor β1 (TRβ1) proteins in human breast cancer tissues and adjacent tissues, as well as its relationship ...
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Cloning and expression of a thyroid hormone receptor alpha 1 in the perennibranchiate amphibian Proteus anguinus
... Int J Dt"'" BioI ~II 537 5 0 (llJ961 537 Original Arfir/I' Cloning and expression of a thyroid hormone receptor ex1 in the perennibranchiate amphibian Proteus anguinus THUY D HO HUYNH', CLAUDE L GALLI[.] ...
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Thyroid hormone action in the absence of thyroid hormone receptor DNA binding in vivo
... To investigate further the molecular mechanism of abnormal regulation of the H-P-T axis in TR- β GS/GS mice, mice were examined in both a thyroid hor- mone-deficient and an excess state. After 5 weeks of a Lo I/ ...
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Thyroid hormone–sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform–specific
... distinct thyroid-dependent pathways, stimulation of UCP1 and augmentation of adrenergic responsiveness, are mediated by different TR isoforms in the same ...
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Arsenic as an Endocrine Disruptor: Arsenic Disrupts Retinoic Acid Receptor–and Thyroid Hormone Receptor–Mediated Gene Regulation and Thyroid Hormone–Mediated Amphibian Tail Metamorphosis
... on hormone signaling at key developmental or differentiation points might be expected to result in long-term effects related to epi- genetic phenomena such as ...
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Critical role for thyroid hormone receptor β2 in the regulation of paraventricular thyrotropin releasing hormone neurons
... Fasting leads to reduced activity of the HPT axis (25). The basis for this is decreased expression and synthesis of TRH (20). Recent data have revealed that a fall in lep- tin plays a central role in this phenomenon (20, ...
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