Thyroid Hormone Receptor Gene
Nuclear thyroid hormone receptors
... Isolation ofa cDNA encoding human Rev-ErbAa: transcription from the non-coding DNA strand of a thyroid hormone receptor gene results in a related protein which does not bind thyroid horm[r] ...
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An arginine to histidine mutation in codon 311 of the C erbA beta gene results in a mutant thyroid hormone receptor that does not mediate a dominant negative phenotype
... beta thyroid hormone receptor gene in a kindred, ...to thyroid hormones ...thyrotropin-stimulating hormone, markedly elevated serum free thyroxine (T4) and total triiodothyronine ...
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An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell specific over expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary selective resistance to thyroid hormone
... mutant receptor has reduced affinity for TH and a dominant negative activity typical of RTH syndrome ...of thyroid hormone in the thyrotroph is the inhibition of TSH b-subunit gene ...
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Direct modulation of simian virus 40 late gene expression by thyroid hormone and its receptor.
... These receptor-GTF protein-protein interactions might preclude these basal transcription factors from properly associating with other general transcription fac- ...unliganded thyroid receptors by both ...
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Molecular characterization of thyroid hormone receptor beta from Schistosoma japonicum and assessment of its potential as a vaccine candidate antigen against schistosomiasis in BALB/c mice
... housekeeping gene for this study ...ductase gene were 5 0 -CGAGGACCTAACAGCAGAGG- 3 0 (sense) and 5 0 -TCCGAACGAACT TTGAATCC-3 0 (antisense), and the PCR product size of the internal con- trol is 174 ...
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Mutations of CpG dinucleotides located in the triiodothyronine (T3) binding domain of the thyroid hormone receptor (TR) beta gene that appears to be devoid of natural mutations may not be detected because they are unlikely to produce the clinical phenotype of resistance to thyroid hormone
... the thyroid hormone receptor (TR) beta gene that appears to be devoid of natural mutations may not be detected because they are unlikely to produce the clinical phenotype of resistance to ...
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Original Article Expression of thyroid hormone responsive spot 14 homolog and thyroid hormone receptor β1 in human breast cancer tissues and its clinical significance
... synthase gene transcription [24, ...THRSP gene. CCND1 gene is a downstream candidate cancer gene, and its overexpression is involved in the occurrence and development of breast cancer ...CCND1 ...
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Thyroid hormone action in the absence of thyroid hormone receptor DNA binding in vivo
... are similar to those observed in TR- β 2 KO mice, indi- cating that the DNA-binding function of TR-β was essential for cone opsin gene expression in the retina. Like the retina, thyroid hormone is ...
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Early-age feed restriction affects viability and gene expression of satellite cells isolated from the gastrocnemius muscle of broiler chicks
... Results: One-day-old broiler chicks were allocated to control (Con, ad libitum feeding), intermittent feeding (IF, feed provided on alternate days) and re-feeding (RF, 2 days ad libitum feeding after 12 days of ...
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Novel SNPs of the porcine TRIP12 are associated with water holding capacity of meat
... The thyroid hormone receptor interacting protein 12 (TRIP12) is known as a HECT domain-containing E3 ubiquitin-protein ligase that recognizes protein substrates for ...TRIP12 gene and to ...
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Thyroid hormone receptor and albumin gene expression in Xenopus laevis ovary and liver
... (hepatocyte nuclear factor 1). In further experiments (Baumhueter et a l , 1988) it was shown that a de differentiated variant of the hepatoma cell line Fao had lost HNF-1 but gained a related protein, vHNF-1 (v for ...
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Mechanisms of thyroid hormone action
... of gene repression by transcription factor corepressors in development and homeostasis is being increas- ingly recognized (71, ...unliganded receptor had a repressive effect on genes positively regulated by ...
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Oncogenic mutations of thyroid hormone receptor β
... human thyroid cancer cells [17] and breast cancer MCF cells ...estrogen receptor, the tumor suppressor effect of TRβ1 is estradiol-dependent ...Thrb gene to gain advantages in cell proliferation, ...
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Thyroid hormone and anti-apoptosis in tumor cells
... the thyroid gland, L-thyroxine (T 4 ), is anti-apoptotic at physiological concentrations in a number of cancer cell ...the hormone are interference with the Ser-15 phosphorylation (activation) of p53 and ...
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A clinician’s guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoforms
... different conformation in the unliganded state. The co-repressor complex alters its surrounding chromatin structure by removing acetyl groups from histones to induce a conformational change in the histone struc- ture ...
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Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone Identification of thirteen novel mutations in the thyroid hormone receptor beta gene
... the thyroid hormone receptor beta gene, except for a single case of a seven nucleotide ...the hormone- binding domain of the ...Mutant receptor binding to ligand was moderately ...
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Resistance to thyroid hormone β in autoimmune thyroid disease: a case report and review of literature
... goiter. Thyroid function tests showed FT4 at ...releasing hormone (TRH); liothyronine (L-T3) suppressed TSH from ...abnormality. Gene se- quencing identified a heterozygous Y321C substitution mu- ...
5
Growth and Development in a Child With Resistance to Thyroid Hormone and Ectopic Thyroid Gland
... and thyroid dysgenesis would be expected to occur by chance in just 1:140 000 ...the thyroid hormone receptor may also have a role in thyroid organogene- ...sis. Thyroid ...
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Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine guanine rich areas of the thyroid hormone receptor beta gene Analysis of 15 families
... to thyroid hormone (GRTH) is a syndrome of variable reduction of tissue responsiveness to thyroid ...human thyroid hormone receptor beta (TR beta) gene have been ...
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Screening of nineteen unrelated families with generalized resistance to thyroid hormone for known point mutations in the thyroid hormone receptor beta gene and the detection of a new mutation
... respectively, only in affected members of each of the two index families. Primers containing the normal sequences amplified exons 7 and 8 of the TR beta gene in all subjects except affected members of one family. ...
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