Thyrotropin receptor
Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves’ disease
... human thyrotropin receptor ...recombinant receptor expressed at the surface of stably transfected Chinese hamster ovary (CHO) cells, and sera from most of the immunized mice blocked TSH-dependent ...
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The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim
... Graves disease, a common organ-specific autoimmune disease affecting humans, differs from all other autoimmune diseases in being associated with target organ hyperfunction rather than organ damage. Clinical ...
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Familial congenital hypothyroidism due to inactivating mutation of the thyrotropin receptor causing profound hypoplasia of the thyroid gland
... the thyrotropin re- ceptor gene, we identified the substitution of threonine in place of a highly conserved alanine at position 553, in the fourth predicted transmembrane ...wild-type receptor, in spite of ...
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Circulating thyrotropin receptor messenger ribonucleic acid is not an effective marker in the follow-up of differentiated thyroid carcinoma
... Circulating thyrotropin receptor messenger ribonucleic acid (TSHR mRNA) assay has been validated in the follow-up of differentiated thyroid carcinoma (DTC) because of its high sensitivity during thyroid ...
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Concentration dependent regulation of thyrotropin receptor function by thyroid stimulating antibody
... Graves disease is one of the more common human autoimmune diseases (1–3) and is caused by the development of thyrotropin receptor (TSHR) autoantibodies (TSHR-Ab’s) that bind to and stimulate the TSHR. The ...
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Thyrotropin receptor–associated diseases: from adenomata to Graves disease
... hormone receptor (TSHR) is a G protein–linked, 7–transmembrane domain (7-TMD) receptor that undergoes complex posttranslational processing unique to this glycoprotein receptor ...
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Molecular description of non-autoimmune hyperthyroidism at a neonate caused by a new thyrotropin receptor germline mutation
... this receptor can be modified selectively for specific signaling properties and this might have impact also on the patient`s thyroid function and thereby the patient`s ...
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Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281 >isoleucine) in the extracellular domain of the thyrotropin receptor
... TSH receptor cDNA in the expres- sion vector pSVL, and a pSVL-TSH receptor construct containing the activating mutation Phe631 → Leu were gifts from ...
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Accuracy of receptor-based methods for detection of thyrotropin-receptor autoantibodies: a new automated third-generation immunoassay shows higher analytical and clinical sensitivity for the differential diagnosis of hyperthyroidism
... The RAD 120 anti-TSHR fluorescent immunoassay uses a preformed immunocomplex based on native porcine TSHR solubilized from a thyroid cell membrane prepara- tion and anti-porcine TSHR mouse mAb coated on mag- netic ...
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Precipitation of the thyrotropin receptor and identification of thyroid autoantigens using Graves' disease immunoglobulins
... structurally characterized by immunological means. To this end, four sera from patients with hyperthyroidism, three of which inhibited the binding of 125I-TSH to Triton-solubilized human thyroid membranes, were used to ...
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Metabolic clearance and secretion rates of subunits of human thyrotropin
... Metabolic clearance rates (MCR) of the alpha and beta subunits of human thyrotropin (hTSH-alpha and hTSH-beta) were determined by a constant infusion to equilibrium method. In 15 normal individuals (six men, six ...
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Metabolism and Excretion of Exogenous Thyrotropin Releasing Hormone in Humans
... To study the metabolism of thyrotropin-releasing hormone (TRH) in vivo, 400 µg TRH was administered intravenously to eight normal male subjects. Multiple plasma and urine samples were obtained before and after TRH ...
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Thyrotropin Increases Prostaglandin Levels in Isolated Thyroid Cells
... both thyrotropin (TSH) and prostaglandins E (PGE 1 , PGE 2 ) stimulation of thyroidal adenyl cyclase activation and cyclic 3¢,5¢-adenosine monophosphate (cAMP) formation, suggesting that prostaglandins play an ...
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IMMUNOLOGIC AND BIOLOGIC CHARACTERIZATION OF ANTISERA TO BEEF THYROTROPIN PREPARATIONS
... Figure 7A shows that the anti-Condliffe TSH antiserum, after absorption with bovine serum, produces a single precipitin arc in the fast beta mobility range when reacted with its homologo[r] ...
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Effects of Thyrotropin-Releasing Hormone in Minimal Brain Dysfunction
... Evidence has been put forward of both under- arousal and overarousal of the central nervous system in children with minimal brain dysfunc- tion.6 The conflict may reflect heterogeneity o[r] ...
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Thyroid Hormone Inhibition of the Prolactin Response to Thyrotropin Releasing Hormone
... The influence of serum triiodothyronine (T 3 ) and thyroxine (T 4 ) concentrations on the release of prolactin in man was studied by determining the prolactin response to synthetic thyrotropin-releasing hormone ...
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First in class thyrotropin releasing hormone (TRH) based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models
... neurodegenerative animal models. Additionally, JAK4D brain permeation was examined in mouse, and initial toxicology was assessed in vivo and in vitro. We report that JAK4D bound selectively with nanomolar affinity to ...
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Antineutrophil autoantibodies in Graves' disease Implications of thyrotropin binding to neutrophils
... The hyperthyroidism of Graves' disease may be caused by autoantibodies to thyrotropin (TSH) receptors. We have found that patients with this disease have autoantibodies to neutrophils as well, which can be ...
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Variable Thyrotropin Response to Thyrotropin releasing Hormone after Small Decreases in Plasma Free Thyroid Hormone Concentrations in Patients with Nonthyroidal Diseases
... injected thyrotropin-releasing hormone (TRH) before and after effecting a small decrease in serum thyroxine (T 4 ) and/or T 3 concentrations by iodide treatment, 262 mg daily for 10 ...
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EARLY EFFECTS OF THYROTROPIN ON PROTEIN BOUND IODINE131 AND PLASMA IODIDE131
... Following 6 hours of equiliEffects of TSH on plasma iodidel3' and PBIP3' in bration the subsequent disappearance of the ioeuthyroid subjects dide'3' had increased to a T/2 of 7.0 hours w[r] ...
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